Acute influences of some ACTH-related peptides on fighting and adrenocortical activity in male laboratory mice

Brain, Paul F.; Evans, Angela E.

doi:10.1016/0091-3057(77)90210-6

Cited by 41 publications

(9 citation statements)

References 24 publications

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“…Thus, the impact of this pre-social encounter hormonal manipulation greatly differs from our published model in which prior stress forces the resulting hierarchy, with the stressed male turning into the subordinate status in both the immediate and the delayed tests (Cordero and Sandi, 2007). This might be surprising according to earlier studies in diverse species reporting a link between increased glucocorticoid levels and increased aggressiveness (Brain and Evans, 1977;Heller, 1978;Hayden-Hixson and Ferris, 1991a,b;Haller et al, 1997). However, a close examination of the literature reveals the existence of several studies in which increasing corticosterone levels was found to increase submissive behaviors Leshner et al, , 1980Moyer and Leshner, 1976;Leshner and Politch, 1979).…”

Section: Discussionmentioning

confidence: 89%

A role for glucocorticoids in the long-term establishment of a social hierarchy

Timmer¹,

Sandi²

2010

Psychoneuroendocrinology

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Stress can affect the establishment and maintenance of social hierarchies. In the present study, we investigated the role of increasing corticosterone levels before or just after a first social encounter between two rats of a dyad in the establishment and the long-term maintenance of a social hierarchy. We show that pre-social encounter corticosterone treatment does not affect the outcome of the hierarchy during a first encounter, but induces a long-term memory for the hierarchy when the corticosterone-injected rat becomes dominant during the encounter, but not when it becomes subordinate. Post-social encounter corticosterone leads to a long-term maintenance of the hierarchy only when the subordinate rat of the dyad is injected with corticosterone. This corticosterone effect mimics previously reported actions of stress on the same model and, hence, implicates glucocorticoids in the consolidation of the memory for a recently established hierarchy.

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Section: Discussionmentioning

confidence: 89%

A role for glucocorticoids in the long-term establishment of a social hierarchy

Timmer¹,

Sandi²

2010

Psychoneuroendocrinology

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“…ACTH, the anterior pituitary tropic hormone that regulates glucocorticoid release from the adrenal glands, is elevated in adrenalectomized animals, due to a lack of negative feedback, and levels of the hormone decrease when animals are treated with exogenous glucocorticoids. It has been suggested that these changes in ACTH and not downstream changes in cortisol or corticosterone are responsible for changes in aggression (Leshner et al, ; Moyer and Leshner, ; Brain and Evans, ). For example, exogenous ACTH administration decreased the aggressiveness of mice in which glucocorticoid levels had been experimentally controlled, suggesting that ACTH, rather than glucocorticoid levels are critical in the control of aggressiveness (Leshner et al, ).…”

Section: Discussionmentioning

confidence: 99%

Short‐day aggression is independent of changes in cortisol or glucocorticoid receptors in male Siberian hamsters (Phodopus sungorus)

et al. 2015

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Testosterone mediates aggression in many vertebrates. In some species, aggression remains high during the non-breeding season (e.g., winter), when testosterone levels are low. In Siberian hamsters (Phodopus sungorus), we have demonstrated photoperiodic changes in aggression with hamsters housed in short, "winter-like" days displaying significantly more territorial aggression than long-day animals, despite low levels of testosterone. The mechanisms by which photoperiod regulates aggression, however, remain largely unknown. Adrenocortical hormones (e.g., glucocorticoids) have been implicated in mediating seasonal aggression; circulating concentrations of these hormones have been correlated with aggression in some species. The goal of this study was to examine the role of cortisol and glucocorticoid receptors in mediating photoperiodic changes in aggression in male Siberian hamsters. Males were housed in long or short days and treated with either exogenous cortisol or vehicle. Circulating levels of cortisol, adrenal cortisol content, and aggression were quantified. Lastly, photoperiodic effects on glucocorticoid receptor (GR) protein levels were quantified in limbic brain regions associated with aggression, including medial prefrontal cortex, amygdala, and hippocampus. Short-day hamsters were more aggressive than long-day hamsters, however cortisol treatment did not affect aggression. Photoperiod had no effect on serum or adrenal cortisol or GR levels in the brain regions examined. Taken together, these data suggest that increases in cortisol levels do not cause increases associated with short-day aggression, and further that GR protein levels are not associated with photoperiodic changes in aggression. The results of this study contribute to our understanding of the role of adrenocortical steroids in mediating seasonal aggression.

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“…ACTH binds to the melanocortin type 2 G protein-coupled receptor (MC2R) expressed in the fasciculate and reticular zones of the adrenal cortex (39, 43), and triggers intracellular signaling pathways regulating the adrenal cortisol production. Acute administrations of ACTH fragments increase fighting in mice, independently of corticosterone secretion (44), but ACTH injections in isolated mice may also decrease their aggressiveness (45). It was shown that there is a link between ACTH and aggressive behavior (46), and recently this link has been strengthened through studies on ACTH autoAbs (34).…”

Section: Adrenocorticotrophic Hormonementioning

confidence: 99%

Neurobiology of Aggressive Behavior—Role of Autoantibodies Reactive With Stress-Related Peptide Hormones

2019

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Adrenocorticotropic hormone together with arginine vasopressin and oxytocin, the neuropeptides regulating the stress response and the hypothalamic-pituitary-adrenal axis activity, are known to modulate aggressive behavior. The functional role of the adrenocorticotropic hormone immunoglobulin G autoantibodies in peptidergic signaling and motivated behavior, including aggression, has been shown in experimental and in vitro models. This review summarizes some experimental data implicating autoantibodies reactive with stress-related peptides in aggressive behavior.

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Acute influences of some ACTH-related peptides on fighting and adrenocortical activity in male laboratory mice

Cited by 41 publications

References 24 publications

A role for glucocorticoids in the long-term establishment of a social hierarchy

A role for glucocorticoids in the long-term establishment of a social hierarchy

Short‐day aggression is independent of changes in cortisol or glucocorticoid receptors in male Siberian hamsters (Phodopus sungorus)

Neurobiology of Aggressive Behavior—Role of Autoantibodies Reactive With Stress-Related Peptide Hormones

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