Acute inhibition of corticostriatal synaptic transmission in the rat dorsal striatum by ethanol

Choi, Se Joon; Kim, Ki‐Jung; Cho, Hyeong Seok; Kim, Seong Yun; Cho, Young Jin; Hahn, Sang June; Sung, Ki-Wug

doi:10.1016/j.alcohol.2006.12.004

Cited by 16 publications

(18 citation statements)

References 34 publications

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“…Generally, the GluR2-containing AMPA receptor has a linear rectification pattern in comparison to the GluR2-lacking AMPA receptor on the hippocampal neuron (Adesnik and Nicoll, 2007;Derkach et al, 2007). Our results show that the GluR2-containing AMPA receptor has a linear pattern on striatal neurons (Fig.…”

Section: Discussionsupporting

confidence: 58%

“…Generally, GluR2-containing AMPA receptors show properties of Ca 2＋ impermeability, low channel conductance and a linear rectification pattern, whereas GluR2-lacking AMPA receptors exhibit Ca 2＋ permeability, high channel conductance and an inward rectification pattern (Jonas and Burnashev, 1995;Adesnik and Nicoll, 2007;Derkach et al, 2007;Panicker et al, 2008). Moreover, the presence or absence of the GluR2 subunit can alter AMPA receptor properties and synaptic transmission (Derkach et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Brain slices were prepared from 15 to 21-day-old Sprague-Dawley rats using a previously described technique (Choi et al, 2006;Cho et al, 2008). A coronal slice (300 μm thick) containing the cerebral cortex and striatum was produced using a manual vibratome (Campden Insruments, Loughborough, UK).…”

Section: Slice Preparationmentioning

confidence: 99%

“…AMPA receptors consist of GluR1-4 subunits, and the presence or absence of GluR2 subunit characterizes physiological properties of AMPA receptors. For example, GluR2-containing AMPA receptors are Ca 2＋ impermeable and have linear rectification pattern, whereas GluR2-lacking AMPA receptors are Ca 2＋ permeable and have inward rectification pattern (Adesnik and Nicoll, 2007;Derkach et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Electrophysiological Characterization of AMPA and NMDA Receptors in Rat Dorsal Striatum

Jeun

Cho

Kim

et al. 2009

Korean J Physiol Pharmacol

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The striatum receives glutamatergic afferents from the cortex and thalamus, and these synaptic transmissions are mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) and N-methyl-D-aspartate (NMDA) receptors. The purpose of this study was to characterize glutamate receptors by analyzing NMDA/AMPA ratio and rectification of AMPA and NMDA excitatory postsynaptic currents (EPSCs) using a whole-cell voltage-clamp method in the dorsal striatum. Receptor antagonists were used to isolate receptor or subunit specific EPSC, such as (DL)-2-amino-5-phosphonovaleric acid (APV), an NMDA receptor antagonist, ifenprodil, an NR2B antagonist, CNQX, an AMPA receptor antagonist and IEM-1460, a GluR2-lacking AMPA receptor blocker. AMPA and NMDA EPSCs were recorded at − 70 and ＋ 40 mV, respectively. Rectification index was calculated by current ratio of EPSCs between ＋ 50 and − 50 mV. NMDA/AMPA ratio was 0.20±0.05, AMPA receptor ratio of GluR2-lacking/GluR2-containing subunit was 0.26±0.05 and NMDA receptor ratio of NR2B/NR2A subunit was 0.32±0.03. The rectification index (control 2.39±0.27) was decreased in the presence of both APV and combination of APV and IEM-1460 (1.02±0.11 and 0.93±0.09, respectively). These results suggest that the major components of the striatal glutamate receptors are GluR2-containing AMPA receptors and NR2A-containing NMDA receptors. Our results may provide useful information for corticostriatal synaptic transmission and plasticity studies.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Slice Preparationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Electrophysiological Characterization of AMPA and NMDA Receptors in Rat Dorsal Striatum

Jeun

Cho

Kim

et al. 2009

Korean J Physiol Pharmacol

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“…Brain slices were prepared from 14-to 20-day-old Sprague-Dawley rats according to the techniques previously described Choi et al, 2006). Rats were anaesthetized with pentobarbital (50 mg/kg, i.p.)…”

Section: Slice Preparationmentioning

confidence: 99%