2009
DOI: 10.1016/j.tem.2009.06.004
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Acute insulin resistance following injury

Abstract: Hyperglycemia and insulin resistance often occur following injury and/or critical illness. While intensive insulin treatment reduces hyperglycemia, mortality and morbidity in certain patients, little is known regarding the pathophysiology of acute insulin resistance following injury and infection. Studies suggest that acute insulin resistance is complex and may differ in a tissue-specific manner, involving multiple causative factors and intracellular signaling pathways. Therefore, the advantages of intensive i… Show more

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Cited by 90 publications
(86 citation statements)
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“…In acute coronary syndromes, insulin-resistant patients are known to be more prone to hyperglycemia [35,36]. In our series, glucose values (when corrected for HOMA index) are independently associated with in-ICCU BMI body mass index, AMI acute myocardial infarction, LVEF left ventricular ejection fraction, PCI percutaneous coronary intervention, Hb A1c glycated hemoglobin, NT-pro-BNP N terminal-pro-brain natriuretic peptide, eGFR estimated glomerular filtration rate * Fisher's exact test Acta Diabetol mortality (thus confirming previous data by others and us) [4][5][6][7][8][9][10][11] and with in-ICCU complications.…”
Section: Discussionmentioning
confidence: 99%
“…In acute coronary syndromes, insulin-resistant patients are known to be more prone to hyperglycemia [35,36]. In our series, glucose values (when corrected for HOMA index) are independently associated with in-ICCU BMI body mass index, AMI acute myocardial infarction, LVEF left ventricular ejection fraction, PCI percutaneous coronary intervention, Hb A1c glycated hemoglobin, NT-pro-BNP N terminal-pro-brain natriuretic peptide, eGFR estimated glomerular filtration rate * Fisher's exact test Acta Diabetol mortality (thus confirming previous data by others and us) [4][5][6][7][8][9][10][11] and with in-ICCU complications.…”
Section: Discussionmentioning
confidence: 99%
“…Feeding a high fat ketogenic diet, of the Mayo Clinic type, results in large increases in blood cholesterol and LDL cholesterol predisposing the atherosclerosis ( 9 ). Accordingly, to obtain the desirable effect of ketosis in treating Alzheimer's or Parkinson's disease ( 10 ), increasing the ⌬ G ′ of ATP hydrolysis ( 11 ), decreasing and overcoming the insulin resistance present in many acute injuries ( 12 ), or combating free radical toxicity ( 13,14 ); an orally ( 15 ) absorbable ketone body ester was synthesized, which was comprised of the mono-ester of D-␤ -hydroxybutyrate and (R)-1,3-butanediol ( 16 ). An ester was required, because feeding a mole of ketones as the salt or acid would result in undesirable consequences of cation overload or acidosis.…”
mentioning
confidence: 99%
“…However, a number of studies have reported that insulin treatment also increases the incidence of hypoglycemic episodes, which can adversely affect outcomes after trauma (13,30). Moreover, treatment of early hyperglycemia can be more challenging in obese patients, as the dosages of insulin and responses of glucose after insulin administration are difficult to predict and control due to insulin resistance.…”
mentioning
confidence: 99%