Acute Intermittent Porphyria and Pregnancy

Salokannel, Juhani; Rhen, Kurt

doi:10.3109/00016346909156621

Cited by 6 publications

(2 citation statements)

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“…In seven cases, belonging to biochemically verified porphyric families, the post rnortem diagnosis was based on the typical symptoms documented in hospital case histories. We found 17 cases published earlier (27,40,41,54,59) to be members of the families studied by us. They were therefore included in the clinical part of the present study.…”

Section: Patientsmentioning

confidence: 63%

Hereditary Hepatic Porphyrias in Finland

Mustajoki

Koskelo

1976

Journal of Internal Medicine

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The occurrence of hepatic porphyrias --acute intermittent porphyria (AIP) and variegate porphyria (VP)-in Finland has been studied. During a period of 9 years 107 patients with AIP and 45 patients with VP were found. The prevalence of hereditary hepatic porphyrias was calculated to be 3.4per 100 OOO inhabitants. The patients belonged to 42 different families. Eighty-nine patients (59%) had had acute attacks, whereas 63 were symptomless latent cases. Precipitating factors, symptoms and excretion of porphyrins and their precursors did not significantly differ from what has been reported earlier from other parts of the world. A slight fragility of the skin on the back of the hands was noted in some 50% of VP patients. Abnormal sensitivity to sunlight could not be seen in a single case. However, about 50% of patients with VP showed an abnormal reaction when irradiated with artificial ultraviolet light. The difference in the skin symptoms in South African and Finnish VP patients is discussed.

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