Acute intraperitoneal injection of caffeine improves endurance exercise performance in association with increasing brain dopamine release during exercise

The effects of different doses of caffeine on performance, rating of perceived exertion and pain perception in teenagers female karate athletes

“…In the U.S.A., adults ingest an average of 3 mg/kg of caffeine daily in coffee, tea, caffeinated sodas, and many other drinks and food (Sökmen et al, 2008). The popularity of caffeine as an ergogenic aide has increased dramatically over the last decade (Hendrix et al, 2010), Caffeine is the most widely consumed to improve cognitive, physical performance during exercise and has become a popular ergogenic aid among recreational and competitive athletes (Hendrix et al, 2010;Sökmen et al, 2008;Zheng et al, 2014).…”

“…In the U.S.A., adults ingest an average of 3 mg/kg of caffeine daily in coffee, tea, caffeinated sodas, and many other drinks and food (Sökmen et al, 2008). The popularity of caffeine as an ergogenic aide has increased dramatically over the last decade (Hendrix et al, 2010), Caffeine is the most widely consumed to improve cognitive, physical performance during exercise and has become a popular ergogenic aid among recreational and competitive athletes (Hendrix et al, 2010;Sökmen et al, 2008;Zheng et al, 2014).Caffeine is classified as part of the methylxanthine family of drugs (Cechella et al, 2014;Mohr, Nielsen, Bangsbo, 2011) and is extensively consumed by athletes as an ergogenic aid (Backhouse et al, 2011;Mohr, Nielsen, Bangsbo, 2011) since its removal from the World AntiDoping Agency (WADA) prohibited list of substances (Backhouse et al, 2011;Mohr, Nielsen, Bangsbo, 2011). According to the Medical Council of International Olympic Committee (IOC), caffeine is allowed in sports as long as its urinary excretion level is below 12 µg/mL (Bell, Jacobs, Ellerington, 2001).…”

Caffeine and contraction synergistically stimulate 5′-AMP-activated protein kinase and insulin-independent glucose transport in rat skeletal muscle

“…; Zheng et al. ) and humans (Costill et al. ; Graham and Spriet ; Tarnopolsky and Cupido ; Ryu et al.…”

“…Caffeine increases force production during contraction by multiple mechanisms such as increased Ca 2+ release and Ca 2+ permeability in the sarcoplasmic reticulum, increased Ca 2+ sensitivity, and slowing of the sarcoplasmic reticulum Ca 2+ pump (reviewed in Allen and Westerblad 1995;Magkos and Kavouras 2005). Many researchers have reported that caffeine increases exercise performance and delays fatigue in rodents (Ryu et al 2001;Zheng et al 2014) and humans (Costill et al 1978;Graham and Spriet 1995;Tarnopolsky and Cupido 2000;Ryu et al 2001;Simmonds et al 2010). These ergogenic actions of caffeine led us to hypothesize that caffeine stimulates AMPK and glucose transport in contracting states by causing profound changes in the cellular energy status in skeletal muscle.…”

Improvement of Sprint Performance in Wheelchair Sportsmen With Caffeine Supplementation

“…6 Furthermore, a dose of 10 mg/kg caffeine increased dopamine release in the brain of rats and significantly improved run time to fatigue by ~30% compared with saline. 7 The exact mechanisms explaining caffeine's beneficial effects in humans remain unknown; however, nonselective adenosine antagonism has received much support in recent years.…”