Acute Kidney Injury

Basu, Rajit K.

doi:10.1007/978-1-4471-6416-6_15

Cited by 1 publication

(2 citation statements)

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“…AKI induces systemic and organ-specific hemodynamic-, humoral-, and immunologic imbalances, which helps explain why patients are not just dying with AKI, but from AKI. 18 Based on the current findings about different pathways linking kidney injury with distant organs, therapeutic strategies that targeting just a single molecule are less likely to succeed in reducing the AKI-induced distant organ dysfunctions. (Table 1) Understanding the complex interactions between kidney and distant organs should lead to new diagnostics and therapies to improve outcomes in patients with AKI.…”

Section: Resultsmentioning

confidence: 99%

“…(Fig 2) The effects of AKI on lungs are largely due to pulmonary edema, which can be divided into hydrostatic or non-hydrostatic forms. 18 Fluid overload, the major cause of hydrostatic edema, occurs because of decreased urine output and dampened cardiac output, and is traditionally recognized as a major cause of lung dysfunction in AKI patients. Fluid overload has been strongly associated with increased mortality in AKI patients accompanying acute lung injury (ALI), and restrictive fluid management improved the lung function and shortened the time that mechanical ventilation is needed in these patients.…”

Section: Kidney-lung Interactionsmentioning

confidence: 99%

See 1 more Smart Citation

Distant Organ Dysfunction in Acute Kidney Injury: A Review

Lee

Cozzi

Bush

et al. 2018

American Journal of Kidney Diseases

206

156

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Acute kidney injury (AKI) is common in critically ill patients and is associated with increased morbidity and mortality. Dysfunction of other organs is an important cause of poor outcomes from AKI. Ample clinical and epidemiologic data show that AKI is associated with distant organ dysfunction in lung, heart, brain, and liver. Recent advancements in basic and clinical research have demonstrated physiologic and molecular mechanisms of distant organ interactions in AKI, including leukocyte activation and infiltration, generation of soluble factors such as inflammatory cytokines/chemokines, and endothelial injury. Oxidative stress and production of reactive oxygen species, as well as dysregulation of cell death in distant organs, are also important mechanism of AKI-induced distant organ dysfunction. This review updates recent clinical and experimental findings on organ crosstalk in AKI and highlights potential molecular mechanisms and therapeutic targets to improve clinical outcomes during AKI.

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Section: Resultsmentioning

confidence: 99%

Section: Kidney-lung Interactionsmentioning

confidence: 99%