Acute kidney injury: A pediatric experience over 10 years at a tertiary care center

Abstract

Implication for health policy/practice/research/medical education:The etiology of acute kidney injury (AKI) varies in different countries. In a retrospective analysis data of 180 children less than 18 years treated for AKI was studied. We concluded that the mortality is still high in AKI. The poor outcome (defined as low GFR) are higher among patients with low levels of first GFR and higher RIFLE score.Please cite this paper as: Gheissari A, Mehrasa P, Merrikhi A, Madihi Y. Acute kidney injury: A pediatric experience over 10 years at a tertiary care center. J Nephropathology. 2012; 1 (2) Results: The male to female ratio was 1.57 to 1. Mean age was 5.28 ± 6.3 (SD) years and the median was 1.8 years. The more frequent age group was children less than 2 years. The mortality rate was 22.2% (40 patients). The mortality was not correlated with age (p= 0.74). Renal replacement therapy was recommended for 62 patients (34.4%). Mean of the first and last glomerular filtration rate (GFR) were 18.33± 1.12 ml/min/1.73 m² and 52.53 ± 2.98 ml/min/1.73 m², respectively. The most common urinary sediment finding in approximately 70% of the patients was either renal epithelial cell or renal cell cast. Increased kidney echogenicity was the most common ultrasound finding (48%). Using ANOVA regression analysis, the etiology of disease was the only predictor of mortality (p=0.0001). Conclusions:We concluded that the mortality is still high in AKI. Furthermore, the poor outcome (defined as low GFR) are higher among patients with low levels of first GFR and higher RIFLE score.

Age and Dialysis Adequacy in Maintenance Hemodialysis Patients

“…It was found that life expectancy of the patients who began dialysis above 75 years old was significantly shorter than the patients who started dialysis between 50 and 60 years of age, especially if they had low weight, lost weight loss and/or required hospitalization [43]. Negative association of age with dialysis efficiency seriously influences the life expectancy of older patients [1][2][3][4][5][6]. We showed the negative association of age and predialysis serum creatinine.…”

“…Trends have changed and now over 35% of chronic dialysis patients are 65 or older, when starting dialysis therapy [1][2][3][4][5][6]. Currently, there are around one million chronic dialysis patients worldwide [3][4][5][6][7].…”

“…Until recently, elderly patients were offered renal replacement therapy, either in the acute or chronic stages of their illness [1][2][3]. Trends have changed and now over 35% of chronic dialysis patients are 65 or older, when starting dialysis therapy [1][2][3][4][5][6].…”

A Rare Cause of Acute Renal Damage Followed by an Initial Diagnosis of STEC HUS: Rhabdomyolysis: Case Report

“…[1][2][3][4][5] Almanya 2011 salgınından sonra Türkiye'de yaşanan kısmi salgın ve farkındalığın artması nedeni ile diyare ilişkili hemolitik üremik sendromu (D+HÜS) daha sık görülmeye başlanmıştır. 6,7 Ancak HÜS tanısı koyarken tanı kriterleri dikkatle değerlendirilmediği takdirde akut renal zedelenme nedeni atlanabilmekte ve hastanın tedavisi gecikebilmektedir.…”

C-Phycocyanin attenuates cisplatin-induced nephrotoxicity in mice

“…Hence, it is well established that there is a gender difference in the cisplatin renal toxicity in rat model. Indeed, it is well recognized that some conditions that lead to chronic kidney diseases are sex related too; [5][6][7][8][9][11][12][13] however, few studies published regarding gender difference in cisplatin renal toxicity . However, there still needs to be more investigations, mechanisms take part in cisplatin renal toxicity especially on gender difference.…”