Acute kidney injury and cardiac arrhythmia as the presenting features of widespread diffuse large B-cell lymphoma

Abstract

Diffuse Large B-cell Lymphoma, the most common adult non-Hodgkin lymphoma, is a proliferative neoplasm of enlarged B cells. Patients may be asymptomatic on presentation, but if present, symptoms often correlate with direct organ dysfunction resulting from the site of involvement. While the gastrointestinal system is the most common site of extranodal involvement, virtually any part of the body can be infiltrated by malignant lymphocytes. Here, we present an unusual case of cardiac and bilateral renal involvement by Diffuse Large B-cell Lymphoma in a 78-year-old male with a relatively unremarkable medical history. This combination of organ involvement and the resulting clinical symptoms are uncommonly described in the literature. The patient was treated for his symptoms prior to death, but the underlying cause that explained his presentation was not identified until performance of an autopsy. As such, this case demonstrates the utility of the medical autopsy, a gold standard in diagnostic medicine that can provide a variety of benefits in today’s healthcare system.

Primary Diffuse Large B-Cell Lymphoma of the Female Urethra: A Case Report and Review of the Literature

“… 8 Two-thirds of patients with DLBCL were cured with standard immunochemotherapy, but a proportion of them did not respond to the initial treatment or may relapsed, 39 and most relapses occurred within 1 to 2 years after diagnosis. 2 Patients with DLBCL who are event-free at 2 years have an identical OS to that of the general population. 35 Table 1 shows that although most patients have not been followed up for a long time, those whose tumors have not spread have a good prognosis after surgical resection and chemotherapy (one patient has had no disease recurrences after 48 months of follow-up 24 ).…”

“… 1 DLBCL occurs mainly in the lymphatic system, and the most common site is the gastrointestinal tract, followed by the skin, and central nervous system. 2 Malignant lymphomas involving the urogenital tract are rare, and more than 90% of these are secondary to other primary disease. The most common site of primary urogenital NHL is the bladder.…”