Acute kidney injury and electrolyte disorders in COVID-19

Nogueira, Gabriel Martins; Silva, Noel Lucas Oliveira Rodrigues; Moura, Ana Flávia; Silveira, Marcelo Augusto Duarte; Moura-Neto, José A.

doi:10.5501/wjv.v11.i5.283

Cited by 6 publications

(4 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A relationship between serum CRP and sodium concentration has been observed in other infectious diseases and has also been demonstrated in patients with COVID-19 17 28 41. This phenomenon has been attributed to release of cytokines such as interleukin 6 and interleukin 1β,47 which can affect the secretion of ADH and potentially contribute to the development of SIADH 23 48. In patients with COVID-19, elevated levels of interleukin 6 and interleukin 1β have been noted 30 49 50.…”

Section: Discussionmentioning

confidence: 82%

What is the aetiology of dysnatraemia in COVID-19 and how is this related to outcomes in patients admitted during earlier and later COVID-19 waves? A multicentre, retrospective observational study in 11 Dutch hospitals

de Haan,

ten Wolde,

Beudel

et al. 2023

BMJ Open

View full text Add to dashboard Cite

ObjectivesTo evaluate the relationship among dysnatraemia at hospital presentation and duration of admission, risk of intensive care unit (ICU) admission and all-cause mortality and to assess the underlying pathophysiological mechanism of hyponatraemia in patients with COVID-19. Our hypothesis is that both hyponatraemia and hypernatraemia at presentation are associated with adverse outcomes.DesignObservational study.SettingSecondary care; 11 Dutch hospitals (2 university and 9 general hospitals).ParticipantsAn analysis was performed within the retrospective multicentre cohort study COVIDPredict. 7811 patients were included (60% men, 40% women) between 24 February 2020 and 9 August 2022. Patients who were ≥18 years with PCR-confirmed COVID-19 or CT with COVID-19 reporting and data system score≥4 and alternative diagnosis were included. Patients were excluded when serum sodium levels at presentation were not registered in the database or when they had been transferred from another participating hospital.Outcome measuresWe studied demographics, medical history, symptoms and outcomes. Patients were stratified according to serum sodium concentration and urinary sodium excretion.ResultsHyponatraemia was present in 2677 (34.2%) patients and hypernatraemia in 126 (1.6%) patients. Patients with hyponatraemia presented more frequently with diarrhoea, lower blood pressure and tachycardia. Hyponatraemia was, despite a higher risk for ICU admission (OR 1.27 (1.11–1.46; p<0.001)), not associated with mortality or the risk for intubation. Patients with hypernatraemia had higher mortality rates (OR 2.25 (1.49–3.41; p<0.001)) and were at risk for ICU admission (OR 2.89 (1.83–4.58)) and intubation (OR 2.95 (1.83–4.74)).ConclusionsHypernatraemia at presentation was associated with adverse outcomes in patients with COVID-19. Hypovolaemic hyponatraemia was found to be the most common aetiology of hyponatraemia. Hyponatraemia of unknown aetiology was associated with a higher risk for ICU admission and intubation and longer duration of admission.

show abstract

Section: Discussionmentioning

confidence: 82%

What is the aetiology of dysnatraemia in COVID-19 and how is this related to outcomes in patients admitted during earlier and later COVID-19 waves? A multicentre, retrospective observational study in 11 Dutch hospitals

de Haan,

ten Wolde,

Beudel

et al. 2023

BMJ Open

View full text Add to dashboard Cite

show abstract

“…Acute kidney injury may occur in a significant number of COVID-19 patients 27 . The mechanism of acute kidney injury is multifactorial, involving endothelial dysfunction with coagulative dysfunction, organ crosstalk, drug nephrotoxicity, cytokine release syndrome (a complex process driven by virus-mediated injury), rhabdomyolysis, and renin–angiotensin–aldosterone system impairment 27 , 28 . It is known that some medications already tested in patients with COVID-19 may be associated with an increased risk of acute kidney injury 29 .…”

Section: Discussionmentioning

confidence: 99%

Standardized Brazilian green propolis extract (EPP-AF®) in COVID-19 outcomes: a randomized double-blind placebo-controlled trial

Silveira,

Menezes,

de Souza

et al. 2023

Sci Rep

View full text Add to dashboard Cite

SARS-CoV-2 and its different variants caused a “wave and wave” pandemic pattern. During the first wave we demonstrated that standardized Brazilian green propolis extract (EPP-AF®) reduces length of hospital stay in adult patients with COVID-19. Afterwards, we decided to evaluate the impact of EPP-AF in hospitalized patients during the third wave of the pandemic. BeeCovid2 was a randomized, double-blind, placebo-controlled clinical trial in hospitalized COVID-19 adult patients. Patients were allocated to receive an oral dose of 900 mg/day of EPP-AF® or placebo for 10 days. The primary outcome was length of hospital stay. Secondary outcomes included safety, secondary infection rate, duration of oxygen therapy dependency, acute kidney injury and need for intensive care. Patients were followed up for 28 days after admission. We enrolled 188 patients; 98 were assigned to the propolis group and 90 to the placebo group. The post-intervention length of hospital stay was of 6.5 ± 6.0 days in the propolis group versus 7.7 ± 7.1 days in the control group (95% CI − 0.74 [− 1.94 to 0.42]; p = 0.22). Propolis did not have significant impact on the need for oxygen supplementation or frequency of AKI. There was a significant difference in the incidence of secondary infection between groups, with 6.1% in the propolis group versus 18.9% in the control group (95% CI − 0.28 [0.1–0.76], p = 0.01). The use of EPP-AF was considered safe and associated with a decrease in secondary infections. The drug was not associated with a significant reduction in length of hospital stay. ClinicalTrials.gov (NCT04800224).

show abstract

“…In addition, acute kidney injury (AKI) and electrolyte disturbances are important complications of hospitalized COVID-19 patients. AKI is thought to occur due to multiple pathophysiological mechanisms, such as multiple organ dysfunction, direct viral entry into the renal tubules, and cytokine release syndrome [53]. BUN is reported in many cases of AKI and was significantly higher in severe cases of COVID-19 [54].…”

Section: Discussionmentioning

confidence: 99%

Hematological and Biochemical Laboratory Parameters in COVID‐19 Patients: A Retrospective Modeling Study of Severity and Mortality Predictors

Alizad,

Ayatollahi,

Shariati Samani

et al. 2023

BioMed Research International

View full text Add to dashboard Cite

Background. It is well known that laboratory markers could help in identifying risk factors of severe illness and predicting outcomes of diseases. Here, we performed a retrospective modeling study of severity and mortality predictors of hematological and biochemical laboratory parameters in Iranian COVID-19 patients. Methods. Data were obtained retrospectively from medical records of 564 confirmed Iranian COVID-19 cases. According to the disease severity, the patients were categorized into two groups (severe or nonsevere), and based on the outcome of the disease, patients were divided into two groups (recovered or deceased). Demographic and laboratory data were compared between groups, and statistical analyses were performed to define predictors of disease severity and mortality in the patients. Results. The study identified a panel of hematological and biochemical markers associated with the severe outcome of COVID-19 and constructed different predictive models for severity and mortality. The disease severity and mortality rate were significantly higher in elderly inpatients, whereas gender was not a determining factor of the clinical outcome. Age-adjusted white blood cells (WBC), platelet cells (PLT), neutrophil-to-lymphocyte ratio (NLR), red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT), erythrocyte sedimentation rate (ESR), mean corpuscular hemoglobin (MCHC), blood urea nitrogen (BUN), and creatinine (Cr) also showed high accuracy in predicting severe cases at the time of hospitalization, and logistic regression analysis suggested grouped hematological parameters (age, WBC, NLR, PLT, HGB, and international normalized ratio (INR)) and biochemical markers (age, BUN, and lactate dehydrogenase (LDH)) as the best models of combined laboratory predictors for severity and mortality. Conclusion. The findings suggest that a panel of several routine laboratory parameters recorded on admission could be helpful for clinicians to predict and evaluate the risk of disease severity and mortality in COVID-19 patients.

show abstract

Acute kidney injury and electrolyte disorders in COVID-19

Cited by 6 publications

References 85 publications

What is the aetiology of dysnatraemia in COVID-19 and how is this related to outcomes in patients admitted during earlier and later COVID-19 waves? A multicentre, retrospective observational study in 11 Dutch hospitals

What is the aetiology of dysnatraemia in COVID-19 and how is this related to outcomes in patients admitted during earlier and later COVID-19 waves? A multicentre, retrospective observational study in 11 Dutch hospitals

Standardized Brazilian green propolis extract (EPP-AF®) in COVID-19 outcomes: a randomized double-blind placebo-controlled trial

Hematological and Biochemical Laboratory Parameters in COVID‐19 Patients: A Retrospective Modeling Study of Severity and Mortality Predictors

Contact Info

Product

Resources

About