Acute Kidney Injury and Hepatorenal Syndrome in Patients with Cirrhosis

Ozturk, Nazli Begum; Dinc, Ece Janet; Swami, Abhishek; Gurakar, Ahmet

doi:10.3390/jcm13010199

Cited by 2 publications

(1 citation statement)

References 70 publications

(139 reference statements)

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“…Zirkulatorische Ursachen (vorwiegend Hypoperfusion) werden ebenfalls für die Mehrzahl der Fälle eines akuten und chronischen Nierenversagens beim hepatorenalen Syndrom postuliert [ 24 ]. Doch auch andere metabolische Prozesse wie Adipositas werden zunehmend als Ursache renaler Erkrankungen erkannt.…”

Section: Keine Systemische Erkrankung Ohne Nierenbeteiligungunclassified

Renal involvement in systemic diseases

Kain

2024

Pathologie

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Zusammenfassung Hintergrund Erkrankungen des nicht-neoplastischen Nierenparenchyms können im Rahmen aller, den Organismus systemisch betreffenden Erkrankungen auftreten und stellen so eine Differenzialdiagnose für immunologisch bedingte Nierenerkrankungen dar. Fragestellung Zwei häufige autoimmunologische Erkrankungen der Niere – antineutrophile Zytoplasmaantikörper (ANCA)-assoziierte Vaskulitis (AAV) und systemischer Lupus erythematosus (SLE) – werden im Kontext des breiten Erkrankungsfelds der Nieren und deren diagnostische und mögliche therapeutische Ansätze dargestellt. Material und Methoden Es wird eine Übersicht über die Krankheitsbilder mit Review aktueller Literatur gegeben.

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Section: Keine Systemische Erkrankung Ohne Nierenbeteiligungunclassified

Renal involvement in systemic diseases

Kain

2024

Pathologie

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Persistent acute kidney injury: Postoperative impact and predictors in patients undergoing liver resection

Doi,

Yasuda,

Nagai

et al. 2024

Hepatology Research

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AimPersistent acute kidney injury (AKI) has not been investigated in patients undergoing liver resection. We aimed to identify the predictors of persistent AKI, its effect on postoperative outcomes and long‐term renal function in patients following liver resection, and its impact on survival in patients with hepatocellular carcinoma (HCC).MethodsWe examined 990 patients who underwent liver resection, including a subgroup analysis of 384 patients with curative resection for initial HCC. Persistent AKI was defined as residual impairment of serum creatinine ≥ 0.3 mg/dL or ≥50% from baseline 1 month after surgery.ResultsThe persistent AKI group had significantly worse postoperative outcomes, including overall morbidity, major morbidity, longer hospital stay, and 90‐day mortality. In the subgroup analysis of patients with HCC, persistent AKI was associated with a significantly poorer overall survival (OS) rate (p < 0.001), and the multivariate analysis confirmed persistent AKI as an independent poor prognostic factor for OS (p = 0.005). The long‐term postoperative estimated glomerular filtration rate decline was significantly greater in the persistent AKI group than in the no AKI and transient AKI groups (p < 0.001 for both). Chronic kidney disease, albumin–bilirubin grade ≥2, and anatomical resection were independent predictors of persistent AKI (p = 0.001, p = 0.039, and p = 0.015, respectively).ConclusionsPersistent AKI adversely affects postoperative outcomes and long‐term renal function in patients undergoing liver resection. Furthermore, it is associated with poor prognosis in patients with HCC. Therapeutic strategies to prevent persistent AKI are critical for improving postoperative outcomes in these patients.

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Acute Kidney Injury and Hepatorenal Syndrome in Patients with Cirrhosis

Cited by 2 publications

References 70 publications

Renal involvement in systemic diseases

Renal involvement in systemic diseases

Persistent acute kidney injury: Postoperative impact and predictors in patients undergoing liver resection

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