2016
DOI: 10.3748/wjg.v22.i42.9314
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Acute kidney injury and post-reperfusion syndrome in liver transplantation

Abstract: In the past decades liver transplantation (LT) has become the treatment of choice for patients with end stage liver disease (ESLD). The chronic shortage of cadaveric organs for transplantation led to the utilization of a greater number of marginal donors such as older donors or donors after circulatory death (DCD). The improved survival of transplanted patients has increased the frequency of long-term complications, in particular chronic kidney disease (CKD). Acute kidney injury (AKI) post-LT has been recently… Show more

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Cited by 50 publications
(40 citation statements)
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“…(31,32,35) Current clinical trials are evaluating the use of IL18 binding protein as well as neutralizing antibodies to IL18 in treating several human diseases including AKI. (36) Postreperfusion syndrome and hemodynamic instability have been associated with the development of AKI after LT. (1,37) However, similarly to other studies, (38,39) we did not find a significant difference in postreperfusion syndrome and hemodynamic instability between the AKI and non-AKI groups. Furthermore, despite previous studies suggesting that peak transaminases are an independent predictor of AKI after LT, (4,38) our study suggests that the ET-1 and IL18 serum levels outperform peak ALT for prognostic determination of AKI after LT.…”
Section: Discussionsupporting
confidence: 87%
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“…(31,32,35) Current clinical trials are evaluating the use of IL18 binding protein as well as neutralizing antibodies to IL18 in treating several human diseases including AKI. (36) Postreperfusion syndrome and hemodynamic instability have been associated with the development of AKI after LT. (1,37) However, similarly to other studies, (38,39) we did not find a significant difference in postreperfusion syndrome and hemodynamic instability between the AKI and non-AKI groups. Furthermore, despite previous studies suggesting that peak transaminases are an independent predictor of AKI after LT, (4,38) our study suggests that the ET-1 and IL18 serum levels outperform peak ALT for prognostic determination of AKI after LT.…”
Section: Discussionsupporting
confidence: 87%
“…Postreperfusion syndrome and hemodynamic instability have been associated with the development of AKI after LT . However, similarly to other studies, we did not find a significant difference in postreperfusion syndrome and hemodynamic instability between the AKI and non‐AKI groups.…”
Section: Discussionsupporting
confidence: 82%
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“…These findings add further support to the hypothesis that DCD livers, once reperfused, trigger a systemic inflammatory response that ultimately causes renal dysfunction. (30) In these transplants, it thus seems advisable to opt for immunosuppression regimens that offer reduced nephrotoxicity and to explore strategies to limit the inflammatory response.…”
Section: Original Article | 1533mentioning
confidence: 99%
“…A renal‐sparing immunosuppressive regimen, consisting of basiliximab and mycophenolate mofetil, was introduced to avoid administration of a calcineurin inhibitor (CNI), as grafts from ECDs often provoke ischemia–reperfusion injury (IRI) and occasionally acute kidney injury (AKI) . The patient unfortunately required relaparotomy for intra‐abdominal bleeding on post‐operative day (POD) 1.…”
Section: Case Reportmentioning
confidence: 99%