Acute Kidney Injury by Arsine Poisoning: The Ultrastructural Pathology of the Kidney

Lee, Joon Young; Eom, Minseob; Yang, Jae Won; Han, Byoung Geun; Choi, Seung Ok; Kim, Jae‐Seok

doi:10.3109/0886022x.2012.745117

Cited by 17 publications

(8 citation statements)

References 8 publications

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“…[12][13][14][15][16][17][18][19] There are numerous animal models that have been used to elucidate the pathological mechanisms of kidney disease. [19][20][21] Those induced by ischemia, 14,22,23 lipopolysaccharide, [24][25][26][27] cisplatin, [28][29][30] arsenic, [31][32][33] adenine, [34][35][36] cadmium 15,[37][38][39][40] and diabetes [41][42][43][44][45][46] are widely used as animal models of kidney disease. These models have also been used to test the therapeutic effect of a given drug or compound.…”

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confidence: 99%

Folic acid‐induced animal model of kidney disease

2021

Anim Models and Exp Med

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Kidney disease may be generally classified clinically into two categories: acute kidney injury (AKI) and chronic kidney disease (CKD), both of which are tightly interconnected. 1-3 AKI can often develop in clinical settings in critically ill patients, leading to increased morbidity and mortality. 4,5 AKI is manifested by a rapid decline in the glomerular filtration rates (GFRs) 6 and its pathogenesis is complex, involving ischemia, sepsis, drug toxicity, and trauma. 7 If left unmanaged, AKI can develop into CKD, which is characterized by a progressive decrease in GFR, culminating in a gradual loss of renal function. 8 The transition from AKI to CKD can also be hastened by numerous risk factors such as obesity, hypertension, diabetes, and chronic inflammation. 9-11 Currently, there are no effective treatments for either AKI or CKD, stressing a continual need to elucidate the underlying pathological mechanisms of AKI and CKD. In this regard, animal models of kidney disease have been invaluable in that utilization of these animal models not only facilitates our understanding of the

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confidence: 99%

Folic acid‐induced animal model of kidney disease

2021

Anim Models and Exp Med

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“…It is well known that the kidney is the organ that is primarily responsible for arsenic excretion; as such, its structure and function are vulnerable to damage. Many studies [2][3][4][5] have shown that arsenic exposure is a risk factor for kidney damage. According to current research, there are two possible mechanisms of kidney damage by arsenic: oxidative stress and apoptosis.…”

Section: Introductionmentioning

confidence: 99%

A possible new mechanism and drug intervention for kidney damage due to arsenic poisoning in rats

Zeng

Yao

et al. 2016

Toxicol. Res.

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Arsenic poisoning is a worldwide endemic disease that affects thousands of people. Currently, the aetiology of the disease is known, but its pathogenesis is uncharacterized and there is no specific treatment. We established a rat model of coal-burning arsenic poisoning by feeding the animals corn powder baked with high arsenic coal. By observing subsequent changes in kidney and immune function, we found that arsenic induces both kidney and immune damage. Furthermore, there is a significant correlation between kidney and immune damage. Moreover, Ginkgo biloba, a known immune enhancer, was used as an intervention agent in arsenic poisoned rats to validate the relationship between kidney and immune damage. Meanwhile, we also explored the mechanism of Ginkgo biloba treatment of kidney damage in burning-coal arsenic poisoned rats. We found that Ginkgo biloba enhanced immune function in rats with arsenic poisoning and ameliorated arsenic-induced kidney damage. These results suggest that immune suppression may be one of the mechanisms underlying arsenic-induced kidney damage and that Ginkgo biloba might relieve kidney damage by enhancing immune function.

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“…Delayed recognition and treatment of sepsis; the unavailability of diagnostics tools or a higher level of care; limited access to antivenom and antibiotics, including highly active antiretroviral therapy; and the inability to provide timely and monitored management of hyperkalemia, acidosis, and fluid overload with diuretics increase AKI incidence, likely escalate the requirements for dialysis treatment, and lead to higher mortality. 13 , 14 Tropical infections, 16 , 21 community-acquired pneumonia or meningitis, pregnancy-related complications (bleeding, eclampsia, septic abortion), 22 , 23 , 24 , 25 , 26 dehydration due to inadequate access to fluids in frail older adults and young children, exposure to nephrotoxins (e.g., nonsteroidal anti-inflammatory drugs, calcineurin blockers, antiretroviral therapy, antibiotics, or contrast media), 27 , 28 , 29 poisons (e.g., arsenic poisoning), 30 drug interactions (e.g., calcium-channel blocker plus clarithromycin), 31 animal venoms (e.g., snake venom), 20 trauma-induced rhabdomyolysis, 32 and shock states due to heart failure, hypovolemia, or sepsis 1 , 16 , 33 are all factors that can result in AKI. AKI following polypharmacy and nephrotoxin exposures in developing countries may be more prevalent, particularly when oversights of pharmacies are not robust due to more limited resources.…”

Section: Methodsmentioning

confidence: 99%

Acute Kidney Injury Risk Assessment: Differences and Similarities Between Resource-Limited and Resource-Rich Countries

Kashani

Macedo

Burdmann

et al. 2017

Kidney International Reports

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The incidence of acute kidney injury (AKI) among acutely ill patients is reportedly very high and has vexing consequences on patient outcomes and health care systems. The risks and impact of AKI differ between developed and developing countries. Among developing countries, AKI occurs in young individuals with no or limited comorbidities, and is usually due to environmental causes, including infectious diseases. Although several risk factors have been identified for AKI in different settings, there is limited information on how risk assessment can be used at population and patient levels to improve care in patients with AKI, particularly in developing countries where significant health disparities may exist. The Acute Disease Quality Initiative consensus conference work group addressed the issue of identifying risk factors for AKI and provided recommendations for developing individualized risk stratification strategies to improve care. We proposed a 5-dimension, evidence-based categorization of AKI risk that allows clinicians and investigators to study, define, and implement individualized risk assessment tools for the region or country where they practice. These dimensions include environmental, socioeconomic and cultural factors, processes of care, exposures, and the inherent risks of AKI. We provide examples of these risks and describe approaches for risk assessments in the developing world. We anticipate that these recommendations will be useful for health care providers to plan and execute interventions to limit the impact of AKI on society and each individual patient. Using a modified Delphi process, this group reached consensus regarding several aspects of AKI risk stratification.

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Acute Kidney Injury by Arsine Poisoning: The Ultrastructural Pathology of the Kidney

Cited by 17 publications

References 8 publications

Folic acid‐induced animal model of kidney disease

Folic acid‐induced animal model of kidney disease

A possible new mechanism and drug intervention for kidney damage due to arsenic poisoning in rats

Acute Kidney Injury Risk Assessment: Differences and Similarities Between Resource-Limited and Resource-Rich Countries

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