Acute kidney injury in a shepherd with severe malaria: a case report

Boushab, Boushab Mohamed; Fall-Malick, Fatim-Zahra; Savadogo, Mamoudou; Basco, Léonardo K.

doi:10.2147/ijnrd.s116377

Cited by 7 publications

(6 citation statements)

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“… Map showing the location of the study site (Kiffa) in southern Mauritania. Previous studies on severe malaria were conducted in Kaedi and Aïoun El Atrouss [ 8 , 11 , 12 ]. Nouakchott is the capital city of Mauritania.…”

Section: Figurementioning

confidence: 99%

“…Although severe malaria cases are commonly observed in the Sahelian regions of the country, there are no published clinical studies on severe malaria in Mauritanian adults, except for a single case report from Aioun El Atrouss [ 8 ]. The aim of the present study was to describe the epidemiological and clinical aspects of severe and complicated malaria in Mauritanian adults in Kiffa, situated in southern Mauritania, and compare the presenting clinical manifestations and clinical outcome.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Features and Mortality Associated with Severe Malaria in Adults in Southern Mauritania

et al. 2020

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Severe malaria in adults is not well-studied in Sahelian Africa. Clinical features and mortality associated with severe Plasmodium falciparum malaria in adult patients hospitalized in Kiffa, southern Mauritania, were analysed. Patients over 15 years old admitted for severe malaria between August 2016 and December 2019 were included in the present retrospective study. The World Health Organization (WHO) criteria were used to define severe malaria. The presenting clinical characteristics and outcome were compared. Of 4266 patients hospitalized during the study period, 573 (13.4%) had a positive rapid diagnostic test for malaria, and 99 (17.3%; mean age, 37.5 years; range 15–79 years; sex-ratio M/F, 2.1) satisfied the criteria for severe malaria. On admission, the following signs and symptoms were observed in more than one-fourth of the patients: fever (98%), impairment of consciousness (81.8%), multiple convulsions (70.7%), cardiovascular collapse (61.6%), respiratory distress (43.4%), severe anaemia ≤ 80 g/L (36.4%), haemoglobinuria (27.3%), and renal failure (25.3%). Patients were treated with parenteral quinine or artemether. Fourteen (14.1%) patients died. Multiple convulsions, respiratory distress, severe anaemia, haemoglobinuria, acute renal failure, jaundice, and abnormal bleeding occurred more frequently (p < 0.05) in deceased patients. Mortality due to severe falciparum malaria is high among adults in southern Mauritania. An adoption of the WHO-recommended first-line treatment for severe malaria, such as parenteral artesunate, is required to lower the mortality rate associated with severe malaria.

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Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical Features and Mortality Associated with Severe Malaria in Adults in Southern Mauritania

et al. 2020

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“…Among patients with severe P. falciparum malaria, in addition to respiratory failure and resulting acidosis, cases of acute kidney injury are often described. There is no evidence that geographical region, where the infection occurred, has an influence on the course (18,19,20). Transient renal dysfunction was observed in our patient, but the criteria for diagnosing an acute kidney injury were not fulfilled.…”

Section: Case Reportmentioning

confidence: 61%

“…Wśród pacjentów z ciężkim przebiegiem malarii wywołanej przez P. falciparum, oprócz niewydolności oddechowej i wynikającej z niej kwasicy, często opisuje się przypadki ostrego uszkodzenia nerek. Nie stwierdzono aby region geograficzny, w którym doszło do zarażenia miał wpływ na przebieg (18,19,20). U omawianego pacjenta obserwowano przejściową dysfunkcję nerek, jednak nie było spełnionych kryteriów będących podstawą do rozpoznania ostrego uszkodzenia nerek.…”

Section: Discussionunclassified

Imported malaria caused by Plasmodium falciparum – case report

2018

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INTRODUCTION.Malaria is caused by the Plasmodium spp. which are spread through Anopheles mosquitoes. Disease is not endemic in Poland currently but can be brought from other countries, mostly from Africa and Asia. The main sign of the disease is fever with shivers repeated periodically. There is highly effective chemoprophylaxis available and treatment, which should be given quickly. CASE REPORT. A 35-year-old man have worked monthly in Nigeria since two years. He was using Malarone chemoprophylaxis, but contrary to recommendations. Patient presented to a hospital after four days of having fever in a medium-serious state. He reported three similar incidents in the past. Physical examination revealed hepatomegaly, depressive state, oliguria and diarrhoea. Lab tests showed DIC with thrombocytopenia, renal injury, liver injury, hypoalbuminemia. ECG indicated myocardial ischemia. Malaria Rapid Test and blood smear confirmed Plasmodium falciparum infection with 9,9% parasitemia. When antimalarial treatment was given, patient condition improved, but after three days in hospital he got pneumonia as a complication of malariaantibiotic admission was committed. Moreover, quinine caused temporary deafness and serological tests revealed chronic HBV infection. After 23-days of hospitalisation the patient was discharged in a good condition. A month later patient went to follow-up and only mild anaemia was shown. CONCLUSIONS. This case shown that even such severe disease like malaria can be cured well without serious complications if patient will be diagnosed quickly. Moreover patient's experience and respecting symptoms improve prognosis. There also should be stronger emphasis on the role of chemoprophylaxis -patient did not use it properly, so it did not have to prevent development of malaria.

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“…Although severe malaria cases are commonly observed in the Sahelian regions of the country, there are no published clinical studies on severe malaria in Mauritanian adults, except for a single case report [8]. The aim of the present study was to describe the epidemiological and clinical aspects of severe and complicated malaria in Mauritanian adults in Kiffa, situated in southern Mauritania, and compare the presenting clinical manifestations and clinical outcome.…”

Section: Introductionmentioning

confidence: 95%

Clinical Features and Mortality Associated with Severe Malaria in Adults in Southern Mauritania

Boushab¹,

Salem²,

Boukhary³

et al. 2020

Preprint

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Severe malaria in adults is not well studied in Sahelian Africa. Clinical features and mortality associated with severe Plasmodium falciparum malaria in adult patients hospitalized in Kiffa, southern Mauritania, were analysed. Patients over 15 years old admitted for severe malaria between August 2016 and December 2019 were included in the present retrospective study. The World Health Organization (WHO) criteria were used to define severe malaria. The presenting clinical characteristics and outcome were compared. Of 4266 patients hospitalized during the study period, 573 (13.4%) had a positive rapid diagnostic test for malaria, and 99 (17.3%; mean age, 37.5 years; range 15–79 years; sex-ratio M/F, 2.1) satisfied the criteria for severe malaria. On admission, the following signs and symptoms were observed in more than one-fourth of the patients: fever (98%), impairment of consciousness (81.8%), multiple convulsions (70.7%), cardiovascular collapse (61.6%), respiratory distress (43.4%), severe anaemia ≤ 80 g/L (36.4%), haemoglobinuria (27.3%), and renal failure (25.3%). Patients were treated with parenteral quinine or artemether. Fourteen (14.1%) patients died. Multiple convulsions, respiratory distress, severe anaemia, haemoglobinuria, acute renal failure, jaundice, and abnormal bleeding occurred more frequently (P < 0.05) in deceased patients. Mortality due to severe falciparum malaria is high among adults in southern Mauritania. An adoption of the WHO-recommended first-line treatment for severe malaria, i.e. parenteral artesunate, is required to lower the mortality rate associated with severe malaria.

show abstract

Acute kidney injury in a shepherd with severe malaria: a case report

Cited by 7 publications

References 9 publications

Clinical Features and Mortality Associated with Severe Malaria in Adults in Southern Mauritania

Clinical Features and Mortality Associated with Severe Malaria in Adults in Southern Mauritania

Imported malaria caused by Plasmodium falciparum – case report

Clinical Features and Mortality Associated with Severe Malaria in Adults in Southern Mauritania

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