Acute kidney injury in Colombian patients with COVID-19 who received kidney support therapy with genius® 90 technology

Abstract

Introduction: Acute kidney injury (AKI) is one of the complications associated with severe COVID-19 infection, and it can present in up to 20% to 40% of the cases; of these, approximately 20% will require renal replacement therapy (RRT). Objective: To establish clinical and laboratory characteristics in a group of patients from Colombia with COVID-19 infection and AKI that received intermittent and prolonged RRT with the GENIUS ® 90 technology in between March and July 2020. Design: Cross-sectional study. Results: 78.9% of participants were men and 21.1% were women. The main comorbidities were the following: Hypertension (65.3%), diabetes mellitus (38.9%), obesity (26.3%), cancer (5.3%), Chronic obstructive pulmonary disease (11.6%), cardiovascular disease (23.2%), active smoking (11.6%). 33.7% had chronic kidney disease (CKD) in the average serum creatinine on admission was 4.4 mg/dl. The following infl ammatory markers were elevated: C-reactive protein (CRP), d-dimer and ferritin (20.3 mg/dl, 931mcg/l and 1174 ng/ml, respectively). 63.5% of patients underwent sustained low-effi ciency dialysis (SLED) (6 to 12 hours) and the rest of the patients (36.35%) underwent conventional hemodialysis (less than 4 hours). The mortality of the total patient sample was 36.9%, lower in patients with CKD than in patients with no previous renal disease history (18.7% and 40.1%, respectively). Conclusion: Renal complications are frequent in patients with severe COVID-19. The development of AKI could be an isolated prognostic marker associated with an increase in mortality in patients with COVID-19, and one of the options is intermittent and prolonged RRT with the GENIUS ® 90 system. Acute kidney injury in Colombian patients with COVID-19 who received kidney support therapy with genius ® 90 technology

Perfil epidemiológico y clínico de pacientes ginecológicas y obstétricas con enfermedad renal en terapia sustitutiva, en una unidad de cuidado crítico

“…a enfermedad renal crónica (ERC) y la lesión renal aguda (LRA) son complicaciones comunes en la unidad de cuidados intensivos (UCI) frecuentemente asociadas a falla orgánica múltiple con una mortalidad alta que alcanza incluso el 50% cuando requiere de terapia de reemplazo renal (TRR) [1]. Se caracterizan por un deterioro de la función renal en un periodo de horas a días en el caso de la LRA, y en un periodo de meses o años en caso de ERC con una incapacidad del riñón para mantener un balance de líquidos y electrólitos y depurar los productos de desecho del metabolismo.…”