Acute kidney injury in COVID-19: a case-report

Mauro, Marco Di; Migliaccio, Marco Giuseppe; Ricciolino, Riccardo; Spiniello, Giorgio; Carfora, Vincenzo; Verde, Nicoletta; Mottola, Filiberto Fausto; Coppola, Nicola

doi:10.1007/s11255-020-02635-3

Cited by 2 publications

(6 citation statements)

References 8 publications

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“…Renal involvement has been recognized as a significant characteristic of COVID-19, including acute renal failure (AKI), and is noted in 20-50% of hospitalized patients. (6)(7)(8)(9)(10)(11) The first patient developed AKI in the three days of admission, while the second and third patients had AKI from the first day of admission. Data from China suggest the incidence of AKI among hospitalized patients with COVID-19 ranges from 5 to 23%, with AKI usually manifesting during the second week of infection.…”

Section: Discussion Smentioning

confidence: 99%

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Treatment Challenge in COVID-19 Patients with Acute Kidney Injury in Hospital

Pratama

Rifai

Sianturi

2022

CRJIM

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Renal, the main characteristic of COVID-19 infection. Acute kidney injury (AKI) has been documented in 20-50% of the hospitalized COVID-19 patients. Renal involvement among COVID-19 patients might be multifactorial. COVID-19 Patients with AKI significantly had higher mortality than patients without AKI. This case series reported severe COVID-19 with respiratory failure and AKI during admission to the hospital. All patients were admitted to the intensive care unit (ICU) and obtained the standard therapeutic protocols according to the COVID-19 severities. The first patient developed AKI in the three days of admission, while the second and third patients had AKI from the first day of admission. The patients had similar complications, including type 1 or 2 respiratory failures, secondary infection with sepsis, hyperpotassemia, and metabolic acidosis. The first and second patients underwent hemodialysis as indicated on these patients. However, the evaluation of their renal functions did not improve after that. The third patient did not receive the hemodialysis therapy and only obtained supportive treatment with adequate fluid therapy. The third patient was getting better on the 16th day of admission. In addition, the renal function test was getting normal after the 16th day of admission. The patient was discharged on the 19th day of admission in stable condition. Early recognition of renal involvement in COVID-19 infection, preventive measures, renal function monitoring, and therapeutic intervention were essential to reduce the morbidity and mortality of COVID-19 patients. Hospitalized patients should be monitored closely for their renal function to prevent renal function deterioration in the future.

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Section: Discussion Smentioning

confidence: 99%

“…(6) According to Europe and the United States data, AKI is considered a marker of disease severity and an adverse prognostic factor for survival. (7)(8)(9) Handling COVID-19 patients who experience AKI is still a challenge in medical expertise. As many as 20% of patients admitted to the intensive care unit with COVID-19 require renal replacement therapy.…”

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confidence: 99%

Treatment Challenge in COVID-19 Patients with Acute Kidney Injury in Hospital

Pratama

Rifai

Sianturi

2022

CRJIM

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“…Myeloma can be preceded by the premalignant phase, where clonal plasma cells already exist but there is no evidence of end-organ damage (this is known as "monoclonal gammopathy of unknown significance" (MGUS) or "smoldering myeloma"). (2,7,8) The hallmark of most cases of multiple myeloma is the continuous production of some form of immunoglobulin, both in the form of complete antibodies and a separate component of monoclonal antibodies. (6,8) This protein is often detected by serum protein electrophoresis.…”

Section: Discussion Smentioning

confidence: 99%

“…(2,7,8) The hallmark of most cases of multiple myeloma is the continuous production of some form of immunoglobulin, both in the form of complete antibodies and a separate component of monoclonal antibodies. (6,8) This protein is often detected by serum protein electrophoresis. Measurement of monoclonal immunoglobulins in circulation has become the standard for diagnosis, prognosis, and c a b d management.…”

Section: Discussion Smentioning

confidence: 99%

“…(9) Based on these results, the patient Ms. SK, 36 years of age meet the criteria of the Re-vised International Myeloma Working Group, namely plasmacytoma in tissue biopsy with signs of organ damage related to plasma proliferative disease based on the distribution of monoclonal immunoglobulins, multiple myeloma in these patients are classified as nonsecretory. (8) There are several groups of nonsecretory multiple myeloma. Patients who are nonproducers.…”

Section: • Diarrhea • Carpal Tunnel Syndromementioning

confidence: 99%

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Diagnosing Non–Producers Non–Secretory Myeloma

Nurarifah

Wardhani

2023

CRJIM

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Multiple myelomas (MM) is the proliferation of malignant plasma cells in the bone marrow, characterized by the production of monoclonal immunoglobulins that are secreted in the blood and urine. However, in 1 - 5% of cases, the protein is undetectable and defined as non-secretory type of myeloma. A 36-year-old woman presented with complaints of weakness in both legs so she could not walk. She also felt pain in the head, back, and thighs since one year before. Physical examination showed anemic conjunctiva, gibus as high as T4, hypoesthesia as high as T6 segment. She had anemia (Hb 10.2 g/dL), decreased kidney function (eGFR: 30 mL/min/1.73m2), and multiple lytic lesions in the calvaria, ribs, superior-inferior pubic ramus, and left humeral os in the 1/3 proximal to 1/3 distal. Protein electrophoresis and Bence Jonce protein were negative. There was no hypercalcemia, and bone marrow aspiration showed myelodysplasia syndrome. A thoracolumbar MRI showed an extradural solid mass and the histopathology examination result was plasmacytoma. Non-secretory MM was defined into two groups, non-producers and multiple non-secretory myeloma patients who produce tumor proteins but cannot be excreted. This patients was categorized as non-producers non-secretory MM because she did not show a protein that can be measured in blood nor urine, but has significant plasma cells in tissue biopsy. The absence of paraprotein in the blood does not rule out multiple myeloma. Suspicion of multiple myeloma needs to be increased in patients who have symptoms of CRAB (calcium, renal impairment, anemia, bone lytic).

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Acute kidney injury in COVID-19: a case-report

Cited by 2 publications

References 8 publications

Treatment Challenge in COVID-19 Patients with Acute Kidney Injury in Hospital

Treatment Challenge in COVID-19 Patients with Acute Kidney Injury in Hospital

Diagnosing Non–Producers Non–Secretory Myeloma

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