Acute kidney injury in hospitalized patients with methanol intoxication: National Inpatient Sample 2003-2014

Petnak, Tananchai; Kaewput, Wisit; Mao, Michael A; Boonpheng, Boonphiphop; Vallabhajosyula, Saraschandra; Lertjitbanjong, Ploypin; Qureshi, Fawad; Cheungpasitporn, Wisit

doi:10.1080/21548331.2021.1882239

Cited by 6 publications

(6 citation statements)

References 26 publications

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“…Among these factors, coma and elevated creatinine levels above the normal range were the strongest predictors of mortality following methanol intoxication, with ORs of 13.10 and 32.73, respectively. Chang et al demonstrated that serum creatinine concentration due to methanol intoxication is a significant risk factor for acute kidney injury (AKI) [25], which can cause mortality due to renal impairment [26,27]. A systematic review by Gharaeikhezri et al [28] showed that methanol poisoning is associated with a 28.18% prevalence of AKI.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Mortality in Methanol Poisoning: A Systematic Review and Meta-analysis

Gheshlaghi,

Rezaei,

Eizadi-Mood

et al. 2024

IJMTFM

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Background: Today, methanol intoxication is increasing. Identifying mortality predictors has a significant correlation with poisoning progress. This meta-analysis study aimed to identify and evaluate mortality predictors for methanol poisoning. Methods: In this study, we searched electronic databases for case-control and cohort studies related to methanol poisoning. The quality of the studies was evaluated using the STROBE checklist. Comprehensive meta-analysis 3 was used to calculate the odds ratio (OR) and 95% CI of the factors present, as well as to perform heterogeneity, sensitivity, and publication bias assessments. Results: In this meta-analysis study, 14 out of 945 initial studies were included. The results identified 15 mortality predictors of methanol poisoning. The risk factors were ranked by the integrated OR values and included venous blood pH (OR=3.79, 95% CI, 2.42%, 5.19%), methanol concentration (OR=1.64, 95% CI, 1.05%, 2.55%), venous carbon dioxide pressure (PCO2) (OR=9.993, 95% CI, 5.80%, 17.18%), base deficit (OR=2.943, 95% CI, 1.20%, 7.165%), hemodialysis time (OR=2.69, 95% CI, 1.35%, 5.35%), blood sugar (OR=9.84, 95% CI=3.86, 25.09), venous bicarbonate (HCO3) (OR=2.97, 95% CI, 1.68%, 5.26%), creatinine (OR=13.10, 95% CI, 2.68%, 64.04%), potassium (K) (OR=3.51, 95% CI, 1.66%, 7.43%), alanine aminotransferase (OR=7.57, 95% CI, 1.03%, 55.57%), sodium (OR=6.69, 95% CI, 1.78%, 25.12%), white blood cells (OR=7.16, 95% CI, 1.42%, 36.16%), coma (OR=32.73, 95% CI, 18.59%, 56.70%), visual disturbances (OR=3.37, 95% CI, 1.59%, 7.16%), and gastrointestinal symptoms (OR=1.94, 95% CI, 1.16%, 3.22%). Conclusion: Identifying mortality predictors and disease progression in methanol intoxication patients can help doctors diagnose patients at risk better and faster to provide effective treatment interventions for them.

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Section: Discussionmentioning

confidence: 99%

Predictors of Mortality in Methanol Poisoning: A Systematic Review and Meta-analysis

Gheshlaghi,

Rezaei,

Eizadi-Mood

et al. 2024

IJMTFM

View full text Add to dashboard Cite

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“…The second possibility involves patients with respiratory and circulatory system failure (Thongprayoon et al, 2021). This can be observed from the laboratory results showing AGD pH 7.157, PCO2 31.8 mmHg, PO2 163 mmHg, HCO3 11.3 mEq per liter, BE -17, and SpO2 88%.…”

Section: Discussionmentioning

confidence: 99%

“…Another study revealed that methanol poisoning induces severe symptoms in the central nervous system, primarily due to dysfunction of the Na-K pump. This malfunction of the Na-K pump also leads to cerebral edema and, in severe cases, cerebral hemorrhage (Thongprayoon et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

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Differences in Methanol Intoxication Patient Outcomes in First Admission and Re-admission: A Case Report

Ramdani,

Endah Tri Wulandari,

Sobran Jamil

et al. 2023

Indones. J. Nurs. Sci.

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"Oplosan Liquor" is an Indonesian term that refers to illegally made alcoholic beverages created by mixing ethanol or alcohol with other ingredients. The ethanol content in these beverages is uncontrolled and can pose a significant threat to human health. Consuming oplosan liquor with high levels of ethanol can cause alcohol poisoning and, in extreme cases, death. Methanol intoxication can impact patient outcomes, influencing factors such as appropriate treatment, adequate medical and psychological support, and the patient’s ability to avoid future methanol exposure. Differences in outcomes exist between patients mitted for the first time and those experiencing readmission. This case report aims to elucidate the unique distinctions in patient outcomes between those admitted for the first time and those readmitted after methanol intoxication. Materials and Methods: This case report describes an instance that occurred in the same patient, detailing their medical history, clinical symptoms, diagnostic tests, and treatment provided during their stay in the emergency department. Variances in outcomes were observed between two patients, with one succumbing to the effects and the other managing to survive. We share our experience in treating a patient with methanol intoxication during their initial admission and subsequent readmission to a hospital in Indonesia. Indonesian people are acquainted with a drink called "Oplosan Liquor," which is fermented to achieve an alcohol content of up to 90%. This beverage is consumed by many young people who lack knowledge about the use of alcoholic beverages.

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“…Previous studies have documented drug induced-rhabdomyolysis owing to the overuse of methanol, ethanol, methadone, opioid, cocaine, amphetamine, methamphetamine, ecstasy, synthetic cannabinoids, heroin, and tramadol 4 , 5 . Rhabdomyolysis is a syndrome characterized by muscle necrosis and the release of intracellular muscle constituents into circulation 6 .…”

Section: Introductionmentioning

confidence: 99%

Incidence of rhabdomyolysis occurrence in psychoactive substances intoxication: a systematic review and meta-analysis

Amanollahi,

Babeveynezhad,

Sedighi

et al. 2023

Sci Rep

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Rhabdomyolysis is a potentially life-threatening condition induced by diverse mechanisms including drugs and toxins. We aimed to investigate the incidence of rhabdomyolysis occurrence in intoxicated patients with psychoactive substances. In this review, three databases (PubMed, Scopus, Web of Science) and search engine (Google Scholar) were searched by various keywords. After the screening of retrieved documents, related data of included studies were extracted and analyzed with weighted mean difference (WMD) in random effect model. The highest incidence of rhabdomyolysis was observed in intoxication with heroin (57.2 [95% CI 22.6–91.8]), amphetamines (30.5 [95% CI 22.6–38.5]), and cocaine (26.6 [95% CI 11.1–42.1]). The pooled effect size for blood urea nitrogen (WMD = 8.78, p = 0.002), creatinine (WMD = 0.44, p < 0.001), and creatinine phosphokinase (WMD = 2590.9, p < 0.001) was high in patients with rhabdomyolysis compared to patients without rhabdomyolysis. Our results showed a high incidence of rhabdomyolysis induced by psychoactive substance intoxication in ICU patients when compared to total wards. Also, the incidence of rhabdomyolysis occurrence was high in ICU patients with heroin and amphetamine intoxication. Therefore, clinicians should anticipate this complication, monitor for rhabdomyolysis, and institute appropriate treatment protocols early in the patient’s clinical course.

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Acute kidney injury in hospitalized patients with methanol intoxication: National Inpatient Sample 2003-2014

Cited by 6 publications

References 26 publications

Predictors of Mortality in Methanol Poisoning: A Systematic Review and Meta-analysis

Predictors of Mortality in Methanol Poisoning: A Systematic Review and Meta-analysis

Differences in Methanol Intoxication Patient Outcomes in First Admission and Re-admission: A Case Report

Incidence of rhabdomyolysis occurrence in psychoactive substances intoxication: a systematic review and meta-analysis

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