Acute kidney injury in idiopathic membranous nephropathy with nephrotic syndrome

Chen, Tianxin; Zhou, Ying; Chen, Xinxin; Chen, Bin; Pan, Jingye

doi:10.1080/0886022x.2021.1942913

Cited by 7 publications

(10 citation statements)

References 36 publications

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“…Between Jan 2012 to Dec 2018, a retrospective derivation cohort of PMN with AKI was established and described in our previous study [ 9 ]. The validation cohort using the same criteria was identified from the Nephrology Department, the First Affiliated Hospital of Wenzhou Medical University between Jan 2019 to Dec 2020.…”

Section: Methodsmentioning

confidence: 99%

“…Patients would have follow-up for at least 12 months after discharge from hospital. Except the data reported in previous study [ 9 ], the comorbidity of infection, thrombosis, diabetes and hypertensive nephropathy and laboratory data of Anti-Phospholipase A2 receptor (Anti-PLA2R) antibody were collected in this study.…”

Section: Methodsmentioning

confidence: 99%

“…Our previous study showed the incidence of AKI in PMN was similar to that in MCD. Compared with AKI in MCD, AKI in PMN was usually mild and easy to be overlooked but had lower renal function recovery rate [ 1 , 9 ]. The present study builds upon our previous findings by conducting continuous follow-up of AKI patients in PMN with NS.…”

Section: Introductionmentioning

confidence: 99%

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Prediction model of renal function recovery for primary membranous nephropathy with acute kidney injury

et al. 2022

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Background and objectives The clinical and pathological impact factors for renal function recovery in acute kidney injury (AKI) on the progression of renal function in primary membranous nephropathy (PMN) with AKI patients have not yet been reported, we sought to investigate the factors that may influence renal function recovery and develop a nomogram model for predicting renal function recovery in PMN with AKI patients. Methods Two PMN with AKI cohorts from the Nephrology Department, the First Affiliated Hospital of Wenzhou Medical University during 2012–2018 and 2019–2020 were included, i.e., a derivation cohort during 2012–2018 and a validation cohort during 2019–2020. Clinical characteristics and renal pathological features were obtained. The outcome measurement was the recovery of renal function within 12 months. Lasso regression was used for clinical and pathological features selection. Prediction model was built and nomogram was plotted. Model evaluations including calibration curves were performed. Result Renal function recovery was found in 72 of 124 (58.1%) patients and 41 of 72 (56.9%) patients in the derivation and validation cohorts, respectively. The prognostic nomogram model included determinants of sex, age, the comorbidity of hypertensive nephropathy, the stage of glomerular basement membrane and diuretic treatment with a reasonable concordance index of 0.773 (95%CI,0.716–0.830) in the derivation cohort and 0.773 (95%CI, 0.693–0.853) in the validation cohort. Diuretic use was a significant impact factor with decrease of renal function recovery in PMN with AKI patients. Conclusion The predictive nomogram model provides useful prognostic tool for renal function recovery in PMN patients with AKI.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Prediction model of renal function recovery for primary membranous nephropathy with acute kidney injury

et al. 2022

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“…At present, it is believed that the occurrence of AKI may be related to intrarenal ischemia, renal interstitial edema, glomerular lesions, renal tubular necrosis, drug-related interstitial nephritis, etc. [ 7 , 8 ] However, most of the reported studies are focused on the adult population, the clinical features and common pathological types of children with PNS are very different from those of adults with PNS. There are few reports on the relationship between the risk of adult AKI with PNS and changes in the pathological characteristics of the kidneys [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Acute kidney injury in patients with primary nephrotic syndrome: influencing factors and coping strategies

et al. 2022

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Background Acute kidney injury (AKI) is a frequent and serious complication in patients with primary nephrotic syndrome (PNS). We aimed to evaluate the influencing factors of AKI in patients with PNS, to provide implications for the clinical management and nursing care of patients with PNS. Methods PNS patients who were treated in the Department of Nephrology in our hospital from January 1, 2020 to July 31, 2021 were included. The clinical characteristics and pathological type of PNS patients were evaluated. Pearson correlation and Logistic regression analysis were performed to analyze the related risk factors of AKI in patients with PNS. Results A total of 328 patients with PNS were included, the incidence of AKI in PNS patients was 28.05%. Pearson correlation analysis showed that diabetes(r = 0.688), pulmonary infection (r = 0.614), albumin (r = 0.779), serum creatinine (r = 0.617), uric acid (r = 0.522), blood urea nitrogen (r = 0.616), renal tubular casts (r = 0.707) were correlated with AKI in PNS patients (all P < 0.05). Logistic regression analysis indicated that diabetes (OR2.908, 95%CI1.844 ~ 4.231), pulmonary infection(OR3.755, 95%CI2.831 ~ 4.987), albumin ≤ 24 g/L (OR1.923, 95%CI1.214 ~ 2.355), serum creatinine ≥ 90 μmol/L (OR2.517, 95%CI2.074 ~ 3.182), blood urea nitrogen ≥ 6.5 mmol/L (OR1.686, 95%CI1.208 ~ 2.123), uric acid ≥ 390 μmol/L (OR2.755, 95%CI2.131 ~ 3.371), renal tubular casts(OR1.796, 95%CI1.216 ~ 2.208) were the independently influencing factors of AKI in PNS patients (all P < 0.05). Conclusions AKI is common in PNS patients. Actively controlling diabetes and pulmonary infection, strengthening nutrition support and renal function monitoring are essential to reduce the occurrence of AKI in PNS patients.

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“…The chronic tubulointerstitial lesion is independent risk factor of ESRD [ 10 ]. The occurrence of acute kidney injury (AKI) was proved a predictor of ESRD [ 11 ]. However, the urinary biomarkers of renal tubular injury include urinary N-acetyl-β-glucosaminidase (NAG), Retinol binding protein (RBP), Kidney injury molecule-1 (KIM-1), and Neutrophil gelatinase-associated lipocalin (NGAL) were not routinely detected [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Non-diabetic urine glucose in idiopathic membranous nephropathy

Liu

Zuo

et al. 2022

Renal Failure

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This study aims to analyze the characteristics of idiopathic membranous nephropathy (iMN) with nondiabetic urine glucose during the follow-up. We retrospectively analyzed the data of 1313 patients who were diagnosed iMN. The prevalence of nondiabetic urine glucose during follow-up was 10.89%. There were significant differences between the patients with nondiabetic urine glucose and those without urine glucose in gender, hypertension ratio, proteinuria, N-acetyl-β-glucosaminidase, retinol binding protein, serum albumin, serum creatinine (Scr), cholesterol, triglyceride and positive anti-phospholipase A2 receptor antibody ratio, glomerular sclerosis ratio, acute and chronic tubular injury lesion at baseline. To exclude the influence of the baseline proteinuria and Scr, case control sampling of urine glucose negative patients was applied according to gender, baseline proteinuria and Scr. The proteinuria nonremission (NR) ratio was 45.83 versus 12.50% of the urine glucose positive group and case control group. Partial remission (PR) ratio of the two groups was 36.46 versus 23.96% and complete remission (CR) ratio was 19.79% versus 63.54%, respectively. Patients with urine glucose had higher risk of 50% estimated glomerular filtration rate (eGFR) reduction. Cox regression showed that urine glucose and baseline Scr were risk factors of 50% reduction of eGFR. Urine glucose remission ratio of the patients with proteinuria NR, PR, and CR was 13.33, 56.25, and 94.73% ( p < 0.005). Patients who got urine glucose remission also had better renal survival. In conclusion, non-diabetic urine glucose was closely related to proteinuria. It could be applied as a tubular injury marker to predict renal function.

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Acute kidney injury in idiopathic membranous nephropathy with nephrotic syndrome

Cited by 7 publications

References 36 publications

Prediction model of renal function recovery for primary membranous nephropathy with acute kidney injury

Prediction model of renal function recovery for primary membranous nephropathy with acute kidney injury

Acute kidney injury in patients with primary nephrotic syndrome: influencing factors and coping strategies

Non-diabetic urine glucose in idiopathic membranous nephropathy

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