Acute kidney injury in patients with chronic liver disease

Abstract

Acute kidney injury (AKI) is a frequent clinical event in patients with liver disease, compounding their prognosis. Furthermore, it is likely that the occurrence of AKI has a detrimental impact on the subsequent renal function and the long-term survival of these patients. Recently, some authors advocated the use of new diagnostic criteria for detecting acute kidney injury in patients with cirrhosis. These criteria are based on the rapidity and extent of the creatinine increase comparing to the basal creatinine and also on the kinetics of diuresis decrease. Although their validity in this population requires further studies to be clearly established, these new criteria could have two advantages: (1) to allow earlier diagnosis of AKI and, thus, hepatorenal syndrome for which earlier intervention could improve patients' survival; and (2) to promote more intensive monitoring of renal function in these patients with high risk of AKI. Finally, recent practice guidelines about the prevention and treatment of general AKI have been published which should be useful in optimising the management of AKI in cirrhotic patients.

Resolvin D1 and E1 alleviate the progress of hepatitis toward liver cancer in long-term concanavalin A-induced mice through inhibition of NF-κB activity

“…Liver disease is also referred to as hepatic disease. Liver disease is regarded as a major public health problem worldwide due to serious morbidity and mortality (2,4). Liver disease can be caused by inherited disorders such as cystic fibrosis or hemochromatosis, a condition that involves having too much iron in your body or Wilson's disease, a disorder in which the body to retains too much cupric ion (5).…”

Effect of Liver Cirrhosis on the Outcomes of Peritoneal Dialysis

“…However, exactly what type of dialysis is effective for patients with ESRD and LC is not well known. Additionally, there have been few studies on the clinical results of PD therapy in patients with LC and ESRD (19,20). A previous paper, published in 2002, showed that the outcome of PD was not worsened by the presence of LC (21), but the performance of PD, the level of education, and basic treatment for other comorbidities have improved over 15 years.…”

In-Hospital Mortality in Cirrhotic Patients with End-Stage Renal Disease Treated with Hemodialysis versus Peritoneal Dialysis: A Nationwide Study

“…There are few studies that report clinical results of longterm PD therapy in patients with cirrhosis and end-stage renal disease (ESRD) (5)(6)(7)(8). Most of these results are controversial because they resulted from a small number of cases.…”