Acute Kidney Injury in the Critically Ill Patient

Pakula, Andrea; Skinner, Ruby

doi:10.1177/0885066615575699

Cited by 45 publications

(38 citation statements)

References 53 publications

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“…1,2 The incidence of postoperative renal impairment (manifested by an increase in serum creatinine or urea) varies between 1% and 15%. 3,4 This can be associated with a mortality rate of up to 19%.…”

Section: Introductionmentioning

confidence: 99%

Predictors of acute kidney injury after coronary artery surgery in Jordanians

Ibrahim

Kherallah

AlWaqfi

et al. 2015

Asian Cardiovasc Thorac Ann

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Section: Introductionmentioning

confidence: 99%

Predictors of acute kidney injury after coronary artery surgery in Jordanians

Ibrahim

Kherallah

AlWaqfi

et al. 2015

Asian Cardiovasc Thorac Ann

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“…The AKI incidence rates were 130-150 per 10,000/year, particularly among older people [2]. It is the main reason for multiple organ insufficiency and death rate up to 80% [3,4]. All this indicates that the traditional treatment methods of acute renal failure using drugs and renal replacement therapy to be insufficient.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Apheresis in Acute Kidney Injury

Va¹,

Kovalev²,

Karchevsky³

et al. 2018

J Kidney

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Acute kidney injury is a serious complication of various inflammatory diseases of the abdominal and thoracic cavities, severe injuries and burns, eclampsia and sepsis, and a number of infectious diseases. Considering such a variety of etiologies there is a main pathogenesis feature, which is based on endoxemia with accumulation of a number of toxic products that cause disturbances in the vessels endothelium permeability with perivascular edema associated with decrease in the renal blood flow, glomerular filtration, tubular necrosis and oligo-anuria. The most common tactics of treatment is to perform kidney replacement therapy, mainly different methods of hemofiltration. However, not all toxic products are removed and the mortality rate remains quite high. The inclusion of hemosorption and plasmapheresis in the complex of therapeutic measures gives more favorable and stable results, showing a significant reduction of the mortality rate.

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“…Acute kidney injury (AKI) is a problem all over the world with different causes and manifestations. Severe adverse outcomes such as high morbidity, long hospital stays, high medical cost, a risk of long-term dialysis and even late mortality can occur as a result of misidentification or underestimation of this problem (Pakula and Skinner, 2015). Acute kidney injury diagnosis is based on an absolute or percentage elevation in the serum creatinine concentration over the baseline (Waikar and Bonventre, 2009).…”

Section: Introductionmentioning

confidence: 99%

Human kidney injury molecule-1 and interleukin-18 as predictive markers of nephrotoxicity in acute organophosphorus poisoned patients in Zagazig University hospitals

El-Sheikh¹,

Allam²

2018

J. Toxicol. Environ. Health Sci.

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Organophosphorus (OP) poisoning is a major common cause of mortality and morbidity in most countries. Some clinical cases developed renal injury after acute OP poisoning. The aim of our study is to evaluate the levels of kidney injury molecule-1(KIM-1) and interleukin-18(IL-18) in acute OP poisoned patients as early predictors of OP induced nephrotoxicity. Over a period of one year, the observational cross sectional study was conducted at the Poison Control Center, Zagazig University hospitals, Zagazig, Egypt. The study group consisted of 95 patients who fulfilled the inclusion criteria; the patients were categorized according to Peradeniya organophosphorus poisoning (POP) scale. The serum pseudocholine esterase enzyme (PChE), serum creatinine, urinary KIM-1 and IL-18 were assayed at 0, 12, 24 and 48 h after admission. There were progressive increases in the mean values of KIM-1 and IL-18 at different time intervals especially in severe poisoned patients compared to the increased levels of serum creatinine. The cutoff values of urinary KIM-1 and IL-18 that determined patients with potential AKI were 2.8 ng/ml creatinine (86.9% sensitivity, 94.6% specificity and 0.859% area under curve) and 59 pg/dl creatinine (90% sensitivity, 92% specificity and 0.946& area under curve), respectively. A positive correlation was observed between KIM-1 and IL-18 and serum creatinine. Moreover, KIM-1 is positively correlated with IL-18. Urinary KIM-1 and IL-18 may be considered as valid markers for prediction of acute kidney injury among acute OP poisoned patients.

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Acute Kidney Injury in the Critically Ill Patient

Cited by 45 publications

References 53 publications

Predictors of acute kidney injury after coronary artery surgery in Jordanians

Predictors of acute kidney injury after coronary artery surgery in Jordanians

Therapeutic Apheresis in Acute Kidney Injury

Human kidney injury molecule-1 and interleukin-18 as predictive markers of nephrotoxicity in acute organophosphorus poisoned patients in Zagazig University hospitals

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