Acute kidney injury in the ICU: from injury to recovery: reports from the 5th Paris International Conference

Abstract

The French Intensive Care Society organized its yearly Paris International Conference in intensive care on June 18–19, 2015. The main purpose of this meeting is to gather the best experts in the field in order to provide the highest quality update on a chosen topic. In 2015, the selected theme was: “Acute Renal Failure in the ICU: from injury to recovery.” The conference program covered multiple aspects of renal failure, including epidemiology, diagnosis, treatment and kidney support system, prognosis and recovery together with acute renal failure in specific settings. The present report provides a summary of every presentation including the key message and references and is structured in eight sections: (a) diagnosis and evaluation, (b) old and new diagnosis tools, (c) old and new treatments, (d) renal replacement therapy and management, (e) acute renal failure witness of other conditions, (f) prognosis and recovery, (g) extracorporeal epuration beyond the kidney, (h) the use of biomarkers in clinical practice http://www.srlf.org/5th-paris-international-conference-jeudi-18-et-vendredi-19-juin-2015/.

Major Adverse Kidney Events Are Associated with the Aquaporin 5 -1364A/C Promoter Polymorphism in Sepsis: A Prospective Validation Study

“…Acute kidney injury (AKI) is a detrimental condition in critically ill patients and independently associated with morbidity and mortality [1,2]. AKI, characterized by a rapid decline in renal function, usually occurs as a complication of other severe medical conditions, such as sepsis [3].…”

“…These findings confirm the important role of the AQP5 -1364A/C polymorphism as an independent prognostic factor in sepsis. Furthermore, we demonstrate a strong association between this AQP5 polymorphism and susceptibility for major adverse kidney events suggesting a promising characteristic in terms of precision medicine.Cells 2020, 9, 904 2 of 11 AKI and its sequelae still remain a challenge [7,8], and patients are stratified for distinct AKI phenotypes associated with either recovery or poor prognosis [1,8].However, although several clinical risk factors for the development of AKI have been identified, the pathogenesis and mechanisms of AKI itself remain poorly understood [9]. Genetic factors have been proposed to contribute to interindividual differences of susceptibility to and recovery from AKI relevantly [10].…”

“…Cells 2020, 9, 904 2 of 11 AKI and its sequelae still remain a challenge [7,8], and patients are stratified for distinct AKI phenotypes associated with either recovery or poor prognosis [1,8].…”

Continuous renal replacement therapy is associated with acute cardiac stunning in critically ill patients

“…Acute kidney injury (AKI) is a common complication of critical illness that is associated with high morbidity, mortality, and increased cost of care . Many critically ill patients that develop AKI will require renal replacement therapy (RRT), with those requiring it having mortality rates that exceed 50% .…”

“…Acute kidney injury (AKI) is a common complication of critical illness that is associated with high morbidity, mortality, and increased cost of care. [1][2][3] Many critically ill patients that develop AKI will require renal replacement therapy (RRT), with those requiring it having mortality rates that exceed 50%. 4 The mode of renal support in critically ill patients with AKI remains a matter of debate, with continuous therapies generally preferred in the sickest patients who are hypotensive or in circulatory shock that requires vasoactive agents.…”