2021
DOI: 10.3389/fphys.2021.744735
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Acute Kidney Injury Increase Risk of Left Ventricular Remodeling: A Cohort of 1,573 Patients

Abstract: Background: Acute kidney injury (AKI) is a common complication after coronary angiography (CAG) and associated with heart failure (HF). Left ventricular (LV) remodeling is a vital process in the progression of HF. However, few studies investigate the relationship between AKI and LV remodeling.Methods: We included consecutive patients undergoing CAG from January 2007 to December 2018 at Guangdong Provincial People’s Hospital (NCT04407936). AKI was defined as an absolute increase in serum creatinine (Scr) of ≥ 0… Show more

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Cited by 5 publications
(2 citation statements)
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“…Additionally, Domingo et al also found that renal insufficiency was a strong predictor of HF development among 2,763 women with CAD (23). Similarly, our previous study has shown that acute kidney injury could increase the risk of ventricular remodeling in patients undergoing CAG (24), which indicated that there was a close relationship between renal dysfunction and HF. Patients with CAD still have a risk for incident HFrEF even after PCI and optimal drug therapy (2).…”
Section: Discussionmentioning
confidence: 53%
“…Additionally, Domingo et al also found that renal insufficiency was a strong predictor of HF development among 2,763 women with CAD (23). Similarly, our previous study has shown that acute kidney injury could increase the risk of ventricular remodeling in patients undergoing CAG (24), which indicated that there was a close relationship between renal dysfunction and HF. Patients with CAD still have a risk for incident HFrEF even after PCI and optimal drug therapy (2).…”
Section: Discussionmentioning
confidence: 53%
“…More than a compensatory change, cardiac remodeling not only plays a formidable role in the progression of cardiac dysfunction to heart failure but also participates in the functional impairment of the kidney (7). Accumulating evidence demonstrates the remarkable correlation between cardiac remodeling and the development of chronic kidney disease (CKD); in turn, impaired renal function is more susceptible to developing into cardiac remodeling (8,9). As for patients undergoing operation, hemodynamic perturbation caused by decreased cardiac function can be attributed to postoperative acute kidney injury (10,11).…”
Section: Introductionmentioning
confidence: 99%