Acute kidney injury secondary to renal large B-cell lymphoma: role of early renal biopsy

Al-Salam, Suhail; Shaaban, A.; Alketbi, Maha; Haq, Naveed Ul; Abouchacra, Samra

doi:10.1007/s11255-010-9728-5

Cited by 24 publications

(25 citation statements)

References 13 publications

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“…AKI as a primary presenting feature of lymphomas remains a rare clinical entity and are only sparsely reported in the literature 4. Most renal lymphomas are due to infiltration from a secondary origin as was the case in our patient.…”

Section: Discussionsupporting

confidence: 56%

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Acute kidney injury as first presentation of lymphoma: the role of renal biopsy

Udberg

2013

BMJ Case Reports

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A 65-year-old man with an insidious history of being generally unwell with weight loss, a poor appetite and night sweats was transferred to a tertiary nephrology unit after being found to be in acute kidney injury (AKI). A renal biopsy was performed on the same day which revealed lymphomatous infiltration of the renal parenchyma. He required temporary haemodialysis as he was oliguric and was started on chemotherapy. His renal function improved to baseline 3 weeks after treatment. This case illustrates the uncommon presentation of direct lymphomatous infiltration as a cause of AKI and the integral role of renal biopsy in ascertaining the diagnosis.

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Section: Discussionsupporting

confidence: 56%

“…Our report adds weight to the importance of this investigation and hopefully is a reminder of its usefulness when investigating AKI of unknown causes with systemic symptoms 4 10–12…”

Section: Discussionmentioning

confidence: 78%

Acute kidney injury as first presentation of lymphoma: the role of renal biopsy

Udberg

2013

BMJ Case Reports

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“…However, a kidney biopsy remains the gold standard for the diagnosis of primary renal lymphoma (10).…”

Section: Introductionmentioning

confidence: 99%

Primary renal lymphoma: A case report and literature review

Chen

Fang

et al. 2016

Oncology Letters

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Abstract. Primary renal lymphoma (PRL) is a rare disease, with no more than 70 cases reported in the literature. The present study reports the case of a 70-year-old woman with PRL. The patient was asymptomatic, however, a mass on the right kidney was identified incidentally during routine physical examination. Computed tomography revealed a mass in the right kidney that was 3.6 cm in diameter. Subsequently, right nephrectomy was performed. The histological evaluation of the nephrectomy specimen showed diffuse large B-cell non-Hodgkin's lymphoma. The patient was treated with 6-8 cycles of a cyclophosphamide, epirubicin, vindesine and dexamethasone regimen. Follow-up examination performed after 2 months of treatment revealed no evidence of local recurrence. The present study also reviewed 49 cases of PRL that have been reported since 1989. It was found that a shorter survival time was experienced by patients with bilateral PRL (mean, 21 months) compared with unilateral PRL (mean, 68 months). A shorter survival time was also experienced by patients who were treated with chemotherapy only (mean, 15.8 months) compared with those who were treated with combination chemotherapy and surgery (mean, 49.4 months).

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“…Renal lymphoma can be either primary or associated with external lymphoma. [8][9] Primary renal lymphoma typically presents in age above 40, with flank pain, weakness, weight loss, hematuria, abdominal mass or renal failure. [4][5] Kidney does not have lymphoid tissue, 10 but repetitive injury to renal lymphatics due to chronic inflammation may cause malignant transformation to neoplasia of the lymphoid tissue.…”

Section: Discussionmentioning

confidence: 99%

“…MALT lymphomas can be treated with chemotherapy, surgical intervention or radiotherapy. 13 Chemotherapy is the foundation of treatment, especially for controlling systemic disease; 8 early proper treatment correlates with improved outcome. Patients with MALT lymphomas have a better prognosis compared with patients with a higher grade lymphomas.…”

Section: Discussionmentioning

confidence: 99%

A unique case of kidney’s collecting system MALT lymphoma

Asgari

Aval

Asgari

et al. 2014

CUAJ

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Low-grade B cell lymphomas of mucosa-associated lymphoid tissue (MALT lymphomas) are mostly seen in the gastrointestinal tract. MALT lymphomas involving kidney are extremely rare. We report on a case of MALT lymphomas of the kidney. A 74-yearold woman presented with an episode of gross hematuria and right flank pain. In renal sonography, we found a hypoecho lesion measuring 61 × 58 × 44 mm in the lower pole of right kidney. A computed tomography scan revealed an enlarged hypodense soft tissue measuring 62 × 42 × 37 mm within the pelvic brim of the right kidney, with extension to the proximal portion of the ipsilateral ureter and engulfed it. The patient underwent a right radical nephrectomy. The pathology specimen indicated a lymphoprolifrative disorder involving the kidney and ureter. To obtain a definitive diagnosis, we used an immunohistochemistry, which confirmed the diagnosis of a MALT lymphoma.

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Acute kidney injury secondary to renal large B-cell lymphoma: role of early renal biopsy

Cited by 24 publications

References 13 publications

Acute kidney injury as first presentation of lymphoma: the role of renal biopsy

Acute kidney injury as first presentation of lymphoma: the role of renal biopsy

Primary renal lymphoma: A case report and literature review

A unique case of kidney’s collecting system MALT lymphoma

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