Acute kidney injury with gross hematuria and IgA nephropathy after COVID-19 vaccination

Distinct glomerular disease association after vaccination with BNT162b2 and mRNA-1273: a VigiBase analysis

“…With the worldwide rollout of coronavirus disease 2019 (COVID-19) vaccines, numerous reports of de novo or relapsing glomerular diseases have been published recently ( 1) , 2) , 3) , 4) ). It has been stressed that associations between vaccination efforts and onset of disease do not prove causation, but administration of vaccines and induction of an immune response might trigger disease activity.…”

Gross haematuria after mRNA COVID‐19 vaccination in two patients with histological and clinical diagnosis of IgA nephropathy

“…Only two patients required steroid therapy for acute kidney injury. 1 , 2 Our first patient had earliest onset of gross haematuria within just 3 h. The transient strongly positive ANA indicates that the COVID‐19 vaccination may trigger more generalized immunological response beyond just stimulating IgA production. Reactivation of and new onset lupus nephritis after COVID‐19 vaccination with elevated ANA titre have also been reported recently, one after mRNA and the other after the AstraZeneca COVID‐19 vaccination.…”

An adolescent girl diagnosed with IgA nephropathy following the first dose of the COVID-19 vaccine

“…Even in adolescents, these mRNA vaccines have an acceptable safety profile and are highly effective against COVID-19 [4,5]. However, some cases of IgAN flare-up following vaccination against COVID-19 have been reported [1,[6][7][8][9][10][11]. In 13 cases reported previously, the timing of the appearance of gross hematuria after the first or second vaccine dose ranged from 1 to 5 days (median 1 day; interquartile range; 1-2 days) [1,[6][7][8][9][10][11].…”

“…However, some cases of IgAN flare-up following vaccination against COVID-19 have been reported [1,[6][7][8][9][10][11]. In 13 cases reported previously, the timing of the appearance of gross hematuria after the first or second vaccine dose ranged from 1 to 5 days (median 1 day; interquartile range; 1-2 days) [1,[6][7][8][9][10][11]. Our patient similarly presented with gross hematuria within 4 days of the first vaccine dose.…”

“…The causation between COVID-19 vaccination and IgAN flare-up remains unclear. There are several reports of IgAN patients presenting with gross hematuria following the second dose of the Pfizer or Moderna vaccines [1,[6][7][8][9][10][11]. Rahim et al suggested that a delayed-type hypersensitivity was associated with the IgAN flare [7].…”