Acute Leukæmia and Klinefelter's Syndrome

Kemp, N. H.; Stafford, Jane; Tanner, Rosemary

doi:10.1016/s0140-6736(61)92520-x

Cited by 23 publications

(2 citation statements)

References 4 publications

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“…The occurrence of myeloproliferative disorders has been already reported in patients with gonosomal abnormalities [5,6,16,17]. It is likely that the cells carrying chromosome abnormalities are more susceptible to the effects of oncogenic agents than cells with a nor mal chromosome complement [8].…”

Section: Discussionmentioning

confidence: 99%

Association of Multiple Haematological Disorders (Acute Myeloblastic Leukaemia, Paraproteinaemia, and Thalassaemia) in a 46, XX/46, XXqi Female

Castoldi¹,

Grusovin²,

Scapoli³

et al. 1971

Acta Haematol

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In a thalassaemic female carrying a 46, XX/46, XXqi mosaic, the occurrence of acute myeloblastic leukaemia was observed. Karyotype analysis of several bone marrow aspirates disclosed, besides both normal metaphases and metaphases containing the isochromosome, a line characterised by a supernumerary chromosome in the C group (C trisomy). A clonal proliferation of the leukaemic line from normal precursors was suggested since no cells carrying the isochromosome and the C trisomy together were found. In the course of the disease a remarkable plasma-cellular proliferation brought about a hyperglobulinaemia of monoclonal aspect (IgG, λ-type). Since the chromosomal analysis demonstrated that the presence of a C trisomy might also be present in the plasma cells, a close proliferative connection has been put forward for the stem cells differentiating along both the granulocytic and the plasmacytic line.

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Section: Discussionmentioning

confidence: 99%

Association of Multiple Haematological Disorders (Acute Myeloblastic Leukaemia, Paraproteinaemia, and Thalassaemia) in a 46, XX/46, XXqi Female

Castoldi¹,

Grusovin²,

Scapoli³

et al. 1971

Acta Haematol

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“…Leukaemia has recently been reported in cases of Klinefelter's syndrome (Kemp et al, 1961;Mamunes et al, 1961). While this situation may be clue to a random association, these observations brought up the possibility th at different loci are involved in normal leukopoesis and/or it would depend upon the relative frequency of any chromosome.…”

mentioning

confidence: 99%