1979
DOI: 10.1001/archinte.1979.03630410067021
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Acute Leukemia and Immunosuppressive Drug Use

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Cited by 110 publications
(6 citation statements)
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“…We found seven cases involving children [7,8,10,11,12,15,16]. One case of chronic myeloblastic leukemia is also reported [2].…”
Section: Review Of the Literaturementioning
confidence: 94%
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“…We found seven cases involving children [7,8,10,11,12,15,16]. One case of chronic myeloblastic leukemia is also reported [2].…”
Section: Review Of the Literaturementioning
confidence: 94%
“…Griinwald [7] reviewed 58 patients with acute leukemia after cytotoxic treatment of nonmalignant disease.…”
Section: Review Of the Literaturementioning
confidence: 99%
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“…However, the potential side effects with the use of 9 g of methylprednisolone mandated by this protocol as well as the potential risk of other serious side effects associated with the use of cytotoxic agents (such as bone marrow toxicity, severe infections, gonadal dysfunction) [17,18] combined with the long-term risk of malignancy associated with CYC [19,20,21,22] has left many physicians reluctant to use this regimen. For these reasons, the majority of the academic centers in the United States have considered CYC treatments too toxic and relegated the use of Ponticelli's protocol to rescue therapy in patients who have failed less toxic immunosuppressive therapies.…”
Section: Introductionmentioning
confidence: 99%