Acute Leukemia With Natural Killer Cells Antigens in Brazilian Children

Pombo‐de‐Oliveira, Maria S.; Campos, Maria Martha; Bossa, Yomayra Elena; Alencar, Dora Maria; Curvello, Cynthia; Agudelo, Diana Patrícia; Mendonça, Núbia; Pereira, Edinalva; Macedo-Silva, Maria Luiza

doi:10.1080/10428190310001624143

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…Differentiation of nonnasal NK-cell lymphomas occurring in the skin or soft tissue from extramedullary AML is particularly important for prognostic and therapeutic decisions. However, in acute lymphoblastic leukemia CD56 expression is relatively rare 134,[145][146][147] . CD56 is also expressed in a subset of T-cells, as well as 5-20% of peripheral T-cell lymphomas [148][149][150][151][152][153] .…”

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confidence: 99%

Leukemia and Lymphoma of Natural Killer Cells

Suzuki

2005

J Clin Exp Hematopathol

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Malignant hematolymphoid disorders arising from NK cells have become widely recognized over the past decade. The two forms of NK-cell malignancy, aggressive NK-cell leukemia (ANKL) and extranodal NK-cell lymphoma of nasal type (ENKL) are both characterized by the proliferation of tumor cells with an NK-cell like immunophenotype. ANKL usually presents with bone marrow tumor cells accompanied by circulating leukemic cells, and hepatosplenomegalay is a common clinical feature. ENKL most frequently affects the nasal or paranasal regions, with cutaneous involvement also being common. Approximately 70 percent of ENKL present with localized tumor cells, and follow an indolent clinical course, but, in advanced cases, tumors rapidly expand and are frequently fatal. Tumor cells from both ANKL and ENKL are surface CD3 − and CD56 + but differ in their expression of CD16. Epstein-Barr virus (EBV) is found in most cases of NK-cell leukemia/lymphoma, suggesting an oncogenic role, but patients may have biclonal or polyclonal populations of malignant cells based on differential EBV genome incorporation. NK-cell neoplasms are frequently resistant to chemotherapy due to p-glycoprotein expression and associated multidrug resistance. The prognoses of both localized and advanced stages of NK-cell malignancies are worse than most other lymphoid malignancies, but studies are currently underway to assess the safety and efficacy of novel chemoradiotherapy regimens for the treatment of these neoplasms.

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confidence: 99%

Leukemia and Lymphoma of Natural Killer Cells

Suzuki

2005

J Clin Exp Hematopathol

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“…They concluded that the patient had features of both myeloid/NK cell precursor acute leukemia and precursor NK lymphoblastic leukemia/ lymphoma, which suggested an NK-lineage leukemia entity forming a diagnostic continuum. Pombo-de-Oliveira et al [6] also reported a case without CD7 expression among nine cases of myeloid/NK cell precursor acute leukemia.…”

Section: Discussionmentioning

confidence: 91%

Pediatric myeloid/NK cell precursor lymphoma/leukemia expressing T/NK immunophenotype markers

et al. 2010

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Myeloid/NK cell precursor lymphoma/leukemia has been suggested to be of precursor NK origin. We report a 1-year-old boy with myeloid/NK cell precursor lymphoma/leukemia who presented with a skin nodule. Biopsy of the skin nodule specimen revealed CD45(+), CD56(+), myeloid antigen(+), CD7(-), CD3(-), CD19(-), CD34(-), CD4(-) by flow cytometry and myeloperoxidase (MPO)(+), TdT(+), cytoplasmic CD3(+) by immunohistochemistry. He received acute myeloid leukemia-oriented combination chemotherapy. Although his skin nodule disappeared, regrowth was observed; a biopsy was performed again, showing that the immunophenotype was CD56(+), myeloid antigen(+), HLA-DR(+), MPO(-), CD3(+) and TCRgammadelta(+). Being refractory to chemotherapy, he underwent stem cell transplantation from his father. However, he relapsed again and died from septic shock. Although myeloid/NK cell precursor acute leukemia is characterized by CD7(+), CD56(+), CD3(-), CD34(+) and myeloid antigen(+) phenotype, the blast cells of our patients lacked CD34 and CD7 expression while expressing myeloid antigens. Furthermore, CD94 1A transcripts were predominantly expressed rather than CD94 1B, implying their origin in immature NK cells. After acute myeloid leukemia-oriented combination chemotherapy, his blasts acquired stable CD3 expression and TCRgammadelta rearrangement at recurrence. The blast cells possessed features overlapping both myeloid/NK precursor acute leukemia and blastic NK/precursor acute lymphoma/leukemia. These observations suggest that two subclones originated from common precursors.

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“…Th e blast cells in a small proportion of ALL/LBL express CD56 and lack B-, T-, and myeloid-associated markers, do not show Ig and TCR gene rearrangements and are negative for EBV [79][80][81] . Th ey are CD45 dim and may express CD2, CD7, TdT, and/or CD16, and often lack cytoplasmic azurophilic granules.…”

Section: Nk-cell Lymphoblastic Leukemia/ Lymphomamentioning

confidence: 99%