Acute liver damage due to <i>Serenoa repens</i>: a case report

Lapi, Francesco; Gallo, Eugenia; Giocaliere, Elisa; Vietri, Michele; Baronti, Roberto; Pieraccini, Giuseppe; Tafi, Alessandro; Menniti‐Ippolito, Francesca; Mugelli, Alessandro; Firenzuoli, Fabio; Vannacci, Alfredo

doi:10.1111/j.1365-2125.2010.03618.x

Cited by 29 publications

(11 citation statements)

References 10 publications

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“…Consequently, published causality may be invalid for cases assessed by the Naranjo scale, the WHO scale or the ad hoc approach. Analysing publications of herbal hepatotoxicity , causality assessment was performed mostly with the ad hoc approach, and as shown with some examples rarely with the WHO scale , the Naranjo scale or the CIOMS scale …”

Section: Causality Attributionmentioning

confidence: 99%

Herbal hepatotoxicity: a tabular compilation of reported cases

Teschke

Wolff

Frenzel

et al. 2012

Liver International

116

113

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Section: Causality Attributionmentioning

confidence: 99%

Herbal hepatotoxicity: a tabular compilation of reported cases

Teschke

Wolff

Frenzel

et al. 2012

Liver International

116

113

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“…Indeed, there are a handful of case reports implicating SP in a disparate set of adverse events including hepatotoxicity 19 , coagulopathy 20 , pancreatitis 2122 , and intraoperative floppy-iris syndrome 23 . However, the causal relationship between the use of SP and each of these adverse events is not firmly established for most of these, as these reports are complicated by concomitant use of other drugs or supplements, absence of re-challenge, and missing information about temporal relationships.…”

Section: Discussionmentioning

confidence: 99%

Safety and Toxicity of Saw Palmetto in the CAMUS Trial

et al. 2013

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Purpose Extracts of the saw palmetto berry are used by many men in the U.S. as self-treatment for lower urinary tract symptoms due to benign prostatic hyperplasia. While the most recent data from double-blind clinical trials do not support efficacy superior to that of placebo, there are few data on the toxicity of saw palmetto. Materials and Methods 369 patients were randomized in the Complementary and Alternative Medicine for Urological Symptoms (CAMUS) trial; 357 participants are included in this modified intention-to-treat analysis. Participants were randomized to 320mg, 640mg, and 960mg daily of an ethanolic saw palmetto extract or an identical-appearing placebo, in an escalating manner at 6-month intervals, for a total of 18 months follow-up. Adverse-event assessments, vital signs, and blood and urine laboratory tests were obtained at regular intervals. Results There were no statistically significant differences between groups in rates of serious or non-serious adverse events, changes in vital signs, digital prostate exam findings, or study withdrawal rates. Overall, there were no significant inter-group differences in the occurrence of laboratory-test abnormalities; differences in individual laboratory tests were uncommon and small in magnitude. No evidence of significant dose-response phenomena were identified. Conclusions The saw palmetto extract used in the CAMUS trial showed no evidence of toxicity at doses up to three times the usual clinical dose over a period of 18 months.

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“…Da heute placebokontrollierte Studien vorliegen, spielen anekdotische Einzelfallberichte [5,21] für die Sicherheitsbewertung kaum mehr eine Rolle. In der Regel sind die Präparate besser verträglich als die medikamentösen Alternativen aus den Klassen der α1Adreno zep tor antagonisten (bspw.…”

Section: Leitlinie Bpsunclassified

Die Sägepalme

Niedenthal¹

2017

Z Phytother

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ZusammenfassungVon den nordamerikanischen Ureinwohnern wurde die Sägepalme (Serenoa repens (W. Bartram) Small) vielfältig genutzt, eine medizinische Verwendung lässt sich aber nicht sicher nachweisen. Als Arzneipflanze hatte die Sägepalme eine erste Blüte im späten 19. und frühen 20. Jahrhundert, als verschiedene Zubereitungen in der Pflanzenheilkunde und der Homöopathie beliebt waren. Neue wissenschaftliche Impulse kamen gegen Ende des 20. Jahrhunderts aus Europa, wo Sägepalmenfrüchte heute zur symptomatischen Behandlung der benignen Prostatahyperplasie (BPH) anerkannt sind. Daneben werden auch topische Anwendungen erforscht.

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Acute liver damage due to Serenoa repens: a case report

Cited by 29 publications

References 10 publications

Herbal hepatotoxicity: a tabular compilation of reported cases

Herbal hepatotoxicity: a tabular compilation of reported cases

Safety and Toxicity of Saw Palmetto in the CAMUS Trial

Die Sägepalme

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