Acute Liver Dysfunction in the Course of Norovirus Gastroenteritis

Nakajima, Hitoshi; Watanabe, Tomofumi; Miyazaki, Takanori; Takeuchi, Mamoru; Honda, Yoshihiro; Shimada, N.; Nakanishi, Kimio; Urita, Yoshihisa; Sugimoto, Masanao

doi:10.1159/000336202

Cited by 8 publications

(3 citation statements)

References 12 publications

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“…While self-limiting gastrointestinal infections are the norm, more severe intestinal pathologies such as necrotising enterocolitis in neonates [ 119 , 120 ], post-infectious irritable bowel syndrome [ 121 ], and exacerbation of inflammatory bowel disease [ 122 ] have been described. Atypical extraintestinal pathologies such as seizures in young children [ 123 , 124 , 125 ], encephalopathy [ 126 ], and acute liver dysfunction [ 127 , 128 ] have also been reported in association with norovirus infections. Norovirus RNA has been detected in sera [ 129 ] and cerebrospinal fluids [ 126 ] of infected individuals, suggesting possible spread to peripheral tissues.…”

Section: Clinical Aspects Of Norovirus Infectionmentioning

confidence: 99%

Noroviruses—The State of the Art, Nearly Fifty Years after Their Initial Discovery

Ludwig‐Begall

Mauroy

Thiry

2021

Viruses

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Human noroviruses are recognised as the major global cause of viral gastroenteritis. Here, we provide an overview of notable advances in norovirus research and provide a short recap of the novel model systems to which much of the recent progress is owed. Significant advances include an updated classification system, the description of alternative virus-like protein morphologies and capsid dynamics, and the further elucidation of the functions and roles of various viral proteins. Important milestones include new insights into cell tropism, host and microbial attachment factors and receptors, interactions with the cellular translational apparatus, and viral egress from cells. Noroviruses have been detected in previously unrecognised hosts and detection itself is facilitated by improved analytical techniques. New potential transmission routes and/or viral reservoirs have been proposed. Recent in vivo and in vitro findings have added to the understanding of host immunity in response to norovirus infection, and vaccine development has progressed to preclinical and even clinical trial testing. Ongoing development of therapeutics includes promising direct-acting small molecules and host-factor drugs.

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Section: Clinical Aspects Of Norovirus Infectionmentioning

confidence: 99%

Noroviruses—The State of the Art, Nearly Fifty Years after Their Initial Discovery

Ludwig‐Begall

Mauroy

Thiry

2021

Viruses

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“…Patients with rotavirus induced AGE have shown significantly higher AST levels than those inflicted with norovirus infection; however, ALT level was not significantly different between these two groups (18). These observations, and also occasional case reports of liver injury induced by AGE-associated viral strains (19,20), indicate a role for the viral etiology on liver function during acute AGE.…”

Section: Discussionmentioning

confidence: 80%

A Survey on the Fluctuations of Liver Enzymes in Severely Dehydrated Children with Acute Gastroenteritis

et al. 2019

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Background: Acute gastroenteritis (AGE) is a potential life-threatening condition in young children. Objectives: Our aim was to assess hepatic enzymes levels in children with AGE and severe dehydration (> 10%). Methods: We enrolled 138 children with AGE admitted to the Amir-Al-Momenin Hospital of Zabol city in 2016. Children with severe dehydration (> 10%), according to the Vesikari score, were included. Complete blood count, selected inflammatory markers, and hepatic enzymes were investigated.Results: Males and females comprised 89 (64.5%) and 49 (35.5%) of the cases, respectively. The mean age was 3 ± 2.7 years old. Concomitant aspartate aminotransferase (AST) and alanine aminotransferase (ALT) elevation and isolated AST elevation were observed in 22 (15.9%) and 60 (43.5%) of the patients, respectively. Normal AST and ALT levels were observed in 56 (40.6%) of the patients. The AST level significantly correlated with age (r = -0.230, P = 0.007) and platelet count (r = 0.184, P =0.03). Significant correlations were also detected between ALT level and age (r = -0.230, P = 0.007), ESR (r = -0.240, P = 0.03), and K + level (r = 0.244, P = 0.03). Conclusions: Our results highlighted relatively high frequency of elevated liver enzymes in severely dehydrated children with AGE.

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“…The virus is sometimes thought to lead to whole-body infection. Previous case report showed a 48-year-old female with norovirus gastroenteritis underwent acute liver dysfunction [2]. And the other case report showed the liver damage caused by rotavirus infection in a child [3].…”

Section: Introductionmentioning

confidence: 99%

Liver dysfunction in norovirus gastroenteritis in a child with cerebral palsy: A case report

2021

J Clin Images Med Case Rep

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Norovirus is the common cause of gastroenteritis in humans. There is no report of liver dysfunction in children caused by norovirus infection. Baclofen has been used mainly to treat spasticity in children with cerebral palsy. Hepatotoxicity of baclofen has not been previously described in children.This report describes the case of acute liver dysfunction in the course of norovirus gastroenteritis in a child with cerebral palsy (CP) on baclofen. A 7-year 7 month-old child who diagnosed spastic quadriplegic cerebral palsy showed mild fever and diarrhea. He started taking baclofen a week before the symptom started. His illness was diagnosed as norovirus gastroenteritis, but liver dysfunction accompanied this gastroenteritis (AST/ALT 589/401 (IU/L)). He recovered completely within 2 weeks without any damage left. When a child with cerebral palsy gets norovirus enteritis while taking baclofen, it would be necessary to close monitoring for liver failure. Keywords: norovirus; baclofen; cerebral palsy; liver dysfunction.

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Acute Liver Dysfunction in the Course of Norovirus Gastroenteritis

Cited by 8 publications

References 12 publications

Noroviruses—The State of the Art, Nearly Fifty Years after Their Initial Discovery

Noroviruses—The State of the Art, Nearly Fifty Years after Their Initial Discovery

A Survey on the Fluctuations of Liver Enzymes in Severely Dehydrated Children with Acute Gastroenteritis

Liver dysfunction in norovirus gastroenteritis in a child with cerebral palsy: A case report

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