2012
DOI: 10.1155/2012/487480
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Acute Liver Failure Caused byAmanita phalloidesPoisoning

Abstract: Mushroom poisoning is a relatively rare cause of acute liver failure (ALF). The present paper analyzes the pathogenesis, clinical features, prognostic indicators, and therapeutic strategies of ALF secondary to ingestion of Amanita phalloides, which represents the most common and deadly cause of mushroom poisoning. Liver damage from Amanita phalloides is related to the amanitins, powerful toxins that inhibit RNA polymerase II resulting in a deficient protein synthesis and cell necrosis. After an asymptomatic la… Show more

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Cited by 111 publications
(143 citation statements)
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“…This section focuses on amatoxin. Amatoxin-containing mushrooms cause the vast majority of fatalities from mycetism [6,9,29,34,38,[83][84][85]. A. phalloides (Death Cap), A. bisporigera, A. rubescens, A. ocreata, A. verna, and Amanita virosa (the last three are referred to as Death Angels and Destroying Angels; however, A. phalloides is also sometimes referred to as Death Angel and A. verna is sometimes referred to as White Death Cap), A. fuliginea, A. subjunquillea, A. exitialis, A. suballiacea, A. tenuifolia, A. hygroscopica as well as some Galerina and Lepiota (e.g., L. brunneoincarnata and L. helveola) species contain amatoxin.…”
Section: Hepatotoxinsmentioning
confidence: 99%
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“…This section focuses on amatoxin. Amatoxin-containing mushrooms cause the vast majority of fatalities from mycetism [6,9,29,34,38,[83][84][85]. A. phalloides (Death Cap), A. bisporigera, A. rubescens, A. ocreata, A. verna, and Amanita virosa (the last three are referred to as Death Angels and Destroying Angels; however, A. phalloides is also sometimes referred to as Death Angel and A. verna is sometimes referred to as White Death Cap), A. fuliginea, A. subjunquillea, A. exitialis, A. suballiacea, A. tenuifolia, A. hygroscopica as well as some Galerina and Lepiota (e.g., L. brunneoincarnata and L. helveola) species contain amatoxin.…”
Section: Hepatotoxinsmentioning
confidence: 99%
“…A. phalloides (Death Cap), A. bisporigera, A. rubescens, A. ocreata, A. verna, and Amanita virosa (the last three are referred to as Death Angels and Destroying Angels; however, A. phalloides is also sometimes referred to as Death Angel and A. verna is sometimes referred to as White Death Cap), A. fuliginea, A. subjunquillea, A. exitialis, A. suballiacea, A. tenuifolia, A. hygroscopica as well as some Galerina and Lepiota (e.g., L. brunneoincarnata and L. helveola) species contain amatoxin. As little as 0.1 mg amatoxin/kg body weight may be lethal in adults [36,37,[84][85][86][87][88].…”
Section: Hepatotoxinsmentioning
confidence: 99%
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