Acute Liver Failure from Herpes Simplex Virus in an Immunocompetent Patient Due to Direct Inoculation of the Peritoneum

Chaudhary, Dhruv; Ahmed, Shifat; Liu, Nanlong; Marsano-Obando, Luis S.

doi:10.14309/crj.2017.23

Cited by 8 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, Herpes viruses such as Epstein–Barr virus (EBV), Cytomegalo virus (CMV), Adenovirus and Varicella zoster virus (VZV) also induce hepatic injury ( Lalazar and Ilan, 2014 ). Herpes simplex virus (HSV) induced hepatitis is a rare cause of acute liver failure ( Chaudhary et al, 2017 ).…”

Section: Antiviral Effect Of Zinc On Hepatitis Virusesmentioning

confidence: 99%

Antiviral activity of zinc against hepatitis viruses: current status and future prospects

Kumar,

Ansari,

Narayanan

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

Viral hepatitis is a major public health concern globally. World health organization aims at eliminating viral hepatitis as a public health threat by 2030. Among the hepatitis causing viruses, hepatitis B and C are primarily transmitted via contaminated blood. Hepatitis A and E, which gets transmitted primarily via the feco-oral route, are the leading cause of acute viral hepatitis. Although vaccines are available against some of these viruses, new cases continue to be reported. There is an urgent need to devise a potent yet economical antiviral strategy against the hepatitis-causing viruses (denoted as hepatitis viruses) for achieving global elimination of viral hepatitis. Although zinc was known to mankind for a long time (since before Christ era), it was identified as an element in 1746 and its importance for human health was discovered in 1963 by the pioneering work of Dr. Ananda S. Prasad. A series of follow up studies involving zinc supplementation as a therapy demonstrated zinc as an essential element for humans, leading to establishment of a recommended dietary allowance (RDA) of 15 milligram zinc [United States RDA for zinc]. Being an essential component of many cellular enzymes and transcription factors, zinc is vital for growth and homeostasis of most living organisms, including human. Importantly, several studies indicate potent antiviral activity of zinc. Multiple studies have demonstrated antiviral activity of zinc against viruses that cause hepatitis. This article provides a comprehensive overview of the findings on antiviral activity of zinc against hepatitis viruses, discusses the mechanisms underlying the antiviral properties of zinc and summarizes the prospects of harnessing the therapeutic benefit of zinc supplementation therapy in reducing the disease burden due to viral hepatitis.

show abstract

Section: Antiviral Effect Of Zinc On Hepatitis Virusesmentioning

confidence: 99%

Antiviral activity of zinc against hepatitis viruses: current status and future prospects

Kumar,

Ansari,

Narayanan

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Діарея серед наших пацієнтів була другим за частотою порушенням функції ШКТ. За даними опублікованих досліджень, діарея серед пацієнтів з тяжким перебігом гострих захворювань зустрічається в 11-78 % випадків [17][18][19][20][21] [27][28][29]. За опублікованими даними, у пацієнтів з вітряною віспою зростання АЛТ виявлялось у 50,9 %, підвищення білірубінуу 20 % [27], підвищення АЛТ спостерігалось у 14 % хворих з HSV-інфекцією, при EBV-інфекції помірне зростання АЛТ та ЛДГ -у 90 % випадків, підвищення ЛФ -у 60 % і білірубіну -у 45 % [30].…”

Section: обговоренняunclassified

Гастроінтестинальні Симптоми При Гострих Нейроінфекціях У Дітей

Markov

Kramarov

2021

View full text Add to dashboard Cite

²íôåêö³¿ â ä³òåé / Infections in Children ® Вступ Гострі нейроінфекції у дітей зазвичай мають тяжкий перебіг та характеризуються високим рівнем ускладнень і несприятливих наслідків. При тяжких формах інфекційних захворювань окрім локального запалення можуть відбуватися вторинні ураження інших органів і систем [1]. Одними з таких ускладнень є ураження органів шлунково-кишкового тракту (ШКТ). Воно може бути пов'язано як з ушкодженням епітелію, нейроендокринної регуляції кишечника, так і з порушенням кишкової мікробіоти [2]. Контроль функціонального стану та рання діагностика уражень ШКТ і печінки під час гострих захворювань на сьогодні залишаються проблематичними, оскільки для шлунково-кишкового тракту досі відсутні загальновизнані методи лабораторного контролю, а стандартні тести ураження гепатоцитів

show abstract

“…These two agents inhibit the catalytic unit of viral DNA polymerase and do not require activation by thymidine kinase [21]. Chaudhary et al reported one case of HSV hepatitis that showed no improvement with acyclovir, but when foscarnet was added the patient’s mental status improved and she was ultimately discharged home with no need for liver transplantation [22]. Other important questions to consider with regards to treatment are the optimal route of administration (intravenous vs oral) and the subsequent duration of therapy.…”

Section: Reviewmentioning

confidence: 99%

Herpes Simplex Virus Hepatitis: A Brief Review of an Oft-overlooked Pathology

Then

Gayam

Are

et al. 2019

Cureus

View full text Add to dashboard Cite

Herpes simplex virus (HSV) is a rarely reported cause of viral hepatitis. Aggressive in nature, most cases of HSV hepatitis rapidly progress to fulminant hepatic failure. Present day, its pathogenesis is yet to be elucidated, but its complications and associated high mortality rate are clear. Clinically, its symptoms mimic those of other causes of acute hepatic failure thus making the diagnosis of HSV hepatitis a precarious task. Although treatment in the form of acyclovir is readily available, most cases have a poor prognosis due to late initiation of therapy. This makes the early identification of HSV essential in improving outcomes and potentially preventing mortality.

show abstract

Acute Liver Failure from Herpes Simplex Virus in an Immunocompetent Patient Due to Direct Inoculation of the Peritoneum

Cited by 8 publications

References 17 publications

Antiviral activity of zinc against hepatitis viruses: current status and future prospects

Antiviral activity of zinc against hepatitis viruses: current status and future prospects

Гастроінтестинальні Симптоми При Гострих Нейроінфекціях У Дітей

Herpes Simplex Virus Hepatitis: A Brief Review of an Oft-overlooked Pathology

Contact Info

Product

Resources

About