Acute liver failure secondary to opportunistic viral infection in adult solid organ transplant recipients

Claridge, Lee C; Dobson, Colin; Kanji, Hemali; Neil, Desley; Timms, Judith; Holt, Andrew

doi:10.1093/qjmed/hcr117

Cited by 6 publications

(1 citation statement)

References 15 publications

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“…We report a unique case of acute liver failure and rhabdomyolysis in a young healthy collegiate male athlete presumed to be secondary to adenovirus infection. Though there have been previous case reports of adenovirus leading to acute liver failure in toddlers [ 2 , 5 ] and in the elderly immunocompromised population [ 3 , 4 , 12 ], this is the first reported case of adenovirus associated liver failure in a healthy, young adult. Although rhabdomyolysis has been linked to elevated liver aminotransferases with peak ALT/AST levels around 600 U/L [ 13 , 14 ], it has never been shown to lead to acute liver failure with profound elevations in liver aminotransferases, INR and splenomegaly as in this case.…”

Section: Discussionmentioning

confidence: 93%

Adenovirus Infection and Rhabdomyolysis as a Cause of Acute Liver Failure in a Healthy Collegiate Football Athlete: A Case Report and Proposed Return to Play Protocol for Rhabdomyolysis

Hwang

Matheson

Baine

2021

Cureus

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Adenovirus is a common cause of upper respiratory and gastrointestinal tract infections. Though cases of significant organ failure and death have been reported in young children and immunocompromised individuals, adenovirus infections in healthy individuals are typically self-limiting without significant morbidity or mortality. Exertional rhabdomyolysis is a pathologic condition resulting from repetitive, excessive, or prolonged exercise, often in a hot environment, leading to acute muscle injury, renal injury and, rarely, death. We report a case of adenovirus infection leading to acute liver failure complicated by rhabdomyolysis in a collegiate football player presenting with nausea, vomiting, and diarrhea. We propose a protocol to safely guide the return to play progression for patients with complicated exertional rhabdomyolysis.

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