Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS)

Pechulis, Rita; Satti, Aditi; Wang, Ping; Qin, Xu‐Jie; Criner, Gerard J.

doi:10.1007/978-0-387-77452-7_16

Cited by 4 publications

(4 citation statements)

References 34 publications

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“…It was reported that Alprostadil exerts its effect through protecting the pulmonary vascular endothelial cells [ 8 – 10 ]. However, the OA-induced ARDS model features injury to pulmonary vascular endothelial cells [ 29 , 30 ]. Thus, in the present study, the OA-induced ARDS model was used to investigate the role of Alprostadil in ARDS.…”

Section: Discussionmentioning

confidence: 99%

“…When administered intravenously, OA induces acute diffuse lung injury, which is similar to the initial phase of ALI and ARDS in humans [ 28 ]. Following OA administration, pulmonary vascular endothelial cell injury, local hemorrhage, edema, and inflammation can occur [ 29 , 30 ]. Thus, use of OA to mimic ARDS in animal models is well established.…”

Section: Introductionmentioning

confidence: 99%

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Protective Effect and Mechanism of Alprostadil in Acute Respiratory Distress Syndrome Induced by Oleic Acid in Rats

Yan

Choi

et al. 2018

Med Sci Monit

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BackgroundThis study investigated the role and mechanism of alprostadil in acute respiratory distress syndrome (ARDS) induced by oleic acid (OA) in rats.Material/MethodsSprague-Dawley rats were randomly divided into control, OA model, and OA + Alprostadil (2.5, 5, and 10 μg/kg, respectively) groups. The ARDS model was induced by femoral vein injection of OA, and alprostadil was administrated immediately. Lung injury was evaluated by lung wet-dry weight ratio (W/D) and histological analyses. Expressions of ACE, inflammatory mediators, apoptotic-related proteins, and proteins in the MAPKs and NF-κB signaling pathways were determined by Western blot or immunohistochemical staining.ResultsCompared with the control group, the OA model group had significantly increased W/D, lung injury score, and collagen deposition at 3 h after OA injection. However, alprostadil (10 μg/kg) treatment significantly reduced OA-induced elevation of these indicators. Additionally, OA-induced expression of TNF-α and IL-1β were suppressed by alprostadil. The OA-induced activation of nuclear factor (NF) κB p65 was also reduced by alprostadil. Furthermore, we found that Alprostadil had an inhibitory effect on the phosphorylation of JNK, ERK1/2, and p38 MAPKs. Alprostadil inhibited Bax but increased Bcl-2, indicating a suppressive role in apoptosis. Remarkably increased expression of ACE in the OA model group was observed, which was decreased by alprostadil.ConclusionsAlprostadil has a protective effect on ARDS induced by OA in rats, possibly through inhibiting apoptosis, suppressing the activation of MAPKs and NF-κB signaling pathways, and decreasing ACE protein expression. Therefore, the use of alprostadil in clinical ARDS treatment is promising.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protective Effect and Mechanism of Alprostadil in Acute Respiratory Distress Syndrome Induced by Oleic Acid in Rats

Yan

Choi

et al. 2018

Med Sci Monit

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“…ALI in both human and animal models is associated with pulmonary overexpression of iNOS and enhanced NO production [12,21] and inhibitors of iNOS may be potential therapeutic agents for clinical application in patients with ALI/ARDS.…”

Section: Resultsmentioning

confidence: 99%

“…ALI is characterized by the development of hypoxemia, damage to the alveolar capillary membrane barrier, pulmonary edema, and the resultant respiratory failure [12,21]. Thus, considering that FBP reduced various inflammatory parameters in several animal and in vitro models, the purpose of this study was to assess the role of FBP in Zymosan-induced ALI in mice.…”

Section: Introductionmentioning

confidence: 99%

Fructose-1,6-bisphosphate Protects against Zymosan-induced Acute Lung Injury in Mice

et al. 2012

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It has been previously showed that fructose-1,6-bisphosphate (FBP) has anti-inflammatory and immunomodulatory effects on several experimental inflammation models. However, the effects and mechanism of FBP on Zymosan-induced acute lung injury (ALI) in mice had not been tested. In this study, our aim was to assess the anti-inflammatory activities of FBP on Zymosan-induced ALI. We found that in vivo treatment with FBP (500 mg/kg i.p.) markedly decreased the nitric oxide (NO) levels in the lungs and significantly reduced bronchoalveolar lavage fluid total cell and neutrophil counts and protein exudation after Zymosan challenge. Furthermore, FBP inhibited inducible nitric oxide synthase (iNOS) activities in RAW macrophages. Meanwhile, FBP did not inhibit the cyclooxigenase 2, interleukin-6, and nuclear factor kappa B transcription. Taken together, these results suggest that FBP shows anti-inflammatory effects through inhibiting lung edema, NO, and iNOS activities.

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The impact of policies to restrict the use of plasma containing products and apheresis platelets from female donors to mitigate transfusion related acute lung injury (TRALI) in Brazil

Blatyta

Custer

Liu

et al. 2013

Transfusion and Apheresis Science

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Background and Objectives Although the incidence of TRALI is unknown in Brazil, some blood centers have adopted strategies to prevent TRALI. We evaluated the impact of three policies to mitigate TRALI on the supply of blood products: to divert the production of whole blood-derived plasma from female donors; to defer all female donors from apheresis platelet collections, and to defer only multiparous female donors from apheresis platelet collections. Materials and Methods Data from allogeneic whole blood and apheresis platelet donations from April 2008 to December 2009 were collected in three Brazilian blood centers and the impact of the aforementioned strategies was evaluated. Results Of 544,814 allogeneic blood donations, 30.8% of whole blood plasma and 24.1% of apheresis platelet donations would be reduced if only male donor plasma was issued for transfusion and all female donors were deferred from apheresis donation, respectively. If only multiparous donors were deferred from apheresis donation, there would be a 5% decrease of all apheresis platelet collections. Conclusion Restricting the use of whole blood derived plasma to male-only donors and deferring all female apheresis platelet donors would impact two out of three Brazilian blood centers. A deferral policy on multiparous apheresis platelet donors may be acceptable as a temporary measure, but may cause more stress on a system that is already working at its limit.

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Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS)

Cited by 4 publications

References 34 publications

Protective Effect and Mechanism of Alprostadil in Acute Respiratory Distress Syndrome Induced by Oleic Acid in Rats

Protective Effect and Mechanism of Alprostadil in Acute Respiratory Distress Syndrome Induced by Oleic Acid in Rats

Fructose-1,6-bisphosphate Protects against Zymosan-induced Acute Lung Injury in Mice

The impact of policies to restrict the use of plasma containing products and apheresis platelets from female donors to mitigate transfusion related acute lung injury (TRALI) in Brazil

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