Acute lung injury in patients with subarachnoid hemorrhage: Incidence, risk factors, and outcome

Kahn, Jeremy M.; Caldwell, Ellen; Deem, Steven; Newell, David W.; Heckbert, Susan R.; Rubenfeld, Gordon D.

doi:10.1097/01.ccm.0000194540.44020.8e

Cited by 186 publications

(173 citation statements)

References 28 publications

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“…Some reports have demonstrated that a significant part of patients with acute brain injury develop pulmonary complications. 22,23 Three major causes of pulmonary complications are recognized in brain injured patients: neurogenic pulmonary edema, ventilation-perfusion mismatch, and structural parenchymal abnormalities. 24 In animals, severe brain injury can trigger sympathetic activation that increases pulmonary vascular resistance, resulting in pulmonary edema.…”

Section: Respiratory Failure and Biomarkersmentioning

confidence: 99%

Lack of association of S100β and neuron-specific enolase with mortality in critically ill patients

Macedo

Tomasi

Giombelli

et al. 2013

Rev. Bras. Psiquiatr.

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Objective: To evaluate the relationship between brain damage biomarkers and mortality in the intensive care unit (ICU). Methods: The sample comprised 70 patients admitted to an ICU. Blood samples were collected from all patients on ICU admission, and levels of S100b and neuron-specific enolase (NSE) were determined by ELISA. Results: Acute Physiologic and Chronic Health Evaluation (APACHE II) score was associated with mortality, but NSE and S100b were not associated with this outcome. In contrast, S100b levels were significantly higher in delirious and non-delirious patients who required mechanical ventilation during ICU stay. Conclusion: Levels of brain biomarkers at the time of ICU admission did not predict mortality in critically ill patients.

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Section: Respiratory Failure and Biomarkersmentioning

confidence: 99%

Lack of association of S100β and neuron-specific enolase with mortality in critically ill patients

Macedo

Tomasi

Giombelli

et al. 2013

Rev. Bras. Psiquiatr.

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“…In previous reports, ARDS occurs in up to 20-38% of cases of subarachnoid haemorrhage [13][14][15], traumatic brain injury [1,16] and spontaneous intracerebral haemorrhage [4,5,17,18], and 35% reported in a mixed cohort of neurologically ill patients [19]. Variability in ARDS incidence may reflect differences in study populations and in diagnosis approach, variable use of consensus approach.…”

Section: Discussionmentioning

confidence: 99%

“…ARDS was also associated with a significant increase in mortality, and it prolonged the duration of mechanical ventilation and the length of ICU stay. Similarly, in previous reports, ARDS has been identified as a major contributor to the morbidity and mortality of patients with brain injuries [2,3,5,15,17,18,30]. ARDS also worsens longterm neurologic outcome [1,2,3,32], and is associated with longer ICU and hospital length of stay [5,29].…”

Section: Discussionmentioning

confidence: 99%

Association between ventilatory settings and development of acute respiratory distress syndrome in mechanically ventilated patients due to brain injury

Tejerina

Pelosi

Muriel

et al. 2017

Journal of Critical Care

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a b s t r a c t a r t i c l e i n f oPurpose: In neurologically critically ill patients with mechanical ventilation (MV), the development of acute respiratory distress syndrome (ARDS) is a major contributor to morbidity and mortality, but the role of ventilatory management has been scarcely evaluated. We evaluate the association of tidal volume, level of PEEP and driving pressure with the development of ARDS in a population of patients with brain injury. Materials and methods: We performed a secondary analysis of a prospective, observational study on mechanical ventilation. Results: We included 986 patients mechanically ventilated due to an acute brain injury (hemorrhagic stroke, ischemic stroke or brain trauma). Incidence of ARDS in this cohort was 3%. Multivariate analysis suggested that driving pressure could be associated with the development of ARDS (odds ratio for unit increment of driving For personal use only. No other uses without permission. Copyright ©2017. Elsevier Inc. All rights reserved. pressure 1.12; confidence interval for 95%: 1.01 to 1.23) whereas we did not observe association for tidal volume (in ml per kg of predicted body weight) or level of PEEP. ARDS was associated with an increase in mortality, longer duration of mechanical ventilation, and longer ICU length of stay. Conclusions: In a cohort of brain-injured patients the development of ARDS was not common. Driving pressure was associated with the development of this disease.

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“…Actualmente las complicaciones médicas no neurológicas siguen provocando morbilidad, mortalidad y aumento de estancias en UCI y hospitalarias y generando costes añadidos [75][76][77] . Junto a la presencia frecuente de fiebre, anemia e hiperglucemia son las complicaciones respiratorias 78 , cardiológicas 79 y los trastornos electrolíticos las alteraciones más frecuen- …”

Section: Complicaciones Sistémicasunclassified

Manejo general en Cuidados Intensivos del paciente con hemorragia subaracnoidea espontánea

2008

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Acute lung injury in patients with subarachnoid hemorrhage: Incidence, risk factors, and outcome

Cited by 186 publications

References 28 publications

Lack of association of S100β and neuron-specific enolase with mortality in critically ill patients

Lack of association of S100β and neuron-specific enolase with mortality in critically ill patients

Association between ventilatory settings and development of acute respiratory distress syndrome in mechanically ventilated patients due to brain injury

Manejo general en Cuidados Intensivos del paciente con hemorragia subaracnoidea espontánea

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