Acute lymphoblastic leukemia: Are Egyptian children adherent to maintenance therapy?

Khalek, Elhamy Rifky Abdel; Sherif, Laila M; Kamal, Naglaa Mohamed; Gharib, Amal F.; Shawky, Hanan

doi:10.4103/0973-1482.147698

Cited by 13 publications

(2 citation statements)

References 28 publications

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“…In addition, other drivers of non-adherence or false report of adherence (eg. sociodemographic status [ 22 ], parental beliefs about medicines (BMQ), Patient’s and/or parent’s primary reasons for skipping medication doses due to their busy schedules [ 43 ], RBC transfusions from a donor with high TPMT activity) were not assessed in this research. These issues can be addressed in future studies with inclusion of larger number of patients form different Arabic countries around Jordan.…”

Section: Discussionmentioning

confidence: 99%

Adherence to 6-Mercaptopurine in children and adolescents with Acute Lymphoblastic Leukemia

et al. 2017

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ObjectiveStudies on children with Acute Lymphoblastic Leukemia (ALL) reported non-adherence in 2–54% of cases. The primary objective of this study was to assess rates of adherence to 6-MP using two different methods in children and adolescents with ALL. Secondary aim was to identify factors that influence adherence to 6-MP in children with ALL.MethodsAll eligible children with ALL who are (≤ 19) years old and receive 6-MP therapy for at least 1 month were approached to participate in the study. A total of 52 children with ALL and their primary caregivers were recruited. Adherence measures included an objective method (measuring 6-MP metabolites in packed Red Blood Cells (RBCs)) and a subjective method (using parent and child self-report via the Medication Adherence Report Scale; MARS; Adherence was defined as 90% or greater).ResultsRates of adherence varied across the measurement methods. Packed RBCs sample analysis indicated forty-four patients (84.6%) to be adherent. Using the MARS questionnaires, a total of 49 children (94.2%) were classified as being adherent according to the parental MARS questionnaire scores, while all the 15 children (100%) who answered the MARS (child) questionnaire were classified as adherent. Overall adherence rate was 80.8% within the studied population.ConclusionMARS scale was shown to overestimate adherence compared to measurement of 6-MP metabolites in the blood. A combination of both methods led to increased detection of non-adherence to thiopurine in children with ALL.

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Section: Discussionmentioning

confidence: 99%

Adherence to 6-Mercaptopurine in children and adolescents with Acute Lymphoblastic Leukemia

et al. 2017

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“…Many of the barriers that exist in LMICs also exist in Egypt. The top three barriers to childhood cancer care in Egypt are delays in diagnosis leading to advanced-stage at presentation, deaths due to infections and treatment-related toxicities and non-adherence to therapy [ 16 , 37 ]. Around 50% of children with cancer in Egypt experience delays in diagnosis, with a median delay of around 37–49 days from the start of symptoms until initiation of treatment [ 38 , 39 ].…”

Section: Resultsmentioning

confidence: 99%

An overview of childhood cancer care and outcomes in Egypt: a narrative review

Soliman,

Bolous,

Heneghan

et al. 2024

ecancer Journal

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Childhood cancer is an urgent priority in Egypt, owing to a large number of children with cancer, the great need and demand for paediatric oncology services, limited resources/funds and inferior survival outcomes. Therefore, an overview of the status of childhood cancer care in Egypt and an evidence-based approach towards optimal utilisation of resources/funds to improve this care are needed. This paper summarises key evidence about childhood cancer care and outcomes in Egypt. We conducted a narrative literature review using a structured search strategy of the MEDLINE database through the PubMed interface. All relevant evidence was summarised under five main sub-topics: (1) burden of childhood cancer in Egypt; (2) treatment approaches; (3) health outcomes; (4) costs and cost-effectiveness of treatment; and (5) barriers and facilitators to optimal childhood cancer care. We found high estimates of disease burden of childhood cancer in Egypt. Furthermore, childhood cancer treatment in Egypt is based on either implementing intensity-regulated protocols or adopting international protocols with or without adaptations to local contexts, leading to varying standards of care among the different treating centres. Limited data about the survival outcomes, costs and cost-effectiveness of treatment exist, although high-quality data from retrospective cohort studies were published from a large paediatric oncology centre (Children’s Cancer Hospital Egypt–57357). As Egypt joins the WHO Global Initiative for Childhood Cancers as a focus country, it is prepared to move towards streamlining national efforts to implement a national childhood cancer plan to advance care, improve health outcomes and optimise resource use. Through these efforts, Egypt could become a beacon of hope and a role model to other low- and middle-income countries seeking to improve their childhood cancer care.

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Two decades of childhood cancer care in Cameroon: 2000–2020

Afungchwi

Kruger

Kouya

et al. 2021

Pediatric Blood & Cancer

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Background: Before the year 2000, there was no dedicated childhood cancer service in Cameroon. The aim of this study was to investigate the progress made with pediatric oncology care in Cameroon from 2000 to 2020.Method: A literature search was conducted for published articles on childhood cancer in Cameroon and relevant documents, and conference abstracts were reviewed. The articles were analyzed under the themes: awareness, diagnosis, epidemiology, treatment, outcome, advocacy, partnerships, traditional and complementary medicine, palliative care, and capacity building.Results: Low awareness on childhood cancer was addressed with education activities targeting the general population and health care professionals. Cancer diagnosis was achieved with cytology, histology, and simple imaging. Management for common and curable cancers was implemented with use of modified treatment regimens for lowand middle-income settings. Nutritional support was shown to mitigate the effects of malnutrition on treatment toxicity, and support was provided for transportation and accommodation. There was good collaboration between the pediatric oncology professionals nationally and twinning with international partners. Capacity building activities led to the availability of three pediatric oncologists and pediatric oncology-trained nurses. Advocacy nationally led to the support of the Ministry of Health with pediatric oncology-specific priority actions in the latest national cancer control plan. Conclusion:Childhood cancer should receive the necessary attention of health care policymakers in Cameroon. With continued commitment of government, nongovernmental organizations, charities, childhood cancer specialists, patient and parent groups, there should be an improved future for children with cancer in Cameroon.

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Acute lymphoblastic leukemia: Are Egyptian children adherent to maintenance therapy?

Cited by 13 publications

References 28 publications

Adherence to 6-Mercaptopurine in children and adolescents with Acute Lymphoblastic Leukemia

Adherence to 6-Mercaptopurine in children and adolescents with Acute Lymphoblastic Leukemia

An overview of childhood cancer care and outcomes in Egypt: a narrative review

Two decades of childhood cancer care in Cameroon: 2000–2020

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