Acute Lymphoblastic Leukemia in Adolescents and Young Adults

Ribera, Josep‐Marǐa; Oriol, Albert

doi:10.1016/j.hoc.2009.07.002

Cited by 75 publications

(46 citation statements)

References 39 publications

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“…[1] ALL involves a specific subtype of lymphocyte, the T- or B-cell. [2] However, being a lymphoid neoplasm, variations exist in the prevalence of subtypes of ALL, in relation to geographic, environmental, socio-economic, ethnic and racial factors.…”

Section: Introductionmentioning

confidence: 99%

Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India

Mukhopadhyay

Gangopadhyay

Dasgupta

et al. 2013

Indian Journal of Medical and Paediatric Oncology

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Objective:Research in Eastern India especially among children and adolescents for acute lymphoblastic leukemia (ALL) have not been well documented until recently when it was conducted at a cancer institute of tertiary care with primary objectives of examining and correlating different cell surface markers involved with respect to disease surveillance thereby highlighting it as a strong prognostic marker for future diagnosis and treatment.Materials and Methods:A total of 500 consecutively selected ALL patients were diagnosed and treated according to National Cancer Institute protocol (MCP 841) for a period of 24-88 months during this hospital-based study.Results:Of the total, 50.4% had a higher incidence of T-ALL and 47.6% had pro-B, B-cell precursor ALL. Disease free survival and event free survival were remarkably higher in B-ALL adolescent patients as compared to T-ALL, who had significantly lower overall survival ratio. Prevalence of T-ALL was also observed in relapse cases for adolescent patients.Conclusions:We conclude that there is an increased prevalence of T-ALL among adolescents in Eastern India. Immunophenotypic analysis might help in proper evaluation and prediction of treatment outcomes with an increased thrust on studying age-specific incident rates enabling well planned future treatments for improved and better outcome.

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Section: Introductionmentioning

confidence: 99%

Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India

Mukhopadhyay

Gangopadhyay

Dasgupta

et al. 2013

Indian Journal of Medical and Paediatric Oncology

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“…Adult regimens are typically less intense than their pediatric counterparts, because it is thought that adults do not tolerate drugs utilized in ALL treatment as well as children do. Adolescents with ALL have a better outcome when treated with pediatric protocols compared to adult protocols [1][2][3], and there are also suggestions of improved outcomes of adult patients with ALL treated with pediatric-inspired chemotherapy schedules [4]. Whether these improved outcomes are a result of higher doses of non-myelosuppressive drugs or whether they relate to other factors such as the experience of physicians or stricter adherence to scheduled treatments is unclear.…”

mentioning

confidence: 99%

Outcome of adults with acute lymphoblastic leukemia treated with a pediatric-inspired therapy: a single institution experience

Ruíz-Delgado

Macías-Gallardo

Lutz‐Presno

et al. 2010

Leukemia & Lymphoma

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“…the age range from 0 to 14 years. 6 Paraneoplastic syndromes are syndromes resulting from the damage caused to the organs or tissues that are remote from the site of malignant neoplasm or its metastasis. Neurological paraneoplastic syndromes are rare, affecting 0.01% of the patients with cancer.…”

Section: Case Reportmentioning

confidence: 99%