Acute Lymphoblastic Leukemia of Burkitt’s Type (L3 ALL) with 8;22 and 14; 18 Translocations and Absent Surface Immunoglobulins

Gluck, William Larry; Bigner, Sandra H.; Borowitz, Michael J.; Brenckman, Wayne D.

doi:10.1093/ajcp/85.5.636

Cited by 32 publications

(19 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The implication of band 8q24 is the rule, found in 20 of the 24 cases. The frequency of variant Burkitt's translocation t (8;22) 8,9,12,14 in this context is noteworthy 9 but this region could also be implicated in t(8;14), 6, 7, 9, 10, 11 in t(8;9)(q24;p13) 13,16 or, as in our patient 1, in complex translocation t(8;14;18)(q24;q32;q21). 15 As in our patient 2, molecular implication of c-MYC could not always be demonstrated, 10,13 especially in translocations not involving immunoglobulin genes.…”

Section: Discussionsupporting

confidence: 57%

“…Immunophenotype study in these cases always revealed the presence of B cell-associated markers as CD10 and CD19 but some cases with a morphologic aspect of ALL L3 lacked cytoplasmic and membranous immunoglobulins. 6,8,9,10,12 This particular feature underlined by Gluck et al 8 was also found by Thangavelu et al, 9 who suspected a correlation with the presence of a t(8;14) associated with the t(14;18). All our cases expressed surface immunoglobulin with kappa light chains and were CD10 positive, all features consistent with Burkitt's lymphoma/leukemia or diffuse large-cell lymphoma.…”

Section: Discussionmentioning

confidence: 76%

“…[6][7][8][9][10][11][12][13][14][15][16][17] Most patients presented with a rapid deterioration of physical conditions with fatigue, fever, night sweat and weight loss. Initial presentation associated massive bone marrow infiltration, nodal and extranodal involvement with frequent soft tissue or bone masses.…”

Section: Discussionmentioning

confidence: 99%

“…[6][7][8][9][10][11][12][13][14][15][16][17] Most of these cases exhibited a pre-B or B cell ALL phenotype, had chromosomal abnormalities involving band 8q24 and/or c-MYC rearrangement and had a very aggressive clinical course. We report five new cases of de novo leukemia/lymphoma with t(14;18) translocation.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

De novo acute B cell leukemia/lymphoma with t(14;18)

Stamatoullas¹,

Buchonnet

Leprêtre³

et al. 2000

Leukemia

View full text Add to dashboard Cite

The t(14;18)(q32;q21) translocation is the most common translocation in B cell malignancies being found in 80% of follicular lymphomas and about 20% of diffuse large B cell lymphomas. Only rare cases of de novo acute B cell lymphoblastic leukemia with t(14;18) have been described. We describe five cases of this entity which appears to have very homogeneous clinical, phenotypic and genotypic features. None of these patients had prior history of follicular lymphoma. The disease was characterized by acute clinical features with nodal and/or extranodal disease, massive bone marrow infiltration and rapid increase of circulating blast cells of mature B cell phenotype. All patients disclosed complex chromosomal and molecular abnormalities involving at least the BCL-2 and c-MYC genes. Furthermore, three patients had evidence of BCL-6 involvement and one patient had a p53 mutation. Despite intensive chemotherapy, including for two patients allogeneic bone marrow transplantation in first complete remission, all patients died within a few months. Neuro-meningeal relapse occurred in three of the five patients in spite of neuro-meningeal prophylaxis. De novo leukemia/lymphoma with t(14;18) is a rare entity with a very poor prognosis. Whether early bone marrow transplant could modify the natural history of the disease remains to be determined. An intensive neuro-meningeal prophylaxis appears to be mandatory in these patients. Leukemia (2000Leukemia ( ) 14, 1960Leukemia ( -1966

show abstract

Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

De novo acute B cell leukemia/lymphoma with t(14;18)

Stamatoullas¹,

Buchonnet

Leprêtre³

et al. 2000

Leukemia

View full text Add to dashboard Cite

show abstract

“…There have been 11 case reports of Burkitt-type leukemia (ALL-L3) in the literature with both the t(14;18) and variants of c-MYC (t(8;14) or t(8;22)). [13][14][15][16][17][18] By contrast, concurrent t(2;8) and t(14;18) is very rare and has been reported only once in a cell line created from a patient with chronic lymphocytic leukemia. 19 In this case, an immortalized cell line initially carried t(14;18) without t(2;8).…”

Section: Discussionmentioning

confidence: 99%

Lymphoid neoplasms associated with concurrent t(14;18) and 8q24/c-MYC translocation generally have a poor prognosis

et al. 2006

View full text Add to dashboard Cite

We identified 14 B-cell neoplasms with concurrent t(14;18) and chromosome 8q24 or c-MYC translocations shown by conventional cytogenetics or fluorescence in situ hybridization analysis. All cases assessed by conventional cytogenetics had a complex karyotype. There were 10 men and four women, with a median age of 55 years (range, 29-72). None of these patients had a history of follicular lymphoma. The biopsy specimens were obtained from bone marrow, lymph node, and extranodal sites. Morphologically, nine neoplasms had features of Burkitt or atypical Burkitt lymphoma/leukemia and three were diffuse large B-cell lymphoma with high-grade cytologic features. The remaining two cases were plasmablastic myeloma and low-grade B-cell lymphoma, respectively. All cases expressed BCL-2. The proliferation index assessed by using Ki-67 (MIB1) was 5% in the low-grade B-cell lymphoma, 80% in the plasmablastic myeloma, 90-95% in three cases of diffuse large B-cell lymphoma, and ranged from 90 to 499% in most Burkitt and atypical Burkitt neoplasms. The patient with low-grade B-cell lymphoma was treated with rituximab. All other patients received intensive combination chemotherapy. Two of these patients underwent bone marrow transplantation, and one patient received radiation therapy in addition to transplantation. The median follow-up period was 9 months (range, 3-81). In all, 10 patients died with a median survival of 9 months (range, 3-81). We conclude that most B-cell lymphomas with concurrent t(14;18) and 8q24/c-MYC translocations fall within the morphologic spectrum of diffuse large B-cell and Burkitt lymphoma. These neoplasms are high-grade and are associated with a poor prognosis. However, this combination of molecular abnormalities can also rarely occur in other neoplasms, such as the cases of low-grade B-cell lymphoma and plasmablastic myeloma in this study.

show abstract

Brief report: Acute lymphoblastic leukemia of Burkitt Type (L3 ALL) with t(8;14) lacking surface and cytoplasmic immunoglobulins

Kaplinsky

Rechavi

1998

Med. Pediatr. Oncol.

View full text Add to dashboard Cite

Acute Lymphoblastic Leukemia of Burkitt’s Type (L3 ALL) with 8;22 and 14; 18 Translocations and Absent Surface Immunoglobulins

Cited by 32 publications

References 0 publications

De novo acute B cell leukemia/lymphoma with t(14;18)

De novo acute B cell leukemia/lymphoma with t(14;18)

Lymphoid neoplasms associated with concurrent t(14;18) and 8q24/c-MYC translocation generally have a poor prognosis

Brief report: Acute lymphoblastic leukemia of Burkitt Type (L3 ALL) with t(8;14) lacking surface and cytoplasmic immunoglobulins

Contact Info

Product

Resources

About