Acute lymphoblastic leukemia to acute myeloid leukemia: an unusual case report of lineage switching

Pandit, Sudarshan; Wasekar, Nilesh; Badarkhe, Girish; Nagarkar, Raj; Nagarkar, Rajnish

doi:10.1016/j.htct.2020.06.007

Cited by 3 publications

(4 citation statements)

References 19 publications

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“…The pathogenesis for lineage switch in acute leukemia is currently unknown. But several hypotheses have been proposed [3,4,12]. Firstly, it is associated with clonal selection.…”

Section: Discussionmentioning

confidence: 99%

“…Because of the rarity of this lineage switch of AML to T-ALL, the prognosis of this phenomenon is still variable, but lineage switch in acute leukemia often lead to poor prognosis and resistance to therapy [3,4,15].…”

Section: Discussionmentioning

confidence: 99%

“…During or after chemotherapy, an uncommon event termed lineage switch is observed, but it is a rare event. The rate of conversion from acute lymphoblastic leukemia (ALL) to AML has been found to be 6-9%, but conversion from AML to ALL is extremely rare in children [3,4].…”

Section: Introductionmentioning

confidence: 99%

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Lineage Switch Subsequently Developed after Isolated Extramedullary Relapse in Children with Acute Myeloid Leukemia

Park,

Yang,

Hyun

et al. 2023

Clin Pediatr Hematol Oncol

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Isolated extramedullary relapse (EMR) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in acute myeloid leukemia (AML) is relatively rare and the clinical significance is still not well characterized, particularly in children. During or after chemotherapy, an uncommon event termed lineage switch, in which the lineage at onset of leukemia converts to another lineage at a later time, is observed in a subset of leukemia patients, but it is a rare event. We report a 10-year-old boy with isolated mediastinal EMR after allo-HSCT for AML who subsequently experienced BM relapse with the cell lineage switching from AML to T-cell acute lymphoblastic leukemia.

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“…The pathogenesis for lineage switch in acute leukemia is currently unknown. But several hypotheses have been proposed [3,4,12]. Firstly, it is associated with clonal selection.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Lineage Switch Subsequently Developed after Isolated Extramedullary Relapse in Children with Acute Myeloid Leukemia

Park,

Yang,

Hyun

et al. 2023

Clin Pediatr Hematol Oncol

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“…Leukemia ranks as the thirteenth most prevalent cancer globally. It is classified into four primary subtypes-acute lymphoid leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), and chronic myelogenous leukemia (CML)-based on the predominant cell type (lymphoid or myeloid) and the pace of disease progression (acute or chronic) [1]. Among these subtypes, ALL mainly affects children and stems from the uncontrolled proliferation of bone marrow hematopoietic precursor cells.…”

Section: Introductionmentioning

confidence: 99%

Telomerase Inhibition in the Treatment of Leukemia: A Comprehensive Review

Bartoszewska,

Molik,

Woźniak

et al. 2024

Antioxidants

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Leukemia, characterized by the uncontrolled proliferation and differentiation blockage of myeloid or lymphoid precursor cells, presents significant therapeutic challenges despite current treatment modalities like chemotherapy and stem cell transplantation. Pursuing novel therapeutic strategies that selectively target leukemic cells is critical for improving patient outcomes. Natural products offer a promising avenue for developing effective chemotherapy and preventive measures against leukemia, providing a rich source of biologically active compounds. Telomerase, a key enzyme involved in chromosome stabilization and mainly active in cancer cells, presents an attractive target for intervention. In this review article, we focus on the anti-leukemic potential of natural substances, emphasizing vitamins (such as A, D, and E) and polyphenols (including curcumin and indole-3-carbinol), which, in combination with telomerase inhibition, demonstrate reduced cytotoxicity compared to conventional chemotherapies. We discuss the role of human telomerase reverse transcriptase (hTERT), particularly its mRNA expression, as a potential therapeutic target, highlighting the promise of natural compounds in leukemia treatment and prevention.

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Immune escape of B-cell lymphoblastic leukemic cells through a lineage switch to acute myeloid leukemia

Bełdzińska-Gądek,

Zarzycka,

Pastuszak

et al. 2024

Leukemia & Lymphoma

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Acute lymphoblastic leukemia to acute myeloid leukemia: an unusual case report of lineage switching

Cited by 3 publications

References 19 publications

Lineage Switch Subsequently Developed after Isolated Extramedullary Relapse in Children with Acute Myeloid Leukemia

Lineage Switch Subsequently Developed after Isolated Extramedullary Relapse in Children with Acute Myeloid Leukemia

Telomerase Inhibition in the Treatment of Leukemia: A Comprehensive Review

Immune escape of B-cell lymphoblastic leukemic cells through a lineage switch to acute myeloid leukemia

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