Acute lymphocytic and myelomonocytic leukemia associated with low platelet counts and a 21q- marker chromosome

Abstract

A terminal deletion of the long arm of one chromosome 21 at band q21 was found in two patients with acute leukemia and a low platelet count: one case of acute myelomonocytic leukemia and one case of acute lymphocytic leukemia. The segment deleted from chromosome 21 could not be found translocated to any other chromosome of the complement. The results indicate that the 21q- marker chromosome may be due to a true deletion and that the marker is no specific for primary thrombocythemia or other myeloproliferative disorders associated with thrombocytosis.

del(18)(p11)

“…Acute Myeloid Leukemia (AML) Epidemiology del(18)(p11) is found in 9 cases ( 0.1% of all AML cases with an abnormal karyotype) (Alimena et al, 1981;Brodeur et al, 1983;GFCH, 1990;Lawler et al, 1990;Mohamed et al, 1993;Davey et al, 1995;Krauter et al, 1998;Babicka et al, 2007;Kasyan et al, 2010) -1 case with M1 French-American-British (FAB) phenotype, 2 cases with M2, 1 case with M3, 1 case with M4, 1 case with M6 and 3 with AML, NOS (one diagnosed as therapy related AML). The sex ratio is significantly unbalanced, near M:F=3.5:1.…”

Clustering of aberrations to specific chromosomes in human neoplasms

“…Some preliminary evidence exists, demonstrating that certain chromosome changes in tumors may be ascribed to the fact that the patients in their earlier history have been in contact with mutagenic/carcinogenic agents. In a retrospective study of patients with AML, striking differences in the chromosome picture of their malignant cells were noticed between patients who had been exposed occupationally to chemical solvents, insecticides and petroleum products, and those without any known such exposure (MITELMAN et al 1978(MITELMAN et al , 1979c(MITELMAN et al , 1981. It may be concluded from these observations that certain environmental factors may cause chromosome damage in man, just as in experiments with animals or plants.…”