Acute manganese exposure impairs glutamatergic function in a young mouse model of Alzheimer’s disease

Influence of subchronic exposure to manganese carried by female rats during pregnancy on the behavioral and cognitive abilities of their offspring at later stages of postnatal development

“…However, in the experimental work of Polish scientists, it was shown that in adult rats fed a diet with the addition of an increased content of Cu for two months, the concentration of AChE in the blood and brain in-PHYSIOLOGY creased (Cendrowska-Pinkosz, Krauze, Juśkiewicz, and Ognik, 2021). As mentioned earlier, Mn exposure increases the risk of developing neurogenerative diseases (Bakulski et al, 2020;Spitznagel et al, 2023). It is interesting to note that in clinical and post-mortem studies in blood samples of patients with Alzheimer's disease and in the brain, despite a decrease in the enzymatic activity of AChE, elevated levels of this protein were found against the background of an increase in BBB permeability (Fishman et al, 1986;Kalaria, 1999;García-Ayllón et al, 2010;Kuvacheva et al, 2013;Campanari et al, 2014Campanari et al, , 2016.…”

“…Many scientific works are focused on the study of the effects of brain Mn accumulation on dopamine, glutamate and g-aminobutyric acid neurotransmission, because Mn neurotoxicity is linked with disturbances in motor and stereotypes behaviors. It is well known that Mn in the brain tissue affects neurotransmitter transport and protein functioning causing alterations in neurotransmitter levels (Lin et al, 2020;Spitznagel et al, 2023). However, data on changes in cholinergic systems of the central nervous system following the exposure to manganese are considerably less extensive (Koroleva, 2023).…”

Advances in the application of manganese dioxide and its composites for theranostics

“…MRI can monitor behavior during Mn(II) take up and capture the high-intensity signal retrospectively, which provides a basis for detecting neuronal diseases. Mn(II) has unique physiological properties that make it an appealing nerve contrast agent, including the ability to monitor cell transport kinetics and neuronal projection anatomy in the brain, 109 progress of Alzheimer's disease, [110][111][112] emotion management, 113 Parkinson's disease, 114 etc. Remarkably, MnO 2 can be reduced to Mn(II) in vivo, which plays a crucial role in imaging neurodegenerative diseases.…”

Sodium para‐aminosalicylic acid attenuates combined manganese/iron‐induced cortical synaptic damage in rats

“…Acute Mn exposure has been shown to impair glutamatergic function in a young mouse model of Alzheimer's disease 11 . Postsynaptic density protein 95 (PSD95) is a skeleton protein on the postsynaptic membrane, encoded by the disks large homolog 4 (DLG4) gene, and involved in the synthesis of synapses 12 .…”

“…10 Acute Mn exposure has been shown to impair glutamatergic function in a young mouse model of Alzheimer's disease. 11 Postsynaptic density protein 95 (PSD95) is a skeleton protein on the postsynaptic membrane, encoded by the disks large homolog 4 (DLG4) gene, and involved in the synthesis of synapses. 12 α-amino-3-hydroxy-5-methyl-4-isoxazol-propionicacid-receptor (AMPAR) and N-methyl-D-aspartate receptor (NMDAR) are two major glutamate receptors that play important roles in optimal neurotransmission as well as in neurodegenerative diseases.…”