Acute measles infection triggering an episode of liver transplant rejection

Sternfeld, Thomas; Spöri-Byrtus, V.; Riediger, Carina; Langer, Rupert; Frieß, Helmut; Schmid, Roland M.; Schulte‐Frohlinde, E.

doi:10.1016/j.ijid.2009.06.013

Cited by 21 publications

(21 citation statements)

References 11 publications

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“…Infection with measles virus postliver transplant manifesting as clinical illness is rare among adults. Graft rejection was reported in one case of measles infection in a cadaveric liver transplant recipient . On the contrary, our patient presented with resolving hepatitis.…”

Section: Discussioncontrasting

confidence: 52%

Measles hepatitis in a vaccinated liver transplant recipient: case report and review of literature

Mohiuddin

Almaslamani

Hashim

et al. 2017

Clinical Case Reports

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Section: Discussioncontrasting

confidence: 52%

Measles hepatitis in a vaccinated liver transplant recipient: case report and review of literature

Mohiuddin

Almaslamani

Hashim

et al. 2017

Clinical Case Reports

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“…We reported one case of mild varicella disease followed by severe acute rejection. The relationship between VZV disease and rejection is not certain, but it is conceivable that acute immune stimulation due to viral infection may have precipitated the rejection .…”

Section: Discussionmentioning

confidence: 99%

“…Severe symptoms, such as organ rejection or even death, have been reported due to vaccine‐preventable diseases in solid organ transplant recipients . Intestinal transplantation (Tx) carries one of the highest risk of rejection in solid organ transplantation; hence, patients are given high doses of immunosuppressive drugs exposing them to the highest risk of infection.…”

mentioning

confidence: 99%

Vaccinations, response, and controls before and after intestinal transplantation in children

Demir

Frange

Lacaille

2016

Pediatric Transplantation

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Vaccination is an effective strategy to decrease infections in transplant recipients. Children after intestinal transplantation carry a high risk of infection due to increased immunosuppression. In a series of 22 children after intestinal transplantation, we studied the vaccination schedules and the antibodies against vaccine-preventable diseases before transplantation, and at one and five yr after transplantation. We reviewed whether the vaccination schedules were complete, and we analysed the factors that may influence serological immunity and the incidence of disease in patients with deficient immunity. All patients completed the recommended vaccination schedules for DTaP-IPV and HBV. After transplantation, the negative antibodies against vaccine-preventable diseases were mostly related to an antirejection therapy: for DTaP-IPV: four of four patients with no antibody had been treated for rejection, for HBV: two of five, HAV: three of four, MMR: three of seven, and VZV: three of four. A post-transplantation varicella infection was followed by acute rejection, with probability for a relationship between both events. We observed 50% of varicella cases in unvaccinated children, highlighting the importance of pretransplant vaccination. Waning immunogenicity mediated by antibodies against vaccine-preventable disease after transplantation indicated a need for boosters. The recommendations should be regularly enforced, as the reliance on routine immunizations schedules is not adequate in immunocompromised patients.

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“…38 The infection has also been linked to the presentation of acute rejection. 39 The diagnosis of choice is based on the determination of specific IgM antibodies to the virus or the seroconversion of IgG. The presence of the viral genome can be detected using RT-PCR in throat swabs, urine and peripheral blood.…”

Section: Measles Virusmentioning

confidence: 99%