Acute melioid community-acquired pneumonia

Kung, Chia-Te; Li, Chao-Jui; Hung, Shin-Chiang; Ko, Sheung‐Fat; Chen, Min-Chi; Lee, Chen‐Hsiang; Liu, Jien-Wei

doi:10.1016/j.ijid.2011.04.015

Cited by 8 publications

(10 citation statements)

References 20 publications

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“…The top 24 global EM articles for 2011 are listed in Table 3 2–25 . The complete database of all 206 global EM articles for 2011, as well as full summaries and critical analyses of the top 24 global EM of articles of 2011, can be found online as Data Supplements S1 and S2 (available as supporting information in the online version of this paper).…”

Section: Resultsmentioning

confidence: 99%

“…They note that the presence or absence of plasma leakage remains an important factor in directing treatment for patients with Dengue fever. Kung et al 18 analyzed a series of cases of acute myeloid community‐acquired pneumonia in Taiwan. The following factors were predictive of myeloid‐type pneumonia: presentation during the rainy season, poor glycemic control, and shock on arrival.…”

Section: Discussionmentioning

confidence: 99%

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Global Emergency Medicine: A Review of the Literature From 2011

Schroeder

Jacquet²,

Becker³

et al. 2012

Academic Emergency Medicine

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Objectives: The Global Emergency Medicine Literature Review (GEMLR) conducts an annual search of published and unpublished articles relevant to global emergency medicine (EM) to identify, review, and disseminate the most important research in this field to a wide audience of academics and practitioners.Methods: This year, 7,924 articles written in seven languages were identified by our search. These articles were divided up among 20 reviewers for initial screening based on their relevance to the field of global EM. An additional two reviewers searched the grey literature. A total of 206 articles were deemed appropriate by at least one reviewer and approved by their editor for formal scoring of their overall quality and importance.Results: Of the 206 articles that met our predetermined inclusion criteria, 24 articles received scores of 17 or higher and were selected for formal summary and critique. Interrater reliability for our scoring system was good with an interclass correlation coefficient of 0.628 (95% confidence interval = 0.51 to 0.72).Conclusions: Compared to previous reviews, there was a significant increase in the number of articles that were devoted to emergency care in resource-limited settings, with fewer articles related to disaster and humanitarian response. The majority of articles that met our selection criteria were reviews that examined the efficacy of particular treatment regimens for diseases that are primarily seen in low-and middle-income countries.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Global Emergency Medicine: A Review of the Literature From 2011

Schroeder

Jacquet²,

Becker³

et al. 2012

Academic Emergency Medicine

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show abstract

“…Our previous matched care-control study comparing patients with melioidosis pneumonia and those with nonmelioid CAP showed that visiting the ED during the rainy season, poor control of glucose levels, and arriving in the ED in shock were independent risk factors for patients with CAP caused by B pseudomallei. 16 Currie and Jacups 17 also indicated that heavy rainfall in the 14 days before admission was an independent risk factor for pneumonia, septic shock, and death in patients with melioidosis. It is postulated that heavy rainfall with strong winds brings buried B pseudomallei isolates to the soil surface; thereafter, they are more likely to be inhaled at high concentrations causing pneumonic melioidosis; this may result in the increased severity associated with septic shock and early mortality.…”

Section: Discussionmentioning

confidence: 97%

“…21 However, we found that the early mortality rate of our patients with acute melioidosis pneumonia was 56%, which is much higher than that observed for both patients with CAP in the ED (2.5%) 22 and patients with nonmelioid CAP (18.3%) in our previous study. 16 The current recommended antimicrobial agents and dosages for CAP are not active against B pseudomallei in vitro. 2 A specific guideline for CAP that is caused by B pseudomallei is needed in addition to a locally adapted guideline for CAP treatment in an endemic area.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of patients with melioidosis treated in an emergency department

Liu

Huang

et al. 2012

Journal of Acute Medicine

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“…In some cohorts, inhospital mortality approaches 60%. 103 Unfortunately, early mortality (<48 hours) can also be high (above 40%), 103 hence clinical suspicion and use of adjunctive nonculture based tests are key to ensuring timely therapeutic treatment.…”

Section: Pulmonary Melioidosismentioning

confidence: 99%

Melioidosis: A Neglected Cause of Community-Acquired Pneumonia

Virk

Mukhopadhyay

Wiersinga

2020

Semin Respir Crit Care Med

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AbstractMelioidosis, caused by the facultative intracellular gram-negative pathogen Burkholderia pseudomallei, is an emerging cause of community-acquired pneumonia across the tropics. The majority of patients present with pneumonia with or without sepsis, but localized and asymptomatic infection is also well recognized. Recent modeling and epidemiological studies have demonstrated the widespread presence of B. pseudomallei in otherwise unrecognized regions with a predicted mortality of 90,000 deaths worldwide. Innovative environmental studies are also uncovering how hydrodynamic, pedology, fauna, and weather events influence geographic distribution and incidence of melioidosis cases. Of concern is the changes associated with global warming, which will be conducive to B. pseudomallei in combination with the global diabetes pandemic. In fact, over 80% of patient developing melioidosis have underlying comorbidities. For this great mimicker, culture remains the mainstay of diagnosis and despite availability of other assays, challenges still remain in reducing time to diagnosis and avoiding misdiagnosis. With institution of timely antimicrobials such as ceftazidime and supportive intensive care, overall mortality can be reduced to 10%, although this can still be as high as 50% in poorly resourced areas. Promise is on the horizon with the first human vaccine trials being planned for 2021. Meanwhile new multiomics techniques are giving us a better understanding of the role of virulence and host–pathogen interactions on patient outcomes.

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Acute melioid community-acquired pneumonia

Cited by 8 publications

References 20 publications

Global Emergency Medicine: A Review of the Literature From 2011

Global Emergency Medicine: A Review of the Literature From 2011

Clinical characteristics of patients with melioidosis treated in an emergency department

Melioidosis: A Neglected Cause of Community-Acquired Pneumonia

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