Acute Methamphetamine-Induced Hepatic and Pancreatic Ischemia

Merchant, Krupa; Schammel, Christine; Fulcher, James W.

doi:10.1097/paf.0000000000000486

Cited by 8 publications

(5 citation statements)

References 14 publications

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“…Patients developing IP have been reported in cases with clinically significant AP and have shown convincingly that this is one of the known causes of AP 5–17. The only case series previously describing IP consisted of 11 patients from a tertiary referral center in Germany 5.…”

Section: Discussionmentioning

confidence: 99%

“…Patients developing IP have been reported in cases with clinically significant AP and have shown convincingly that this is one of the known causes of AP. [5][6][7][8][9][10][11][12][13][14][15][16][17] The only case series previously describing IP consisted of 11 patients from a tertiary referral center in Germany. 5 As the German study was from a tertiary referral center it is very unlikely that it was population based whereas the current study was population based, with calculated incidence per 100,000 inhabitants annually which might explain some of the differences observed.…”

Section: Incidencementioning

confidence: 99%

“…Ischemic pancreatitis (IP) is a poorly defined clinical condition and there is no consensus on diagnostic criteria. Most of the literature on IP is based on case reports with a large variety of causes of IP 3–17. The largest study published to date is a study of patients with IP from a surgical department in Germany with 11 patients with IP of different underlying conditions 5.…”

mentioning

confidence: 99%

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Ischemic Pancreatitis Is an Important Cause of Acute Pancreatitis in the Intensive Care Unit

Baldursdottir

Andresson²,

Jonsdottir³

et al. 2021

Journal of Clinical Gastroenterology

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Background: Ischemic pancreatitis (IP) has mainly been described in case reports. The aims of the study were to assess the frequency, clinical characteristics and outcomes in patients with IP among patients hospitalized in the intensive care unit (ICU) for acute pancreatitis (AP).Methods: All patients with first time AP between 2011 and 2018 in the ICU of Landspitali Hospital, Iceland were retrospectively included. IP as an etiology required a clinical setting of circulatory shock, arterial hypotension, hypovolemia and/or arterial hypoxemia [PaO 2 of 60 mm Hg (8.0 kPa), or less] before the diagnosis of AP without prior history of abdominal pain to this episode. Other causes of AP were ruled out. IP patients were compared with patients with AP of other etiologies, also hospitalized in the ICU.Results: Overall 67 patients with AP were identified (median age 60 y, 37% females), 31% idiopathic, 24% alcoholic, 22% IP, 15% biliary, and 8% other causes. Overall, 15 (22%) fulfilled the predetermined criteria for IP, 9 males (64%), median age 62 years (interquartile range: 46 to 65). IP was preceded mainly by systemic shock (73%). Other causes included dehydration, hypoxia, or vessel occlusion to the pancreas. Necrosis of the pancreas was rare with one patient requiring pancreatic necrosectomy. Inpatient mortality was higher among patients with IP than in other patients with AP (33% vs. 14%, P = 0.12).Conclusions: IP was found in a significant proportion of AP patients hospitalized in the ICU. The main causes of IP were systemic shock and hypoxia. IP was associated with ∼30% mortality.

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Section: Discussionmentioning

confidence: 99%

Section: Incidencementioning

confidence: 99%

mentioning

confidence: 99%

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Ischemic Pancreatitis Is an Important Cause of Acute Pancreatitis in the Intensive Care Unit

Baldursdottir

Andresson²,

Jonsdottir³

et al. 2021

Journal of Clinical Gastroenterology

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“…MA overdose symptoms include dilated pupils, tachycardia, hypertension, chest pain, psychosis, seizures, hallucinations, hyperthermia, hyperventilation, and biphasic changes in arterial blood pressure. It can also lead to rhabdomyolysis, coma, acute coronary syndrome (ACS), and cardiopulmonary arrest 3,7,8 . There is no specific antidote or treatment for MA overdose.…”

Section: Introductionmentioning

confidence: 99%

Acute poisoning due to massive leaking of methamphetamine in a methamphetamine body packer: A case report

Motevalli

Hosseinzadeh

Barary

et al. 2022

Preprint

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“…According to the United Nations Office on Drugs and Crime (UNODC), MA is one of the most dangerous drugs due to its central nervous excitatory effect, highly addictive, and numerous related disorders [2][3][4]. MA causes toxicity such as liver, brain neurological, cardiovascular, immune system injury, physical, and mental problems (violence, anxiety, and paranoia) [5][6][7][8][9][10][11]. Thus, accurate identifi-cation and quantification of MA in the forensic samples is particularly important for investigations and fair trials of drug crimes [12].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Methamphetamine and Its Isomer N-Isopropylbenzylamine in Forensic Samples by Using a Modified LC-ESI-MS/MS Method

Yangxu

Xiao

et al. 2021

Journal of Nanomaterials

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Accurate identification and quantification of methamphetamine (MA) and its related substances are essential for the investigation and fair trial of drug offenses. In this study, a modified LC-ESI-MS/MS method for the simultaneous determination of MA and its isomer N-isopropylbenzylamine (N-IBA) in forensic samples was developed and validated. Optimum chromatographic separation of the target analytes was achieved on an Agilent Poroshell 120 SB-C18 column ( 4.6 × 100 mm, 2.7 μm) at 40°C with isocratic elution at the flow rate of 0.40 mL/min. The mobile phase was acetonitrile and 20 mM ammonium acetate solution containing 0.1% formic acid (80 : 20, v / v ). Positive ESI-MS/MS detection was performed in multiple reaction monitoring (MRM) mode to identify and quantify the target analytes. Method validation showed excellent linearity in the range of 0.51 ng/mL~51 ng/mL for MA and N-IBA. The low limit of detection (LLOD) and low limit of quantification (LLOQ) reached 0.1 ng/mL and 0.3 ng/mL for both analytes. The method showed a satisfactory accuracy with an inter- and intraday-relative error (RE) <20%, and a precision of inter- and intraday relative standard deviation (RSD) less than 15%. The validated method was successfully applied in real forensic samples and resulted in the detection of MA and N-IBA in 8 suspected samples in drug cases that only deemed MA positive using our previous routine screening procedure, which avoided the misidentification of N-IBA as MA.

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Acute Methamphetamine-Induced Hepatic and Pancreatic Ischemia

Cited by 8 publications

References 14 publications

Ischemic Pancreatitis Is an Important Cause of Acute Pancreatitis in the Intensive Care Unit

Ischemic Pancreatitis Is an Important Cause of Acute Pancreatitis in the Intensive Care Unit

Acute poisoning due to massive leaking of methamphetamine in a methamphetamine body packer: A case report

Simultaneous Determination of Methamphetamine and Its Isomer N-Isopropylbenzylamine in Forensic Samples by Using a Modified LC-ESI-MS/MS Method

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