Acute metronidazole-induced neurotoxicity: an update on MRI findings

Patel, Lakir; Batchala, P.; Almardawi, Ranyah; Morales, Robert E.; Raghavan, Prashant

doi:10.1016/j.crad.2019.11.002

Cited by 24 publications

(24 citation statements)

References 16 publications

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“…Due to its low biodegradability and high solubility in water, MNZ can easily be present in high concentrations in aquatic ecosystems [9,10]. The high MNZ concentration, alongside its carcinogenic, mutagenic, and cytotoxic properties, may cause severe diseases such as encephalopathies [11,12]. It has been shown that even in treated wastewater MNZ removal is not complete, showing the inefficiency of conventional wastewater treatment methods [13,14].…”

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confidence: 99%

Reusable Ag@TiO2-Based Photocatalytic Nanocomposite Membranes for Solar Degradation of Contaminants of Emerging Concern

et al. 2021

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Two significant limitations of using TiO2 nanoparticles for water treatment applications are reduced photocatalytic activity under visible radiation and difficulty recovering the particles after use. In this study, round-shaped Ag@TiO2 nanocomposites with a ≈21 nm diameter and a bandgap energy of 2.8 eV were synthesised by a deposition-precipitation method. These nanocomposites were immobilised into a porous poly (vinylidene fluoride-hexafluoropropylene) (PVDF-HFP) matrix and well-distributed within the pores. The photocatalytic activity of Ag@TiO2/PVDF-HFP against metronidazole (MNZ) under solar radiation was evaluated. Further, an adaptive neuro-fuzzy inference system (ANFIS) was applied to predict the effect of four independent variables, including initial pollutant concentration, pH, light irradiation intensity, and reaction time, on the photocatalytic performance of the composite membrane on MNZ degradation. The 10% Ag@TiO2/PVDF-HFP composite membrane showed a maximum removal efficiency of 100% after 5 h under solar radiation. After three use cycles, this efficiency remained practically constant, demonstrating the membranes’ reusability and suitability for water remediation applications.

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Section: Introductionmentioning

confidence: 99%

Reusable Ag@TiO2-Based Photocatalytic Nanocomposite Membranes for Solar Degradation of Contaminants of Emerging Concern

et al. 2021

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“…Symmetric, hyperintense lesions of the dentate nuclei are commonly present, with lesions of the callosal splenium and dorsal pons of the same signal characteristics being the next most common abnormalities. 2,4 5 Discontinuing metronidazole usually results in improvement Most patients experience complete symptom resolution upon cessation of metronidazole, and complete or near-complete radiologic resolution occurs in about 75% of cases. 2,4 The time course varies, but the symptoms of most patients resolve within 2 weeks.…”

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confidence: 99%

“…2,4 5 Discontinuing metronidazole usually results in improvement Most patients experience complete symptom resolution upon cessation of metronidazole, and complete or near-complete radiologic resolution occurs in about 75% of cases. 2,4 The time course varies, but the symptoms of most patients resolve within 2 weeks. 4 Practice | Five things to know about ...…”

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Metronidazole-induced neurotoxicity

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Daneman

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et al. 2021

CMAJ

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“…Les signes radiologiques typiques s'observent le plus souvent à l'IRM pondérée en T 2 , en séquence FLAIR (fluid-attenuated inversion recovery). Les anomalies souvent présentes sont des lésions symétriques hyperintenses au niveau des noyaux dentelés, avec parfois des lésions au niveau du splénium du corps calleux et de la partie dorsale du pont de Varole émettant les mêmes types de signaux caractéristiques 2,4 .…”

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Neurotoxicité du métronidazole

Quickfall

Daneman

Dmytriw

et al. 2021

CMAJ

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La neurotoxicité du métronidazole est sous-estiméeHabituellement prescrit pour des infections dues à des bactéries anaérobies et à des protozoaires, le métronidazole peut dans de rares cas causer des effets indésirables qui affectent le système nerveux central dont le mécanisme précis reste à élucider. Dans une étude cas -témoins, l'incidence des complications neurologiques a été de 0,25 %, mais il s'agit probablement d'une sous-estimation 1 .2 La neurotoxicité du métronidazole peut se manifester par divers syndromes cliniques Les caractéristiques fréquentes impliquant le système nerveux central incluent l'ataxie, la dysarthrie et l'altération de l'état mental, mais des manifestations plus rares comme des convulsions, l'encéphalopathie et la dysfonction cérébelleuse ont aussi été décrites 2 . La neuropathie périphérique prend la forme d'une diminution de la sensibilité, d'engourdissements et de douleur neuropathique. Environ le tiers des patients qui présentent des anomalies du système nerveux central manifesteront aussi des signes de neuropathie périphérique 2 .

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Acute metronidazole-induced neurotoxicity: an update on MRI findings

Cited by 24 publications

References 16 publications

Reusable Ag@TiO2-Based Photocatalytic Nanocomposite Membranes for Solar Degradation of Contaminants of Emerging Concern

Reusable Ag@TiO2-Based Photocatalytic Nanocomposite Membranes for Solar Degradation of Contaminants of Emerging Concern

Metronidazole-induced neurotoxicity

Neurotoxicité du métronidazole

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