Acute micro-outbreak of Chagas disease in the southeastern Amazon: a report of five cases

Brito, Andreza Karoline Souza Barros de; Sousa, Débora Raysa Teixeira de; Silva, Edson Fidelis da; Ruiz, Helton Jardys da Silva; Arcanjo, Ana Ruth Lima; Ortiz, Jessica Vanina; Brito, Sabrina Silva de; Jesus, Denison Vital de; Lima, Jorge Rubens Coelho de; Couceiro, Kátia do Nascimento; Silva, Mônica Regina Hosannah da Silva e; Barbosa-Ferreira, João Marcos; Guerra, Maria das Graças Vale Barbosa

doi:10.1590/0037-8682-0687-2021

Cited by 6 publications

(10 citation statements)

References 13 publications

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“…TcV gi|40737786 Tc Mncl2 palm fruits, especially açaí, represent a serious problem for the population's health, due to its capacity to affect a multitude of people simultaneously [8,[20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

“…The transmission of T. cruzi through food has been proven in different experimental models [18] and in humans [8, 19]. In the Amazon, events associated with the consumption of palm fruits, especially açaí, represent a serious problem for the population's health, due to its capacity to affect a multitude of people simultaneously [8, 20–23].…”

Section: Discussionmentioning

confidence: 99%

“…Facial and lower limb oedema was observed in patients of all age groups from 8 of the 10 outbreaks that occurred. Although these symptoms are observed in low frequency in cases of ACD by oral transmission, they have also been reported both in the Amazon region [21–23], other regions in Brazil and Latin America [5, 25].…”

Section: Discussionmentioning

confidence: 99%

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Acute Chagas disease associated with ingestion of contaminated food in Brazilian western Amazon

de Sousa,

de Oliveira Guerra,

Ortiz

et al. 2023

Tropical Med Int Health

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Objective To describe clinical, epidemiological and management information on cases of acute Chagas disease (ACD) by oral transmission in the state of Amazonas in western Amazon. Methods Manual and electronic medical records of patients diagnosed with ACD at the Fundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT‐HVD) were included. Results There were 147 cases of acute CD registered from 10 outbreaks that occurred in the state of Amazonas between 2004 and 2022. The transmission pathway was through oral route, with probable contaminated palm fruit juice (açaí and/or papatuá), and involved people from the same family, friends or neighbours. Of 147 identified cases, 87 (59%) were males; cases were aged 10 months to 82 years. The most common symptom was the febrile syndrome (123/147; 91.8%); cardiac alterations were present in 33/100 (33%), (2/147; 1.4%) had severe ACD with meningoencephalitis, and 12 (8.2%) were asymptomatic. Most cases were diagnosed through thick blood smear (132/147; 89.8%), a few (14/147; 9.5%) were diagnosed by serology and (1/147; 0.7%) by polymerase chain reaction (PCR) and blood culture. In all these outbreaks, 74.1% of the patients were analysed by PCR, and Trypanosoma cruzi TcIV was detected in all of them. No deaths were recorded. The incidence of these foci coincided with the fruit harvest period in the state of Amazonas. Conclusion The occurrence of ACD outbreaks in the Amazon affected individuals of both sexes, young adults, living in rural and peri‐urban areas and related to the consumption of regional foods. Early diagnosis is an important factor in surveillance. There was a low frequency of cardiac alterations. Continuous follow‐up of most patients was not carried out due to difficulty in getting to specialised centres; therefore, little is known about post‐treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Acute Chagas disease associated with ingestion of contaminated food in Brazilian western Amazon

de Sousa,

de Oliveira Guerra,

Ortiz

et al. 2023

Tropical Med Int Health

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“…Com relação a distribuição dos casos notificados e confirmados de DCA no país, a região Nordeste é caracterizada como sendo a segunda região mais predominante, sendo a região Norte com maior prevalência de casos (Brito et al, 2022). A raça parda obteve 100% frequência absoluta, em concordância aos estudos em regiões do Nordeste, Norte e nacional (Andrade et al, 2020;Alencar et al, 2020).…”

Section: Ano Do 1º Sintoma (S)unclassified

Doença de Chagas aguda: Um recorte epidemiológico entre 2012-2021 do estado do Piauí no Brasil

Silva,

Barroso,

Fonseca

et al. 2024

RSD

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Objetivou conhecer o perfil clínico-epidemiológico dos casos confirmados de Doença de Chagas Aguda (DCA) no estado do Piauí, no período de 2012 a 2021. Foi realizado um estudo epidemiológico, descritivo e retrospectivo, de abordagem quantitativa no período de 2012 a 2021 de casos confirmados de DCA no estado do Piauí. Foram notificados quatro casos de DCA, com elevação no número de notificações em 2021, tendo o município de Oeiras o maior número de casos notificados confirmados (75%), com maior incidência de provável infecção através do modo vetorial com critério de confirmação laboratorial e boa evolução clínica. A principal faixa etária acometida foi entre 65-69 anos (50%), raça parda foi a única notificada e sem variação entre os sexos. É fundamental conhecer dados epidemiológicos concisos do estado do Piauí para melhoria da assistência médica, prevenção e controle da Doença de Chagas. Assim, o estudo permitiu conhecer inicialmente o perfil socioepidemiológico do estado com relação a DCA, porém orienta ações para melhoria do diagnóstico clínico da DCA e correto preenchimento da Ficha de Notificação Compulsória para que pesquisas futuras deem subsídio para novas implementações em saúde pública do estado.

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“…8 In the last 15 years, systematic occurrence of acute cases of CD, outbreaks related either to oral transmission by the ingestion of contaminated foods, mainly in the Amazon region, or to vectorial transmission due to accidental exposure to the wild cycle of the etiologic agent. 7,9 CD has become an urban condition in the 80's, with the rural-urban migration, with a high number of patients currently living in the periphery of large cities. 10,11 Considering the high uncertainty of the Brazilian numbers, a giant step has been taken with the compulsory notification of the cases since 2020 (decree number 1061 of May 18, 2020); however, unfortunately, very little progress has been seen since then, due to the COVID-19 pandemic, and the weakening of programs for the care of CD patients.…”

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confidence: 99%

Advances in Clinical Practice, Diagnosis and Treatment of Chronic Chagas’ Heart Disease

Alves¹,

Silva²,

Barbosa³

et al. 2023

ABC Heart Fail Cardiomyop

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Chagas disease has become globalized as a result of the migratory process of infected patients to non-endemic areas. With the considerable number of individuals affected by the disease, detection and treatment of its chronic manifestations is a relevant and necessary issue. Growing attention has been paid to chronic Chagas cardiomyopathy (CCC), which includes heart failure, malignant arrhythmias, conduction disturbances and thromboembolic events. Many pharmacological and nonpharmacological treatments for CCC are still extrapolations of existing evidence on the treatment of other clinical conditions, highlighting the need of including this group of patients in future studies. In this review, we will discuss the most recent data from the literature and clinical practice on the diagnosis and treatment of CCC. IntrodutionChagas disease (CD) is a neglected tropical disease that affects socially vulnerable individuals that experience stigma, discrimination and high morbidity and mortality, especially those with the cardiac form of the disease. 1,2 Changes in the epidemiological landscape of CD have been described worldwide.With the migratory phenomenon, CD has become globalized. Especially coming from the Latin America, CD

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Acute micro-outbreak of Chagas disease in the southeastern Amazon: a report of five cases

Cited by 6 publications

References 13 publications

Acute Chagas disease associated with ingestion of contaminated food in Brazilian western Amazon

Acute Chagas disease associated with ingestion of contaminated food in Brazilian western Amazon

Doença de Chagas aguda: Um recorte epidemiológico entre 2012-2021 do estado do Piauí no Brasil

Advances in Clinical Practice, Diagnosis and Treatment of Chronic Chagas’ Heart Disease

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