2009
DOI: 10.1038/cmi.2009.15
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Acute Morphine Administration Reduces Cell-Mediated Immunity and Induces Reactivation of Latent Herpes Simplex Virus Type 1 in BALB/c Mice

Abstract: Acute morphine administration is known to alter the course of herpes simplex virus infection. In this study, the effect of acute morphine administration on the reactivation of latent herpes was investigated in a mouse model. Because of the important role of cytolytic T lymphocyte (CTL) activity in the inhibition of herpes simplex virus type 1 (HSV-1) reactivation, the effect of acute morphine administration on CTL responses was also evaluated.

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Cited by 32 publications
(16 citation statements)
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“…1823 Opioids are associated with immunosuppression and opioid-induced endocrinopathy (sexual dysfunction, depression, decreased energy). 24–30 Opioids are implicated in opioid-induced hyperalgesia or increased pain sensitivity despite increasing doses of opioids. This hyperalgesia has been demonstrated with exposure to both short- and long-term opioids.…”
Section: Risks Associated With Opioid Use After Surgerymentioning
confidence: 99%
“…1823 Opioids are associated with immunosuppression and opioid-induced endocrinopathy (sexual dysfunction, depression, decreased energy). 24–30 Opioids are implicated in opioid-induced hyperalgesia or increased pain sensitivity despite increasing doses of opioids. This hyperalgesia has been demonstrated with exposure to both short- and long-term opioids.…”
Section: Risks Associated With Opioid Use After Surgerymentioning
confidence: 99%
“…The adverse effects of prescription opioids are well documented including the presence of tolerance and physical dependence [8][9][10][11][12][13][14][15][16][17][18][19][20]. Opioids are also implicated in opioidinduced hyperalgesia or increased pain sensitivity despite increasing doses of opioids [21][22][23].…”
mentioning
confidence: 99%
“…Morphine acts primarily as a μ-opioid receptor agonist with lesser affinity for the δ-opioid and κ-opioid receptors [12]. These G-protein coupled receptors are expressed in multiple regions, including the central nervous system [13,14], the gastrointestinal tract [15], and immune system [16], and can induce effects ranging from analgesia and addiction to peripheral immunosuppression [17–20]. …”
Section: Introductionmentioning
confidence: 99%