Acute motor axonal neuropathy associated with anal carcinoma: Paraneoplastic neurological syndrome or coincidence?

López, J.; Amezcua, Salvador; Pascual, Jordi; Algara, Manuel

doi:10.1016/j.rpor.2010.12.003

Cited by 7 publications

(2 citation statements)

References 17 publications

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“…Presentation with concurrent neurological symptoms as a direct consequence of malignancy is additionally uncommon in anal SCC. The only report of such an association we found during our literature review was of a case of tetraplegia possibly secondary to paraneoplastic syndrome, where a diagnosis of anal SCC was reached months later 16…”

Section: Discussionmentioning

confidence: 91%

Unilateral leg weakness and pain secondary to metastatic anal squamous cell carcinoma

2019

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A 58-year-old man presented to colorectal clinic with intermittent rectal bleeding, weight loss, also pain and weakness affecting his lower back and right leg. On inspection, there were perianal warts (condyloma acuminata), with an additional palpable anal lesion on digital rectal examination, confirmed by colonoscopy. Subsequent imaging revealed a large right psoas abscess, and an associated paravertebral soft tissue component invading the right lumbosacral plexus and nerve roots at L4, L5 and S1. Biopsy of the paravertebral mass revealed metastatic squamous cell carcinoma. Given his symptomatology, and also as biopsy of the perianal warts revealed high-grade squamous intraepithelial lesion/grade III anal intraepithelial neoplasia on histology with infection by human papillomavirus type 6, the primary was presumed to be anal. This was a case of sciatic pain which proved to be diagnostically challenging on initial presentation to primary care. This mode of presentation and pattern of metastasis are uncommon in anal cancer.

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Section: Discussionmentioning

confidence: 91%

Unilateral leg weakness and pain secondary to metastatic anal squamous cell carcinoma

2019

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“…Symptoms may include lumps or bumps located near the anus, anal bleeding or bleeding during bowel movements, anal discharge, pain in or around the anus, itchy sensation around or inside the anus, change in bowel habits, such as constipation, diarrhea and thinning of the stools or para-neoplastic syndrome. 4 Due to the low frequency of distant metastases at the time of diagnosis, anal cancer is considered mainly a loco-regional disease, making concomitant radio-chemotherapy an ideal organ and function sparing treatment which has been the standard of care for decades, with excellent results even in locally advanced tumors. Since the 1980s, many attempts have been made to improve loco-regional control and reduce toxicity, evaluating the role of mitomycin and investigating the role of IMRT.…”

Section: Introductionmentioning

confidence: 99%

Radio-chemotherapy in anal cancer: Institutional experience at a large radiation oncology center in Chile

Russo

Ovalle

2014

Reports of Practical Oncology & Radiotherapy

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Pain as a First Manifestation of Paraneoplastic Neuropathies: A Systematic Review and Meta-Analysis

et al. 2017

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IntroductionParaneoplastic neurological syndromes (PNS) consist of a heterogeneous group of neurological disorders triggered by cancer. The aim of this systematic review is to estimate the reported prevalence of pain in patients with paraneoplastic peripheral neuropathy (PPN).MethodsA systematic computer-based literature search was conducted on PubMed database.ResultsOur search strategy resulted in the identification of 126 articles. After the eligibility assessment, 45 papers met the inclusion criteria. Full clinical and neurophysiological data were further extracted and involved 92 patients with PPN (54.5% males, mean age 60.0 ± 12.2 years). The commonest first manifestation of PPN is sensory loss (67.4%), followed by pain (41.3%), weakness (22.8%), and sensory ataxia (20.7%). In 13.0% of the cases, pain was the sole first manifestation of the PPN. During the course of the PPN, 57.6% of the patients may experience pain secondary to the neuropathy.ConclusionsPain is very prevalent within PPN. Pain specialists should be aware of this. Detailed history-taking, full clinical examination, and requesting nerve conduction studies might lead to an earlier diagnosis of an underlying malignancy.

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Acute motor axonal neuropathy associated with anal carcinoma: Paraneoplastic neurological syndrome or coincidence?

Abstract: The presence of anti-GM1 IgG antibodies and the clinical improvement of the motor state after concurrent chemoradiotherapy lead us to believe there is an association between anal carcinoma and this severe impairment.

Cited by 7 publications

References 17 publications

Unilateral leg weakness and pain secondary to metastatic anal squamous cell carcinoma

Unilateral leg weakness and pain secondary to metastatic anal squamous cell carcinoma

Radio-chemotherapy in anal cancer: Institutional experience at a large radiation oncology center in Chile

Pain as a First Manifestation of Paraneoplastic Neuropathies: A Systematic Review and Meta-Analysis

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