Acute myelitis by human herpes virus 7 in an HIV-infected patient

Escobar-Villalba, Alfonso; Cantero, Susana; Torre, Paula Pérez; Galán, Juan Carlos; Rodríguez-Domínguez, Mario; Laguillo, Enric Monreal; Ulloa, Pedro Luis Martínez; Catevilla, Javier Buisán; Corral, Íñigo

doi:10.1016/j.jcv.2016.02.001

Cited by 14 publications

(12 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The case presented here contributes to the delineation of the approach to a patient profile with a similar clinical presentation and evolution to those presented in the literature [6–11]. All relevant information about these cases is presented in Table 1.…”

Section: Discussionmentioning

confidence: 76%

Encephalitis associated with human herpesvirus-7 infection in an immunocompetent adult

Parra

Alcala

Amorós

et al. 2017

Virol J

View full text Add to dashboard Cite

BackgroundPrimary Human herpesvirus-7 (HHV-7) infection usually occurs during childhood and causes several clinical manifestations: mainly exanthem subitum (roseola infantum), followed by a lifelong latent state with possible reactivation in case of immunodeficiency. Nevertheless, some considerably different approaches exist regarding the natural history of HHV-7 and the possible consequences of HHV-7 infection in immunocompetent adults. In particular, little is known about its pathogenic role in central nervous system (CNS) disease in nonimmunosuppressed adults. Specifically, in case of encephalitis, it is important to distinguish between infectious encephalitis and postinfectious encephalomyelitis for the management of patientsCase presentationWe describe here a case of encephalitis associated to human herpesvirus-7 with associated polymyeloradiculopathy in an immunocompetent patient which may contribute to the delineation of the approach to a patient profile with a similar clinical presentation and evolution to those presented in the literature.ConclusionsThis case may alert clinicians to consider this specific etiology in the differential diagnosis of encephalopathy in patients with suspected infectious encephalitis who do not respond to acyclovir or in patients who develop acute polymyeloradiculopathy, considering that HHV-7 may be a pathological factor and that a timely diagnosis is crucial for the early administration of specific treatment.Electronic supplementary materialThe online version of this article (doi:10.1186/s12985-017-0764-y) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 76%

Encephalitis associated with human herpesvirus-7 infection in an immunocompetent adult

Parra

Alcala

Amorós

et al. 2017

Virol J

View full text Add to dashboard Cite

show abstract

“…This herpes virus was also recently described as a causative agent of severe human encephalitis in a HIV-1 infected patient [98]. In the same line of this report, in 2016 the first evidence of a correlation between HHV-7 reactivation and acute myelitis was published [99]. Regarding the polyomaviruses, JCV is known to cause progressive multifocal leukoencephalopathy (PML) in HIV-1 infected individuals [100], resulting from oligodendrocyte lytic infection.…”

Section: The Role Of Co-infectionsmentioning

confidence: 97%

The Role of HIV Infection in Neurologic Injury

et al. 2017

View full text Add to dashboard Cite

The central nervous system (CNS) is a very challenging HIV-1 sanctuary, in which HIV-1 replication is established early on during acute infection and can persist despite potent antiretroviral treatments. HIV-1 infected macrophages play a pivotal role acting as vehicles for HIV-1 to spread into the brain, and can be the major contributor of an early compartmentalization. HIV-1 infection in CNS may lead to a broad spectrum of neurological syndromes, such as dementia, mild neurocognitive disorders, and asymptomatic impairment. These clinical manifestations are caused by the release of neurotoxins from infected cells (mainly macrophages), and also by several HIV-1 proteins, able to activate cell-signaling involved in the control of cellular survival and apoptosis. This review is aimed at highlighting the virological aspects associated with the onset of neurocognitive disorders and at addressing the novel therapeutic approaches to stop HIV-1 replication in this critical sanctuary.

show abstract

“…Given that the patient had anti‐HHV‐7 IgG titers at the initial stage of the disease, we propose that reactivation of HHV‐7 caused central nervous system manifestations of acute myelitis. Acute myelitis associated with HHV‐7 infection has been rarely reported in immune‐compromised hosts . Thus, this report suggests that even healthy non‐immunocompromised children can develop acute myelitis associated with reactivation of HHV‐7.…”

Section: Discussionmentioning

confidence: 70%