Acute myelogenous leukaemia in a mare

Nc, Ringger; Edens, Lucy M.; Bain, Perry; Re, Raskin; R, Larock

doi:10.1111/j.1751-0813.1997.tb15702.x

Cited by 29 publications

(22 citation statements)

References 6 publications

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“…In other horses with myelogenous leukemia, hyperglobulinemia usually is characterized by increases in ␣ 2 and ␤ fractions, but increases in ␥-globulin concentrations also have been observed. 3,7,8,11,39 These increases in ␣-, ␤-, and ␥-globulin fractions are nonspecific and consistent with chronic inflammation.…”

Section: Jvim 15 209 Mp 151mentioning

confidence: 92%

Immunophenotypic Classification of Leukemia in 3 Horses

McClure

Young

Fiste

et al. 2001

Veterinary Internal Medicne

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Section: Jvim 15 209 Mp 151mentioning

confidence: 92%

Immunophenotypic Classification of Leukemia in 3 Horses

McClure

Young

Fiste

et al. 2001

Veterinary Internal Medicne

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“…This type of leukemia has been diagnosed in horses aged between 2 and 11 years, and of different breeds, such as Standardbred trotters, Thoroughbreds, Quarter Horses, and Hassians [6, 10, 60, 66] (Table 1…”

Section: Equine Myeloproliferative Disordersmentioning

confidence: 99%

Hematopoietic Neoplasias in Horses: Myeloproliferative and Lymphoproliferative Disorders

Muñoz

Riber

Trigo

et al. 2009

JES

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Leukemia, i.e., the neoplasia of one or more cell lines of the bone marrow, although less common than in other species, it is also reported in horses. Leukemia can be classified according to the affected cells (myeloproliferative or lymphoproliferative disorders), evolution of clinical signs (acute or chronic) and the presence or lack of abnormal cells in peripheral blood (leukemic, subleukemic and aleukemic leukemia). The main myeloproliferative disorders in horses are malignant histiocytosis and myeloid leukemia, the latter being classified as monocytic and myelomonocytic, granulocytic, primary erythrocytosis or polycythemia vera and megakaryocytic leukemia. The most common lymphoproliferative disorders in horses are lymphoid leukemia, plasma cell or multiple myeloma and lymphoma. Lymphoma is the most common hematopoietic neoplasia in horses and usually involves lymphoid organs, without leukemia, although bone marrow may be affected after metastasis. Lymphoma could be classified according to the organs involved and four main clinical categories have been established: generalized-multicentric, alimentary-gastrointestinal, mediastinal-thymic-thoracic and cutaneous. The clinical signs, hematological and clinical pathological findings, results of bone marrow aspirates, involvement of other organs, prognosis and treatment, if applicable, are presented for each type of neoplasia. This paper aims to provide a guide for equine practitioners when approaching to clinical cases with suspicion of hematopoietic neoplasia.

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“…A single corticosteroid treatment, dexamethasone, was used for intestinal T cell lymphoma in three horses, and two showed clinical improvement (Gerber et al, 2002). Others have used only corticosteroids in horses with little success although some horses seem to improve briefly as well as did the mare described here (Bernard et al, 1988;Ringger et al, 1997). Surprising results were obtained by Rendle et al (2007); in their study three horses with LL were given corticosteroid treatment and survived from 11 months to 5 years.…”

Section: Discussionmentioning

confidence: 79%

“…Differentiation between primary lymphoid leukemia and the leukemic phase of a lymphoma can be achieved with the finding of solid tumors in lymphoma cases. Most cases of lymphoid leukemia are secondary to a lymphoma and only a few cases of primary LL have been reported in horses (Roberts, 1977;Ringger et al, 1997;Clark et al, 1999). No solid tumor was found during clinical and gross examination in this case.…”

Section: Discussionmentioning

confidence: 79%

See 1 more Smart Citation

Acute B-lymphoid leukemia in a mare: a case report

Bezděková¹,

Faldyna²,

Zapletal³

et al. 2009

Vet. Med. - Czech

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An 8-year-old Friesen mare was admitted to the Equine Clinic, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic with ventral edema and weight loss which had proceeded over the course of a few weeks. Clinical examination revealed poor body condition, depression, weakness, pale mucous membranes, enlarged mandibular lymph nodes and ventral edema. Thoracic percussion revealed fluid level reaching the shoulder on both sides. CBC revealed a severe disproportion of red and white cells. The horse was anemic and there was leucocytosis with the majority being blast cells (leucocyte concentration was 450.4 × 10 9 /l) which included mitotic figures. The serum chemistry profile revealed hypoalbuminemia and increased alkaline phosphatase bone isoenzyme (BALP was 784.3 µkat/l). Based on the number of precursors in the peripheral blood acute leukemia was diagnosed. The peripheral blood was examined by flow cytometry and cytochemistry. The final diagnosis was determined as acute B cell lymphoid leukemia. The mare was treated with corticosteroids. On the second day of treatment the white blood cell count and alkaline phosphatase level decreased. The improvement continued until the fifth day, when the mare's status deteriorated and the horse was euthanized. Gross examination was carried out but no neoplastic mass was discovered. Final differentiation between primary and secondary lymphoid leukemia was not possible in this case.

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Acute myelogenous leukaemia in a mare

Cited by 29 publications

References 6 publications

Immunophenotypic Classification of Leukemia in 3 Horses

Immunophenotypic Classification of Leukemia in 3 Horses

Hematopoietic Neoplasias in Horses: Myeloproliferative and Lymphoproliferative Disorders

Acute B-lymphoid leukemia in a mare: a case report

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