Acute myelogenous leukemia: Morphologic classification and response to therapy

Foon, Kenneth A.; Naiem, Faramarez; Yale, Coralee; Gale, Robert Peter

doi:10.1016/0145-2126(79)90015-8

Cited by 48 publications

(17 citation statements)

References 12 publications

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“…33 With modern chemotherapy regimens, the initial response rate is 60-65% for all patients, with a median duration of remission of 18-24 months and 20% remaining disease free for up to 12 years. 9,39 The complete response rate for identically treated patients older than 60 is < 50%. 7,31 Older patients may have a worse prognosis due to decreased ability to withstand the toxicity of therapy or altered biologic characteristics of leukemia.…”

Section: Discussionmentioning

confidence: 99%

Acute Myelogenous Leukemia Relapsing as Granulocytic Sarcoma of the Cervix

Delaflor-Weiss

Zauber²,

Kintiroglou³

et al. 1999

Acta Cytologica

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Section: Discussionmentioning

confidence: 99%

Acute Myelogenous Leukemia Relapsing as Granulocytic Sarcoma of the Cervix

Delaflor-Weiss

Zauber²,

Kintiroglou³

et al. 1999

Acta Cytologica

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“…[3][4][5][6][7][8][18][19][20][21] No significant differences in response rates and survival have been observed by some 3,18,19 ; others found that patients with myelomonocytic leukemia had a longer survival than those with pure myeloid leukemia, 5,20 while others found that they had a decreased response rate. 4 Patients with monocytic leukemia are reported to have a decreased complete remission rate, 7 early relapses and failure to achieve a second complete remission, 21 and an apparent decreased survival.…”

Section: Discussionmentioning

confidence: 99%

“…It differs significantly from all reported series from Western centers. [3][4][5][6][7] The response of ANLL to various induction chemotherapy regimens combining cytarabine, daunorubicin, and thioguanine, in the doses and schedules used in our patients, has been reviewed in the literature with the conclusions that no one way is significantly better, nor could be recommended more than the others [14][15][16][17] ; this has allowed us to group our patients together. No attempt was made to compare them because of small numbers.…”

Section: Discussionmentioning

confidence: 99%

Adult Acute Nonlymphocytic Leukemia in Saudi Arabia: Experience at King Khalid University Hospital in Riyadh

et al. 1989

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Twenty-two adult patients with acute nonlymphocytic leukemia (ANLL) were analyzed. There were 15 males (68%) and 7 females (32%). Their median age was 42 years. Thirty-six percent had acute myelomonocytic leukemia (M4), and 46% had acute monocytic leukemia (M5), according to the French-American-British classification. Of 17 patients who received intensive combination chemotherapy, 47% achieved complete remission. Of the subgroup of 14 new and previously untreated patients, the complete remission rate was 57%. The rest of the patients died of septic complications. We report an increased ratio of M4 and M5 in ANLL in Saudi Arabia and an increased rate of severe septic and fungal complications.

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“…Although the French-American-British (FAB) classification, based on the morphologic and cytochemical feature of the leukemic cell, is used worldwide for acute leukemia, it has been known to produce low agreement among analyzers and has not provided sufficient information regarding the prognosis of the leukemia [1, 2, 3, 4]. After the 1980s, leukemic cell immunophenotype and cytogenetic abnormalities were reported to have some prognostic significance [5, 6, 7, 8, 9, 10].…”

Section: Introductionmentioning

confidence: 99%

Expression of Functional Markers in Acute Nonlymphoblastic Leukemia

Han¹,

Kahng²,

Kim³

et al. 2000

Acta Haematol

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Multidrug resistance parameters, tissue infiltration parameters, receptors for colony-stimulating factors (CSFr) and cell cycle parameters were analyzed using flow cytometry in 145, 109 initial and 36 relapsed or refractory, acute nonlymphoblastic leukemia (ANLL) patients to find out clinically more reliable functional parameters. Lung resistance-associated protein (LRP) was most frequently expressed in ANLL (44.1%) followed by P-glycoprotein (PGP) (35.9%) and multidrug resistance-associated protein (MRP) (8.3%). LRP and PGP were expressed more frequently in relapsed or refractory ANLL than initial ANLL cases. Complete remission rate after standard chemotherapy falls in PGP-positive cases (p = 0.001). CD44-positive ANLL cases relapsed more frequently. The organ tropism is different depending on the infiltration parameters, vascular cell adhesion molecule to splenomegaly, matrix metalloprotease-2 to hepatomegaly and to extramedullary infiltration other than spleen, liver or lymph node. The percentage of the granulocyte-macrophage-CSFr expression was high in M4 and M5, and granulocyte-CSFr-positive ANLL showed less extramedullary infiltration (p = 0.007) and more PGP expression. Ki-67 was expressed significantly less in refractory ANLL than initial ANLL and DNA topisomerase IIα was expressed significantly more in the surviving patients group. In conclusion, analysis of these new functional parameters could help to predict and overcome the clinical behavior of each ANLL at the time of diagnosis.

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Acute myelogenous leukemia: Morphologic classification and response to therapy

Cited by 48 publications

References 12 publications

Acute Myelogenous Leukemia Relapsing as Granulocytic Sarcoma of the Cervix

Acute Myelogenous Leukemia Relapsing as Granulocytic Sarcoma of the Cervix

Adult Acute Nonlymphocytic Leukemia in Saudi Arabia: Experience at King Khalid University Hospital in Riyadh

Expression of Functional Markers in Acute Nonlymphoblastic Leukemia

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