Acute myelogenous leukemia presenting as atypical mastoiditis with facial paralysis

Todd, N. Wendell; Bowman, Carol A.

doi:10.1016/s0165-5876(84)80041-5

Cited by 54 publications

(39 citation statements)

References 5 publications

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“…A post-operative CT scan of the temporal bone which shows the relapse of granuloblastic sarcoma in the wide residual middle ear cavity (2 months after surgical intervention). most common presenting symptom in temporal bone involvement is an aching post-auricular swelling, associated with a generally conductive hearing loss, otalgia and tinnitus, until the onset of an acute otomastoiditis, caused by bacterial superinfection [5,16,28,36]. Eustachian tube obstruction or infiltration, secondary to leukemic involvement of the nasopharynx, suffusion and/or effusion of the middle ear mucosa, can lead to acute otomastoiditis [31].…”

Section: Discussionmentioning

confidence: 99%

“…Eustachian tube obstruction or infiltration, secondary to leukemic involvement of the nasopharynx, suffusion and/or effusion of the middle ear mucosa, can lead to acute otomastoiditis [31]. Massive bony erosion, deafness and vertigo may develop at a later stage due to progression of the lesion, if untreated [8,9,11,30,36].…”

Section: Discussionmentioning

confidence: 99%

“…The surgical management of chloroma is restricted to obtaining a tissue diagnosis, draining infection and reducing neoplastic infiltration before chemotherapy and/or radiotherapy. If the tumour does not seem to originate from the facial nerve, its decompression would not seem appropriate [36]. If the leukemic involvement is localized in the petrous bone, local low-dose radiotherapy and systemic chemotherapy are the treatments of choice.…”

Section: Discussionmentioning

confidence: 99%

“…This hematological disease can affect the external, middle and inner ear, as far as the petrous apex [2, 5,19,24,29,36,38,39]. Such involvement depends on: (1) neoplastic infiltration, (2) infections and (3) hemor-rhage.…”

Section: Introductionmentioning

confidence: 99%

“…Such involvement depends on: (1) neoplastic infiltration, (2) infections and (3) hemor-rhage. Leukemia in the ear can cause bleeding hemorrhages of the external ear and tympanic membrane, skin lesions of the external auditory canal, red or thick tympanic membrane, hemorrhagic or serous acute otitis media with effusion or suffusion of the mucosa of the middle ear, conductive or sensorineural hearing loss, acute otomastoiditis with facial or acoustic cranial nerve paralysis [10,11,16,18,19,20,24,36,38,39].…”

Section: Introductionmentioning

confidence: 99%

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Facial nerve paralysis in acute otomastoiditis as presenting symptom of FAB M2, T8;21 leukemic relapse. Case report and review of the literature

Almadori

Ninno

Cadoni

et al. 1996

International Journal of Pediatric Otorhinolaryngology

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Granulocytic sarcoma (chloroma) is a rare solid, extramedullary tumour composed of immature granulocytes, occurring during granulocytic leukemia. Leukemic involvement of the temporal bone is not uncommon and may present in a variety of ways. Symptomatic facial nerve paralysis is one of these. The authors report a case of facial nerve paralysis as the presenting symptom of leukemic relapse in a 16-year-old white male, affected by acute myelogenous leukemia FAB M2, karyotype 46xy, T8;21.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Facial nerve paralysis in acute otomastoiditis as presenting symptom of FAB M2, T8;21 leukemic relapse. Case report and review of the literature

Almadori

Ninno

Cadoni

et al. 1996

International Journal of Pediatric Otorhinolaryngology

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Acute myeloblastic leukemia presenting as apparent acute otitis media

et al. 1988

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Three cases of acute myeloblastic leukemia of FAB-M2 type revealed by an isolated otitis media are reported. This mean of revelation is valuable for early diagnosis and treatment of the disease. A karyotype was performed in two cases and showed an 8;21 translocation. As far as we know, these are the first acute myeloblastic leukemia cases with otitis media reported in which an 8;21 translocation was detected.

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Presenting features and imaging in childhood acute myeloid leukemia with central nervous system involvement

Ranta

Palomäki

Levinsen

et al. 2017

Pediatric Blood & Cancer

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Central nervous system (CNS) involvement in childhood acute myeloid leukemia (AML) can manifest as leukemic cells in the cerebrospinal fluid, a solid CNS tumor, or as neurological symptoms.We evaluated the presenting symptoms and neuroimaging findings in 33 of 34 children with AML and CNS involvement at diagnosis in the period 2000-2012 in Sweden, Finland, and Denmark.Imaging was performed in 22 patients, of whom 16 had CNS-related symptoms. Seven patients, including all but two with facial palsy, had mastoid cell opacification, considered an incidental finding. The frequent involvement of the mastoid bone with facial palsy warrants evaluation in larger series.

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Acute myelogenous leukemia presenting as atypical mastoiditis with facial paralysis

Cited by 54 publications

References 5 publications

Facial nerve paralysis in acute otomastoiditis as presenting symptom of FAB M2, T8;21 leukemic relapse. Case report and review of the literature

Facial nerve paralysis in acute otomastoiditis as presenting symptom of FAB M2, T8;21 leukemic relapse. Case report and review of the literature

Acute myeloblastic leukemia presenting as apparent acute otitis media

Presenting features and imaging in childhood acute myeloid leukemia with central nervous system involvement

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